Squamous cell carcinoma arising in mature cystic teratoma with sigmoid invasion

Srivastava, Pooja; Dawson, Leelavathi; Mandal, Ashish Kumar

doi:10.4103/0973-1482.148692

Cited by 9 publications

(15 citation statements)

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“…The patients are usually asymptomatic; although symptoms like abdominal pain and abdomino‐pelvic mass may be seen, similar to this case. It may be discovered accidentally during gynecologic examination due to mass effect . Acute intestinal obstruction may occur when there is adherence of a part of small bowel to the mass .…”

Section: Discussionmentioning

confidence: 99%

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Mature cystic teratoma of ovary with squamous cell carcinoma arising from it

Maharjan

2019

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

“…It may be discovered accidentally during gynecologic examination due to mass effect. 19 Acute intestinal obstruction may occur when there is adherence of a part of small bowel to the mass. 20 Advance cases may develop constitutional symptoms such as cachexia and weight loss.…”

Section: Discussionmentioning

confidence: 99%

Mature cystic teratoma of ovary with squamous cell carcinoma arising from it

Maharjan

2019

Clinical Case Reports

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“…Due to the different components of a teratoma, there can be various malignant transformations, such as squamous cell carcinomas (75%-80%), adenocarcinomas (7%), sarcomas (7%), basal cell carcinomas, sebaceous gland carcinomas, malignant melanomas, small cell lung cancers, transitional cell carcinomas, clear cell carcinomas, and gliomas [1,[3][4][5][6] . The patholog-ical diagnosis confirmed that this case was a teratoma accompanied by the malignant transformation of a sebaceous gland carcinoma, which is very rare.…”

Section: Discussionmentioning

confidence: 99%

“…Tumors show up as off-white or light yellow and brittle, and they are often accompanied by bleeding and necrosis. A malignant transformation often occurs in the inner papilla of the cyst wall, near the nodules, in the inhomogeneous enhanced portion or the thickening cyst wall [3,4,13] . Therefore, surgeons should carefully examine the cyst wall of the specimen.…”

Section: Yun-xiao Zhou Et Al 24mentioning

confidence: 99%

“…Surgeons should not blindly rely on the typical manifestations of mature ovarian teratomas, such as hair and teeth, which may lead to a misdiagnosis. Current studies have shown that the histological analysis of intraoperative frozen sections can identify teratomas with a malignant transformation, avoid secondary surgery to completely remove the tumor, and improve the life quality of these patients [3,4] . Currently, the therapeutic selections for teratomas with malignant transformations remain controversial.…”

Section: Yun-xiao Zhou Et Al 24mentioning

confidence: 99%

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Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Zhou

Jin

et al. 2018

Clin Surg Res Commun

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A mature ovarian teratoma is a common benign germ cell tumor of the ovary in women that rarely causes a malignant transformation. However, a malignant transformation can occur in the ectodermal, mesodermal, and endodermal tissues of the tumor. A squamous cell carcinoma is the most common and an adenocarcinoma is the second most common malignant tumor derived from a cystic teratoma. Due to the rarity of malignant transformations in mature teratomas and the lack of clinical data, the clinical pathological features, malignant transformation mechanism, therapeutic methods, and prognosis-relevant factors are unclear. Currently, there is no specific diagnostic method, and it is a difficult lesion to diagnose before performing surgery. In order to improve clinicians' understanding of a malignant-transformed mature teratoma and identification of malignant-transformed teratomas at early stages, we have reported a case of a mature teratoma with the malignant transformation of a sebaceous gland carcinoma in the Yiwu Central Hospital in Zhejiang, China on May 31, 2018. A review of the literature is also presented to summarize the clinical symptoms, pathogenesis, diagnosis, and treatment of malignant-transformed mature teratomas.

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Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Zhang

et al. 2019

BMC Cancer

134

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Background0.17–2% of mature cystic teratoma of the ovary (MCTO) undergo malignant transformation, of which 80% are squamous cell carcinoma (SCC) transformation in MCTO. We aim to investigate the clinical characteristics and treatment of SCC transformation in MCTOMethodsWe systematically searched PubMed database and individual patient data about SCC transformation in MCTO were extracted. The published cases were combined with 6 cases of SCC transformation in MCTO from Qilu Hospital, Shandong University.ResultsThe incidence of SCC transformation in MCTO was 0.3%. A total of 435 cases of SCC transformation in MCTO were enrolled in the analysis. The mean age of diagnosis was 53.5 (range 19–87) years old. The most common clinical manifestations were abdominal pain (47.3%) and abdominal mass (26.0%). StageI,II, III and IV accounted for 50.0, 18.8, 26.8 and 4.4% of all cases, respectively. Patients with stage I had significantly better prognosis than stage II, III and IV patients (P < 0.01). Hysterectomy can improve overall survival (P < 0.01). For patients younger than 45 years old with stageIA orIC, there was no difference in mortality between fertility-sparing and radical surgery (P = 1.00). Adjuvant chemotherapy can improve survival in patients with advanced stage (P = 0.02), and chemotherapy with platinum was related to better prognosis (P = 0.02).ConclusionSCC transformation in MCTO is a rare malignancy mainly occurs in older age. FIGO stage is an independent prognostic factor. Hysterectomy and platinum-based chemotherapy are associated with better survival. Fertility-sparing surgery is feasible for young patients with early stage.Electronic supplementary materialThe online version of this article (10.1186/s12885-019-5393-y) contains supplementary material, which is available to authorized users.

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Squamous cell carcinoma arising in mature cystic teratoma with sigmoid invasion

Cited by 9 publications

References 0 publications

Mature cystic teratoma of ovary with squamous cell carcinoma arising from it

Mature cystic teratoma of ovary with squamous cell carcinoma arising from it

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

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