Sputum microbiota in severe asthma patients: Relationship to eosinophilic inflammation

Abstract

Patients with asthma have an altered airway microbiota, with specific bacteria associated with severe asthma and the eosinophilic inflammatory phenotype.

The skin prick test response after allergen immunotherapy in different levels of tIgE children with mite sensitive Asthma/Rhinitis in South China

“…The reason for this is that the eosinophilia in sputum on tissue or luminal appears to be the most accurate and clinically relevant. 24 There was no statistical difference in lung function parameters, which may be attributed to the control of asthma in most children before AIT, but PC20 significantly improved after AIT as we found in another article. 25 In this study, we analyzed the relationship between serum parameters before AIT and AIT efficacy, which provided a reference for selecting the appropriate patients for AIT.…”

The crosstalk between microbiome and asthma: Exploring associations and challenges

“…Again, this might be related to the effect of corticosteroids, which by suppressing immunity would enhance the growth of diverse microbiota. However, in other studies, no significant differences in bacterial diversity were found between asthma patients and healthy controls . Other studies showed that asthmatic patients had lower airway and gut microbiome diversity when compared to healthy controls …”

“…Three studies have reported that neutrophilic asthma patients had lower sputum bacterial richness and diversity and showed higher abundances of Proteobacteria phylum especially Moraxella and Haemophilus compared with non‐neutrophilic, eosinophilic or paucigranulocytic asthma phenotypes . In contrast, eosinophilic asthma patients had higher sputum abundances of Actinobacteria phylum especially Actinomycetaceae family compared with non‐eosinophilic or neutrophilic asthma patients . The microbial dysbiosis observed between different asthma phenotypes has driven some research groups to phenotype cluster their patients based on asthma clinical and biochemical characteristics before exploring microbial dysbiosis between these phenotypes.…”

“…A study shown that children from Russian Karelia had higher overall bacterial diversity and abundance of genus Acinetobacter and were less likely to have allergic disorders including asthma, compared to children from Finland Karelia . In addition to different populations and environments, other factors related to multiple asthma phenotypes studied, asthma and non‐asthma medications used besides corticosteroids, dietary habits and age groups . Moreover, it should be noted that sample size is a huge determining factors for inconsistencies found in reported microbiome statistical differences which should be considered while designing the microbiome asthma studies.…”

Predicting Microbe-Disease Association by Learning Graph Representations and Rule-Based Inference on the Heterogeneous Network

“…Researchers also proved that colonization with Clostridium coccoides (ranked 3rd in the list) and Bacteroides (ranked 7th in the list) at 3 weeks were associated with positive predictors of asthma at age 3 (Carl et al, 2008(Carl et al, , 2011. In addition, the abundance of Firmicutes (ranked 2nd in the list) and Enterobacteriaceae (ranked 5th in the list) were higher in severe asthmatics compared with non-asthmatic people, while Actinobacteria (ranked 4th in the list) and Lachnospiraceae (ranked 9th in the list) with lower proportion (Marri et al, 2013;Ciaccio et al, 2015;Zhang et al, 2016;Li et al, 2017). Moreover, Huang et al (2018) found that Lactobacillus (ranked 6th in the list) can reduce asthma severity and improve asthma control, which is beneficial to children with asthma.…”