Characteristics and Treatment Outcomes of Patients with Malignant Transformation Arising from Mature Cystic Teratoma of the Ovary: Experience at a Single Institution

Oranratanaphan, Shina; Khemapech, Nipon

doi:10.7314/apjcp.2013.14.8.4693

Cited by 23 publications

(9 citation statements)

References 40 publications

(37 reference statements)

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“…Large-scale clinical prospective study is not feasible because of the low incidence of SCC transformation in MCTO and the published cases are scattered, and the optimal treatment for SCC transformation in MCTO remains unclear [9]. Some doctors hold the idea that since SCC originates from epithelium so its treatment should follow principles that of epithelial ovarian cancer [10, 11], some believe that the treatment should refer to SCC of other sites [12], and some suggest that since the malignancy presents on the basis of MCTO, which is a kind of ovarian germ cell tumors, the treatment can refer to that of ovarian germ cell malignancy. However, the surgical principle and postoperative adjuvant therapy of epithelial ovarian cancer, ovarian germ cell tumors and squamous cell carcinoma are different [13].…”

Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Zhang

et al. 2019

BMC Cancer

134

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Background0.17–2% of mature cystic teratoma of the ovary (MCTO) undergo malignant transformation, of which 80% are squamous cell carcinoma (SCC) transformation in MCTO. We aim to investigate the clinical characteristics and treatment of SCC transformation in MCTOMethodsWe systematically searched PubMed database and individual patient data about SCC transformation in MCTO were extracted. The published cases were combined with 6 cases of SCC transformation in MCTO from Qilu Hospital, Shandong University.ResultsThe incidence of SCC transformation in MCTO was 0.3%. A total of 435 cases of SCC transformation in MCTO were enrolled in the analysis. The mean age of diagnosis was 53.5 (range 19–87) years old. The most common clinical manifestations were abdominal pain (47.3%) and abdominal mass (26.0%). StageI,II, III and IV accounted for 50.0, 18.8, 26.8 and 4.4% of all cases, respectively. Patients with stage I had significantly better prognosis than stage II, III and IV patients (P < 0.01). Hysterectomy can improve overall survival (P < 0.01). For patients younger than 45 years old with stageIA orIC, there was no difference in mortality between fertility-sparing and radical surgery (P = 1.00). Adjuvant chemotherapy can improve survival in patients with advanced stage (P = 0.02), and chemotherapy with platinum was related to better prognosis (P = 0.02).ConclusionSCC transformation in MCTO is a rare malignancy mainly occurs in older age. FIGO stage is an independent prognostic factor. Hysterectomy and platinum-based chemotherapy are associated with better survival. Fertility-sparing surgery is feasible for young patients with early stage.Electronic supplementary materialThe online version of this article (10.1186/s12885-019-5393-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Zhang

et al. 2019

BMC Cancer

134

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“…Compared to benign MCTs, the prognosis of MCTs with malignant transformation is poor, and the preoperative prediction and detection of these malignant MCTs are extremely difficult. [ 2 , 4 ] Moreover, the clinicopathologic characteristics, treatment, prognostic factors and the mechanism of malignant transformation are not yet well understood owing to the rarity of such tumors, especially in reproductive-age women. Therefore, we report a case of a young woman with the malignant transformation of a recurrent MCT and review the literature, with focus on the values and methods of early prediction or detection of the disease in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Rare case of squamous cell carcinoma arising in a recurrent ovarian mature cystic teratoma of a young woman

Feng

2018

Medicine

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Rationale:Malignant transformations of ovarian mature cystic teratomas (MCTs) occur rarely, especially in young women. Although it is extremely difficult to diagnose them, serum tumor marker level testing in combination with the use of imaging techniques may be useful in preoperative diagnosis.Patient concerns:We present the case of a 31-year-old Chinese woman with the malignant transformation of an ovarian MCT. The patient had a history of oophorocystectomy due to an MCT of the right ovary 6 years prior and a gemellary pregnancy owing to in vitro fertilization and embryo transfer. Her serum CA19-9 levels were persistently mildly elevated after the first surgery.Diagnoses:She was diagnosed with ovarian squamous carcinoma, arising from an MCT (International Federation of Gynecology and Obstetrics stage IA).Interventions:A right salpingo-oophorectomy and omentectomy were performed and the patient underwent chemotherapy.Outcomes:The patient was disease-free at the 6-month follow-up.Lessons:The malignant transformation of MCTs usually occurs in postmenopausal women with poor prognoses; it is very rarely observed in young women. Although the early detection and complete surgical resection of the tumor are crucial to survival, preoperative diagnosis of this malignancy is difficult. This case reiterates the fact that malignant transformation of MCTs can occur at any age. Rapid tumor growth along with persistently elevated tumor marker levels may be indicative of the malignant transformation of MCTs.

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“…One part of a mature teratoma can cause a malignant transformation. However, the malignant transformation rate is low, accounting for 1%-3% of all teratomas, and these are usually found in pre and postmenopausal women [1,2] . Here, we have described the case of a mature teratoma with a malignant transformation along with its clinicopathological features.…”

Section: Introductionmentioning

confidence: 99%

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Zhou

Jin

et al. 2018

Clin Surg Res Commun

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A mature ovarian teratoma is a common benign germ cell tumor of the ovary in women that rarely causes a malignant transformation. However, a malignant transformation can occur in the ectodermal, mesodermal, and endodermal tissues of the tumor. A squamous cell carcinoma is the most common and an adenocarcinoma is the second most common malignant tumor derived from a cystic teratoma. Due to the rarity of malignant transformations in mature teratomas and the lack of clinical data, the clinical pathological features, malignant transformation mechanism, therapeutic methods, and prognosis-relevant factors are unclear. Currently, there is no specific diagnostic method, and it is a difficult lesion to diagnose before performing surgery. In order to improve clinicians' understanding of a malignant-transformed mature teratoma and identification of malignant-transformed teratomas at early stages, we have reported a case of a mature teratoma with the malignant transformation of a sebaceous gland carcinoma in the Yiwu Central Hospital in Zhejiang, China on May 31, 2018. A review of the literature is also presented to summarize the clinical symptoms, pathogenesis, diagnosis, and treatment of malignant-transformed mature teratomas.

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Characteristics and Treatment Outcomes of Patients with Malignant Transformation Arising from Mature Cystic Teratoma of the Ovary: Experience at a Single Institution

Cited by 23 publications

References 40 publications

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Rare case of squamous cell carcinoma arising in a recurrent ovarian mature cystic teratoma of a young woman

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

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