Squamous Cell and Basal Cell Carcinoma of the Skin in Relation to Radiation Therapy and Potential Modification of Risk by Sun Exposure

Karagas, Margaret R.; Nelson, Heather H.; Zens, Michael S.; Linet, Martha S.; Stukel, Thérèse A.; Spencer, Steve; Applebaum, Katie M.; Mott, Leila A.; Mabuchi, Kiyóhiko

doi:10.1097/ede.0b013e3181567ebe

Cited by 68 publications

(43 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A skin cancer case-control study among New Hampshire residents found that radiotherapy risk was statistically high in the subjects who had not experience sunburn and the risk in those who had experience sunburn did not increase, although the difference in the risks between those two groups was not significant (28). These two reports suggested that radiation effects were stronger on skin that was unlikely to be exposed to UV radiation.…”

Section: Figmentioning

confidence: 99%

Skin Cancer Incidence among Atomic Bomb Survivors from 1958 to 1996

Sugiyama

Misumi

Kishikawa³

et al. 2014

Radiation Research

Self Cite

View full text Add to dashboard Cite

The radiation risk of skin cancer by histological types has been evaluated in the atomic bomb survivors. We examined 80,158 of the 120,321 cohort members who had their radiation dose estimated by the latest dosimetry system (DS02). Potential skin tumors diagnosed from 1958 to 1996 were reviewed by a panel of pathologists, and radiation risk of the first primary skin cancer was analyzed by histological types using a Poisson regression model. A significant excess relative risk (ERR) of basal cell carcinoma (BCC) (n ¼ 123) was estimated at 1 Gy (0.74, 95% confidence interval (CI): 0.26, 1.6) for those age 30 at exposure and age 70 at observation based on a linear-threshold model with a threshold dose of 0.63 Gy (95% CI: 0.32, 0.89) and a slope of 2.0 (95% CI: 0.69, 4.3). The estimated risks were 15, 5.7, 1.3 and 0.9 for age at exposure of 0-9, 10-19, 20-39, over 40 years, respectively, and the risk increased 11% with each oneyear decrease in age at exposure. The ERR for squamous cell carcinoma (SCC) in situ (n ¼ 64) using a linear model was estimated as 0.71 (95% CI: 0

show abstract

Section: Figmentioning

confidence: 99%

Skin Cancer Incidence among Atomic Bomb Survivors from 1958 to 1996

Sugiyama

Misumi

Kishikawa³

et al. 2014

Radiation Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, artificial sources of UVR, such as PUVA therapy and indoor tanning devices, have also been implicated in the pathogenesis of cSCC [20]. Other environmental factors include X-ray radiation (as accident or historically occupational exposure) but also chemical factors such as arsenic (as a toxic agent, poison or therapy) and polycyclic hydrocarbons, mostly in the context of occupational exposure [21,22]. More rarely, very long-lasting chronic inflammatory processes such as those observed in chronic wounds, old burn or other scars, leg ulcers, sinus tracts or certain chronic genetic diseases, such as epidermolysis bullosa, may also contribute to the development of cSCC, which are often advanced due to late diagnosis.…”

Section: Risk Factorsmentioning

confidence: 99%

Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline

Stratigos

Garbe

Lebbe

et al. 2015

European Journal of Cancer

423

369

View full text Add to dashboard Cite

“…1,8,9,55,56 The most relevant behavioral and exposure factors are: unprotected professional exposure to UV rays (rural activity, fishermen and builders), sports and outdoor recreation, sunburns in youth, radiotherapy treatments, phototherapy (PUVA or UVB) and arsenic exposure. 1,2,20,41,53,54,[57][58][59][60][61][62][63][64][65] Dark hair dye colors, diets rich in fat and artificial tanning beds have been suggested in some studies as factors associated with the development of BCC, but they need to be further clarified in other studies with their own specific designs. 52,57,66 Prolonged use of photosensitizing drugs such as tetracyclines, sulfonamides, fluoroquinolones, phenothiazines, and diuretics was associated with risk of BCC in a study conducted in the USA.…”

Section: To 38mentioning

confidence: 99%

Epidemiologia do carcinoma basocelular

Chinem

Miot

2011

An. Bras. Dermatol.

122

View full text Add to dashboard Cite

Basal cell carcinoma is the most common malignant neoplasm in humans and its incidence has increased over the last decades. Its high frequency significantly burdens the health system, making the disease a public health issue. Despite the low mortality rates and the rare occurrence of metastases, the tumor may be locally invasive and relapse after treatment, causing significant morbidity. Exposure to ultraviolet radiation is the main environmental risk factor associated with its cause. However, other elements of risk are described, such as light skin phototypes, advanced age, family history of skin carcinoma, light eyes and blond hair, freckles in childhood and immunosuppression. Behavioral aspects such as occupational sun exposure, rural labor and sunburns at a young age also play a role. Between 30% and 75% of the sporadic cases are associated with patched hedgehog gene mutation, but other genetic changes are also described. The tumor is commonly found in concomitance with skin lesions related to chronic sun exposure, such as actinic keratoses, solar lentigines and facial telangiectasia. The prevention of basal cell carcinoma is based on the knowledge of risk factors, early diagnosis and treatment, as well as on the adoption of specific measures, particularly in susceptible populations. The authors present a review of the epidemiology of basal cell carcinoma. Keywords: Injections, intradermal; Review; Skin; Therapeutics Resumo: O carcinoma basocelular é a neoplasia maligna mais comum em humanos e sua incidência vem aumentando nas últimas décadas. Sua grande frequência gera significativo ônus ao sistema de saúde, configurando problema de saúde pública. Apesar das baixas taxas de mortalidade e de rara ocorrência de metástases, o tumor pode apresentar comportamento invasivo local e recidivas após o tratamento, provocando importante morbidade. Exposição à radiação ultravioleta representa o principal fator de risco ambiental associado a sua gênese. Entretanto, descrevem-se outros elementos de risco: fotótipos claros, idade avançada, história familiar de carcinomas de pele, olhos e cabelos claros, sardas na infância e imunossupressão, além de aspectos comportamentais, como exercício profissional exposto ao sol, atividade rural e queimaduras solares na juventude. Entre 30% e 75% dos casos esporádicos estão associados à mutação do gene patched hedgehog, mas outras alterações genéticas são ainda descritas. A neoplasia é comumente encontrada concomitantemente com lesões cutâneas relacionadas à exposição solar crônica, tais como: queratoses actínicas, lentigos solares e telangiectasias faciais. A prevenção do carcinoma basocelular se baseia no conhecimento de fatores de risco, no diagnóstico e tratamento precoces e na adoção de medidas específicas, principalmente, nas populações susceptíveis. Os autores apresentam uma revisão da epidemiologia do carcinoma basocelular.

show abstract

Squamous Cell and Basal Cell Carcinoma of the Skin in Relation to Radiation Therapy and Potential Modification of Risk by Sun Exposure

Abstract: Radiation treatment, particularly if experienced before age 20, seems to increase the long-term risk of both basal and squamous cell carcinomas of the skin. These risks may differ by sun exposure or host response to sunlight exposure.

Cited by 68 publications

References 27 publications

Skin Cancer Incidence among Atomic Bomb Survivors from 1958 to 1996

Skin Cancer Incidence among Atomic Bomb Survivors from 1958 to 1996

Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline

Epidemiologia do carcinoma basocelular

Contact Info

Product

Resources

About