Squamous cell carcinoma arising in chronic osteomyelitis

Abstract

Squamous cell carcinoma (SCC) is a rare but well-documented complication of chronic osteomyelitis. Between February 1991 and March 1999, 13 cases (12 men and one woman) of SCC arising in chronic osteomyelitis were diagnosed and treated in our clinic. Mean age was 56.5 (38-70) years. Twelve patients underwent amputation and one underwent limb salvage. Average follow-up was 56 (24-121) months. Among the 13 patients two died of the disease. Treatment of choice for these tumours has been amputation.Resume Carcinome cellulaire squameux est une complication d'ostéomyélite, peu fréquente, mais bien connue. Entre le février 91-mars 99, dans notre clinique, nous ont constate 13 malades (12 hommes et 1 femme) a qui nous ont vu la maladie développe a la base d'ostéomyélite chronique. L'age moyen était 56.5. (38-70) 12 malades ont subi une amputation et dans l'autre l'extrémité a été gardée. La surveillance a duré à peu près 56 (24-121) mois. Parmi ces 13 malades seulement deux sont morts. Pour ces tumeurs on peut dire que l'amputation est la méthode la plus efficace.

Chronic bacterial and parasitic infections and cancer: a review

“…The tumors that develop on chronic osteomyelitis are generally squamous cell carcinomas [14,[141][142][143][144][145][146][147][148][149][150][151][152].…”

Squamous Cell Carcinoma as a Late Complication of Chronic Osteomyelitis

“…Squamous cell carcinoma (SCC) is a rare but well documented complication of osteomyelitis. [1][2][3][4][5][6][7][8][9] The incidence of this rare complication has been estimated at 0.23 -1.6% of all cases of chronic Osteomyelitis. 5 The tumour develops after 4.5 to 50 years (average 30 years) of chronic infection with a discharging fistula.…”

“…Squamous cell carcinoma is a rare but well documented complication of osteomyelitis. [1][2][3][4][5][6][7][8][9] Prompt and adequate treatment of acute haematogenous osteomyelitis can prevent this complication arising from the same. With the advent of antibiotics, better health care delivery to the people and improving socio-economic conditions, the incidence of squamous cell carcinoma arising as a late complication of acute haematogenous osteomyelitis will become increasingly less.…”

Early diagnosis is vital in the management of squamous cell carcinomas associated with chronic non healing ulcers: a case series and review of the literature

“…A malignant clone may arise within an ulcer over time, possibly through chronic antigenic or non specific stimulation (1), as seen in Marjolin's ulcer — the development of a squamous cell carcinoma (SCC) from long‐standing, non healing ulcers or scars. In addition, SCCs could also develop from a wide variety of chronic conditions such as pressure ulcers (2), pilonidal sinus wounds (3) and osteomyelitis (4). However, the most common types of SCC arise de novo , from premalignant lesions such as Bowen's disease or from pre‐existing skin lesions such as actinic keratosis (5).…”