Squamous cell carcinoma arising in a dermoid cyst of the ovary

Powell, John L.; Stinson, Jeffrey A; Connor, G. Patrick; Shiro, Brian C.; Mattison, Michael

doi:10.1016/s0090-8258(03)00135-5

Cited by 29 publications

(11 citation statements)

References 4 publications

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“…We mainly used the platinum based chemotherapy in our institution due to its known activity against epithelial ovarian cancer and squamous cell carcinoma of the cervix (Omura et al, 1985;McGuire et al, 1996;Piccart et al, 2000;Zenetta et al, 2000). There were several previous studies supporting combination chemotherapy with paclitaxel and carboplatin as active agents in malignant transformation arising from mature cystic teratoma and reported that most patients had an extended progression-free interval (Eltabbakh et al, 1998;Ohtani et al, 2000;Powell et al, 2003;Dos Santos et al, 2007;Yamagami et al, 2007;Arioz et al, 2008;Sakuma et al, 2010). From those literatures, we mostly used combination chemotherapy with paclitaxel and cisplatin/carboplatin in our patients and found overall response rate around 60%.…”

Section: Discussionmentioning

confidence: 98%

Characteristics and Treatment Outcomes of Patients with Malignant Transformation Arising from Mature Cystic Teratoma of the Ovary: Experience at a Single Institution

Oranratanaphan¹,

Khemapech²

2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 98%

Characteristics and Treatment Outcomes of Patients with Malignant Transformation Arising from Mature Cystic Teratoma of the Ovary: Experience at a Single Institution

Oranratanaphan¹,

Khemapech²

2013

Asian Pacific Journal of Cancer Prevention

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“…1,5,7 Squamous cell carcinoma make up almost 85% of the malign transformation cases in mature cystic teratoma. 1,2,7,8 Adenocarcinoma, carcinoid tumor, malign melanoma, sebaseous carcinoma, carcinosarcoma, small cell carcinoma, sarcoma (leiomyosarcoma, chondrosarcoma, osteosarcoma) have also been reported. [9][10][11][12][13][14][15][16] In this study incidence rates of the tumors are similar to the literature with the incidence rate of squamous cell carcinoma was found (33,3%).…”

Section: Discussionmentioning

confidence: 99%

Malign Transformation in the Mature Cystic Teratoma of the Ovary: Presentation of 9 Case Studies

Sayhan¹,

Ayaz²,

Keçeci³

et al. 2015

Turkiye Klinikleri J Gynecol Obst

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A AB BS S TTR RA AC CT T O Ob bj je ec ct ti iv ve e: : Mature cystic teratoma (MCT) is the most frequently observed ovarian germ cell tumor. It constitutes up to 10-20% of the ovarian tumors. The incidence rate of malign transformation in ovarian mature cystic teratoma is approximately 2%. Clinical presentation of malignant MCT depends on the extension and histological type of the secondary malignancy. Squamous cell carcinoma is the most common secondary tumor seen in malignantly-transformed MCT cases. The prognosis of patients with malignant transformation in teratoma is very poor and most patients die within 1 year. However, the prognosis is better if the tumor is limited to one ovary, with an intact capsule not adhered to adjacent structure and with a uniform thickness of the cyst wall. In this study, the incidence, histologic types, and prognosis of the malign transformed MCT were assessed. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Six hundred seventy-six cases were diagnosed as mature cystic teratoma of the ovary between January 2000 and December 2010 in our Pathology Laboratory, Tepecik Obstetrics and Gynecology Hospital. Malignant transformation was determined in 9 of these patients (1.48%) of whom operative data, histopathologic findings, and postoperative follow-up data were evaluated in light of the literature. R Re es su ul lt ts s: : Out of 676 mature cystic teratoma cases, malignant transformation was determined in nine of them (1.48%). Six out of nine patients were in the postmenopausal period while two were in perimenopausal period and one was premenopausal period. Median age was found to be 45.7 (34-71 years). The average diameter of the ovarian tumor was 9.5 (7-15) cm. The tumor settled on the left in five cases, whereas it settled on the right in four cases. Squamous cell carcinoma was found in three cases, mucinous cystadenocarcinoma was found in two cases, thyroid papillary carcinoma was found in two cases, carcinoid tumor was found in one case and signet ring cell carcinoma was found in one case. According to surgical FIGO staging, four cases were classified as stage IA, three cases were classified as stage IC, one case was classified as stage II B and one case was classified as stage II C. Average follow-up period was 71 months (5-126 months). C Co on nc cl lu us si io on n: : In cases preliminary diagnosed as mature cystic teratoma, malign transformation possibility should be considered especially in women in postmenopausal period and in those with large-size tumors. Frozen section examination plays an important role in identifying both the method of surgical treatment and the patient prognosis. K Ke ey y W Wo or rd ds s: : Ovarian neoplasms; teratoma; carcinoma; cell transformation, neoplastic Ö ÖZ ZE ET T A Am ma aç ç: : Matür kistik teratom (MKT) en sık görülen ovarian germ hücreli tümördür. Over tümörlerinin %10-20 kadarını oluşturur. Overin matür kistik teratomlarının malign transformasyon insidensi yaklaşık %2 civarındadır. Malign değişim gösteren MKT'nin klinikte ...

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“…Suspicious areas like a hemorrhagic, necrotic nodule or an abnormal thickening of a cyst wall should always be sampled in order to exclude a second malignancy like a squamous cell carcinoma [73] . Squamous cell carcinoma accounts for 75-85% of the malignant degeneration while adenocarcinoma has been reported to occur in 6.8% of cases [74,75] . Malignant transformation of a mature cystic teratoma of the ovary occurs in approximately 2% of all cases and is more likely when the age of the woman exceeds the age of 40 [76,77] .…”

Section: Fsd For Distinguishing Types Of Ovarian Neoplasmsmentioning

confidence: 99%

Intraoperative Consultation in Ovarian Pathology

Akrivos

Thomakos

Sotiropoulou

et al. 2010

Gynecol Obstet Invest

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Ovarian specimens are very commonly submitted for intraoperative consultation (frozen section diagnosis) in order to confirm the presence of malignancy, to give the surgeon all the information for the histologic type of the tumor and finally determine the extent of surgery. In most cases, intraoperative consultation regarding ovarian masses accurately determines the type of malignancy. The pathologist and the gynecologist must be aware of the applications, indications and limitations of frozen section. Despite its limitations, frozen section diagnosis represents a sensitive and specific technique that can play a very important role in the management of ovarian disease.

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Squamous cell carcinoma arising in a dermoid cyst of the ovary

Cited by 29 publications

References 4 publications

Characteristics and Treatment Outcomes of Patients with Malignant Transformation Arising from Mature Cystic Teratoma of the Ovary: Experience at a Single Institution

Characteristics and Treatment Outcomes of Patients with Malignant Transformation Arising from Mature Cystic Teratoma of the Ovary: Experience at a Single Institution

Malign Transformation in the Mature Cystic Teratoma of the Ovary: Presentation of 9 Case Studies

Intraoperative Consultation in Ovarian Pathology

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