2017
DOI: 10.3201/eid2302.161149
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Spread and Evolution of Respiratory Syncytial Virus A Genotype ON1, Coastal Kenya, 2010–2015

Abstract: In February 2012, the novel respiratory syncytial virus (RSV) group A, genotype ON1, was detected in Kilifi County, coastal Kenya. ON1 is characterized by a 72-nt duplication within the highly variable G gene (encoding the immunogenic attachment surface protein). Cases were diagnosed through surveillance of pneumonia in children at the county hospital. Analysis of epidemiologic, clinical, and sequence data of RSV-A viruses detected over 5 RSV seasons (2010/2011 to 2014/2015) indicated the following: 1) replace… Show more

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Cited by 62 publications
(78 citation statements)
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“…The novel ON1 genotype was first detected in December 2010, in Ontario, Canada [ 13 ]. Studies from Italy [ 65 ], China [ 54 ], Senegal [ 55 ] and Kenya [ 66 ] report on the occurrence of ON1 for the years 2011, 2012 or 2013, suggesting that ON1 strains might have been introduced into Ghana before 2013. For the two years of HRSV group B detections in Ghana, almost all HRSV-B strains clustered within genotype BA9.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The novel ON1 genotype was first detected in December 2010, in Ontario, Canada [ 13 ]. Studies from Italy [ 65 ], China [ 54 ], Senegal [ 55 ] and Kenya [ 66 ] report on the occurrence of ON1 for the years 2011, 2012 or 2013, suggesting that ON1 strains might have been introduced into Ghana before 2013. For the two years of HRSV group B detections in Ghana, almost all HRSV-B strains clustered within genotype BA9.…”
Section: Discussionmentioning
confidence: 99%
“…It appears that the rise of genotype ON1 not only displaced NA1 strains but also excluded group B strains. Similarly, the introduction of ON1 resulted in a replacement of HRSV-A genotype GA2 and, moreover, in a change of the HRSV subgroup alternation pattern (AAB → AAA) in Kilifi, Kenya, in the season 2012/13 [ 66 ]. However, reasons for this effect are so far unknown [ 66 ].…”
Section: Discussionmentioning
confidence: 99%
“…The inter‐rater agreement for study selection was high ( κ = 0.81). Finally, 66 full texts including 67 studies were included (one paper included two studies) …”
Section: Resultsmentioning
confidence: 99%
“…Further genetic analysis of the nucleotide sequence of the second hypervariable region on the G gene allowed for the classification into genotypes within antigenic groups RSV-A and B [9,10]. Many studies have reported the molecular epidemiology and genetic variability of RSV worldwide [10,11,12,13,14,15,16,17,18,19,20], revealing the emergence and spread of new genotypes with duplication of ~60 to 70 nucleotides in this G hypervariable region for RSV-A (RSV Ontario) and RSV-B (RSV Buenos Aires) [15,19,21,22]. Although none of the variants or genotypes has been consistently associated with greater virulence or pathogenicity [13,18,22,23], some recent reports describing clinical aspects of contemporary genotypes (NA1 and ON1) have shown higher frequencies of LRTI and hospitalizations rates [24,25,26].…”
Section: Introductionmentioning
confidence: 99%