The skin prick test response after allergen immunotherapy in different levels of tIgE children with mite sensitive Asthma/Rhinitis in South China

Sun, Wangming; Pan, Lingzhi; Yu, Qiying; Sun, Yan; Zeng, Xiangyan; Bai, Xiaoli; Li, Mengrong

doi:10.1080/21645515.2018.1482171

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…The diagnosis of AR was carried out by our doctors following published procedures. 9 All AR patients had perennial AR history at least two years, DME skin prick test positive (the response at least 3 mm greater than the negative control 10 ), serum DME specific IgE positive (greater than 0.35 kU/l), did not use any anti-allergy therapies at least 2 weeks. The human subject demographic data are presented in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Role of FcγRI in Antigen-Dependent Eosinophil Activation in Patients With Allergic Rhinitis

Suo

Xue

et al. 2020

Am J Rhinol�Allergy

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Background The eosinophil (Eo) activation is a crucial factor evoking allergic rhinitis (AR) attacks; factors; the mechanism of triggering Eo activation remains to be further investigated. The interaction of antigen (Ag) and antibody plays a critical role in evoking allergy attacks. This study aims to elucidate the role of FcγRI, the high affinity receptor of IgG, in the Ag-mediated Eo activation. Methods Nasal lavage fluids (NLF) were collected from AR patients and healthy control (HC) subjects. Eos were isolated by flow cytometry cell sorting and analyzed by pertinent immunological approaches. Results Eos composed more than 60% of the cellular components in AR NLF. Exposure to specific Ags (sAgs) in the culture triggered Eos to release inflammatory mediators. High levels of FcγRI were detected on the surface of AR NLF Eos. Exposure to lipopolysaccharide markedly increased the FcγRI expression in naive Eos, which could be bound by Ag-specific IgG (sIgG) to form complexes on the surface of Eos; this made Eos at the sensitized status. Eos bore with the sIgG/FcγRI complexes could be activated upon exposure to sIgG in the culture; these Eos can be designated as Ag-specific Eos. Passive transfer of Ag-specific Eos resulted in profound AR response in mice upon sAg challenge. Depletion of FcγRI on Eos efficiently abolished AR response in mice. Conclusions AR Eos express high levels FcγRI, that can be bound by sIgG to make Eos sensitized. Re-exposure to specific Ags can activate the sensitized Eos.

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Section: Methodsmentioning

confidence: 99%

Role of FcγRI in Antigen-Dependent Eosinophil Activation in Patients With Allergic Rhinitis

Suo

Xue

et al. 2020

Am J Rhinol�Allergy

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“…We adopted strict operational quality control in the SPT method. In addition to the allergen allergy itself, the accuracy of the SPT results is affected by many factors, including skin reactivity, age, [ 23 ] medication, [ 24 ] needle material, [ 25 ] and manipulation. [ 26 ] The purpose of the skin scratch test is to exclude false-positive results caused by a positive skin scratch sign.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy and safety of Dermatophagoides pteronyssinus extracts used for skin prick test

Tang

Lyu

Liu

et al. 2022

Chinese Medical Journal

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Background: Dermatophagoides pteronyssinus is a common allergen causing allergic diseases in China. The aim of this study was to evaluate the efficacy and safety of D. pteronyssinus extracts produced by Peking Union Medical College Hospital (PUMCH) for the skin prick test (SPT) in the diagnosis of D. pteronyssinus allergy. Methods: A total of 910 subjects with allergic diseases were prescribed D. pteronyssinus SPT and specific sIgE (sIgE) test among the Outpatients of Department of Allergy, PUMCH from August 10, 2015 to August 30, 2017. Receiver operating characteristic curve (ROC) analysis was performed according to the results of D. pteronyssinus-sIgE detection. The accuracy of D. pteronyssinus extracts used for SPT in the diagnosis of D. pteronyssinus allergy was evaluated under different cutoff values. Adverse events after SPT were recorded to evaluate safety.Results: There were 796 and 618 subjects in the full analysis set (FAS) and the per protocol set (PPS), respectively. The areas under the curve of FAS and PPS were 0.871 and 0.873, respectively. According to the ROC of PPS, the optimal and 95% specificity diagnostic cutoff values of D. pteronyssinus SPT mean wheal diameter were 3.25 and 3.75 mm, respectively. No adverse events occurred. Conclusion:The extracts of D. pteronyssinus for SPT were simple, highly accurate, and safe and should be considered for recommendation in the clinical diagnosis of D. pteronyssinus allergy.

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“…This change is accompanied by induced blocking antibodies (particularly, of the subclass IgG4) [ 107 ]. The sIgE/tIgE ratio is often increased following AIT treatment [ 108 109 110 111 112 ], however, no changes are observed when evaluated less than 2 years of AIT treatment [ 113 ]. The blocking activity of IgG antibodies maintains unchanged for at least 2 years of discontinuation of AIT, despite the reduction in the IgG1 and IgG4 levels [ 114 ], suggesting long-term immune tolerance following cessation of AIT treatment.…”

Section: Predictive Biomarkers For Ait Outcomes In Allergic Diseasesmentioning

confidence: 99%

“…Changes in skin prick test (SPT) have a high degree of diagnostic performance in the evaluation of efficacy in HDM-SCIT according to tIgE levels [ 111 ]. Recently, one study reported the increased sensitivity and clinical relevance of the intradermal test compared to SPT to predict AIT effectiveness in respiratory allergic diseases [ 115 ].…”

Section: Predictive Biomarkers For Ait Outcomes In Allergic Diseasesmentioning

confidence: 99%

Mechanisms and biomarkers of successful allergen-specific immunotherapy

López

Imam

Satitsuksanoa

et al. 2022

Asia Pacific Allergy

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Allergen-specific immunotherapy (AIT) is considered the only curative treatment for allergic diseases mediated by immunoglobulin E (IgE). Currently, the route of administration depends both on the different types of causal allergens and on its effectiveness and safety profile. Several studies have reported the mechanisms and changes in humoral and cellular response underlying AIT; however, the full picture remains unknown. Knowledge of who can benefit from this type of treatment is urgently needed due to the patient safety risks and costs of AIT. In vivo or in vitro biomarkers have become a strategy to predict clinical outcomes in precision medicine. There are currently no standardized biomarkers that allow determining successful responses to AIT, however, some studies have found differences between responders and nonresponders. In addition, different candidates have been postulated that may have the potential to become biomarkers. In this review, we aim to summarize the findings to date related to biomarkers in different IgE-mediated allergic diseases (respiratory, food, and venom allergy) with the potential to define who will benefit from AIT.

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The skin prick test response after allergen immunotherapy in different levels of tIgE children with mite sensitive Asthma/Rhinitis in South China

Abstract: The SPT grade change can be used for efficacy evaluation. Children with lower level of tIgE and higher ratio of sIgE/tIgE that obtain a more satisfactory effect.

Cited by 10 publications

References 23 publications

Role of FcγRI in Antigen-Dependent Eosinophil Activation in Patients With Allergic Rhinitis

Role of FcγRI in Antigen-Dependent Eosinophil Activation in Patients With Allergic Rhinitis

Diagnostic accuracy and safety of Dermatophagoides pteronyssinus extracts used for skin prick test

Mechanisms and biomarkers of successful allergen-specific immunotherapy

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