Spread of OXA-48-mediated resistance to carbapenems in LebaneseKlebsiellapneumoniaeandEscherichiacolithat produce extended spectrum β-lactamase

Matar, Ghassan M.; Dandache, Israa; Carrër, Amélie; Khairallah, Marie-Therese; Nordmann, Patrice; Sabra, Ahmad; Araj, George F.

doi:10.1179/136485910x12647085215651

Cited by 44 publications

(28 citation statements)

References 11 publications

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“…It is noteworthy, however, that although sporadic cases of OPE in adults have been described in Israel (3), the first and so far the only OPE outbreak in Israel occurred in the pediatric population. The data regarding the prevalence of OPE in the PA and Gaza are limited, but based on this study and our previous report (3), it appears likely that OPE is endemic to these areas, similar to the situation in other Middle Eastern countries (1,17). Due to the fact that several months elapsed between onset of the outbreak and the involvement of the MoH, we were unable to obtain the microbiological data necessary to determine the origin of the outbreak.…”

Section: Discussionmentioning

confidence: 72%

Epidemiological and Microbiological Characteristics of an Outbreak Caused by OXA-48-Producing Enterobacteriaceae in a Neonatal Intensive Care Unit in Jerusalem, Israel

et al. 2013

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dThis study describes the course of an OXA-48-producing Enterobacteriaceae (OPE) outbreak that started in March 2012 in a neonatal intensive care unit (NICU) in Jerusalem, Israel. During the peak of the outbreak (January to August 2012), there were 49 patients who had proven or suspected acquisition of OPE in the NICU, including 16 with invasive infections, out of a total of 156 patients who were hospitalized during that period. Three children hospitalized in the pediatric ICU were identified as carriers of OPE. Three patients with a previous stay in the affected NICU were identified as OPE carriers upon admission to another hospital. The Ministry of Health was notified and then intervened in July 2012. Intervention included cohorting colonized patients, conducting frequent rectal-culture surveillance, and improving the implementation of infection control practices. As a result, the incidence of OPE acquisition declined to 5 cases in the first 4 months, followed by no new cases in the next 3 months. Thirty-one patient-unique isolates were available for analysis: 29 Klebsiella pneumoniae isolates, all belonging to a single clone (sequence type 39 [ST39]), and 2 isolates from Enterobacter cloacae. All isolates possessed the bla OXA-48 and bla CTX-M-14 genes, which are located on the same plasmid. This plasmid, similar to the global bla OXA-48 -harboring vector, has now acquired bla CTX-M-14 , leading to resistance to all ␤-lactam agents.

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Section: Discussionmentioning

confidence: 72%

Epidemiological and Microbiological Characteristics of an Outbreak Caused by OXA-48-Producing Enterobacteriaceae in a Neonatal Intensive Care Unit in Jerusalem, Israel

et al. 2013

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“…In Lebanon, theses carbapenemases are OXA-48 from both K. pneumoniae and E. coli. In 2009 a study among ESBL isolates showed that 2.5% of E. coli and 7.84% of K. pneumoniae were carbapenem resistant [2,3]. The carbapenemases described in Turkey were the OXA-48 and VIM-5 [1,[6][7].…”

Section: Discussionmentioning

confidence: 99%

“…In the Middle East, including Lebanon, such reports are very scarce [2,3]. Herein, we give an account of three patients from Iraq presenting to our institution, and from whom carbapenemase-producing Escherichia coli or Klebsiella pneumoniae were recovered.…”

Section: Introductionmentioning

confidence: 99%

Detection of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae producing NDM-1 in Lebanon

El-Herte

Araj

Matar

et al. 2012

J Infect Dev Ctries

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Carbapenem resistance has been encountered globally with poor outcome of infected patients. NDM-1 (New Delhi metallo-beta-lactamase) gene containing organisms have emerged and are now spreading in all continents. This is the first report of Iraqi patients referred to Lebanon from whom carbapenem resistant Enterobacteriaceae were recovered. The genes involved in carbapenem resistance were bla-OXA-48 and the novel NDM-1. This report highlights the alarming introduction of such resistance among Enterobacteriaecae to this country.

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“…Escherichia coli strains producing OXA-48 were reported in several countries, especially in the Mediterranean basin region (2), including Lebanon (3). Different E. coli clones have successfully emerged in the world; examples are E. coli O15:K52:H1-D of sequence type 393 (ST393) (4), E. coli ST131 (5), and E. coli ST38, which is characterized by the production of the OXA-48 ␤-lactamase and is related to strains of the Mediterranean basin countries (2, 6).…”

mentioning

confidence: 99%

Emergence of OXA-48-Producing Escherichia coli Clone ST38 in Fowl

Al-Bayssari

Olaitan

Dabboussi

et al. 2015

Antimicrob Agents Chemother

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Spread of OXA-48-mediated resistance to carbapenems in LebaneseKlebsiellapneumoniaeandEscherichiacolithat produce extended spectrum β-lactamase

Cited by 44 publications

References 11 publications

Epidemiological and Microbiological Characteristics of an Outbreak Caused by OXA-48-Producing Enterobacteriaceae in a Neonatal Intensive Care Unit in Jerusalem, Israel

Epidemiological and Microbiological Characteristics of an Outbreak Caused by OXA-48-Producing Enterobacteriaceae in a Neonatal Intensive Care Unit in Jerusalem, Israel

Detection of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae producing NDM-1 in Lebanon

Emergence of OXA-48-Producing Escherichia coli Clone ST38 in Fowl

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