Spray Drying Technique. I: Hardware and Process Parameters

Cal, Krzysztof; Sollohub, Krzysztof

doi:10.1002/jps.21886

Cited by 302 publications

(210 citation statements)

References 23 publications

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“…Spray drying is a well-known method of particle production which consists on the transformation of a fluid material into dried particles, taking advantage of a gaseous hot drying medium [1]. Its first observation is dated 1860 and a primitive spray dryer device was patented by Samuel Percy in United States in 1872 [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

117

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Spray drying is a well-known method of particle production which comprises the transformation of a fluid material into dried particles, taking advantage of a gaseous hot drying medium, with clear advantages for the fabrication of medical devices. In fact, it is quite common the production of microspheres and microcapsules designed for drug delivery systems. This review describes the different stages of the mechanism of the spray-drying process: atomization, droplet-to-particle conversion and particle collection. In particular, this work addresses the diversity of available atomizers, the drying kinetics and the importance of the configuration of the drying chamber, and the efficiency of the collection devices. The final properties of the dried products are influenced by a variety of factors, namely the spray dryer design, the feed characteristics and the processing parameters. The impact of those variables in optimizing both the spray-drying process and the synthesis of dried particles with desirable characteristics is discussed. The scalability of this manufacturing process in obtaining dried particles in submicron-to-micron scale favors a variety of applications within the food, chemical, polymeric, pharmaceutical, biotechnology and medical industries.

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Section: Introductionmentioning

confidence: 99%

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

117

View full text Add to dashboard Cite

show abstract

“…10,11 Spraydrying has been used to increase drug solubility and bioavailability of active substances, modified release. 12,13 Microparticles can be used for the controlled release of drugs, vaccines, antibiotics, and hormones. One of the most commonly used excipient for microencapsulation purpose is chitosan (CS), it is a naturally occurring nontoxic, biocompatible, biodegradable, cationic polysaccharide.…”

Section: Introductionmentioning

confidence: 99%

Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet

Rv¹,

Pande²,

Sonawane³

2015

Adv Pharm Bull

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“…SD technologies are energy consuming, heat-sensitive APIs can be decomposed during the drying process, and furthermore, the separation and handling of the produced fine powder can cause difficulties (Broadhead et al, 1992;Cal and Sollohub, 2010).…”

Section: Drying (Sd) and Electrospinning (Es)mentioning

confidence: 99%

Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions

Sóti

Bocz

Pataki

et al. 2015

International Journal of Pharmaceutics

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Three solvent based methods: spray drying (SD), electrospinning (ES) and air-assisted electrospinning (electroblowing; EB) were used to prepare solid dispersions of itraconazole and Eudragit E. Samples with the same API/polymer ratios were prepared in order to make the three technologies comparable. The structure and morphology of solid dispersions were identified by scanning electron microscopy and solid phase analytical methods such as, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and Raman chemical mapping. Moreover, the residual organic solvents of the solid products were determined by static headspace-gas chromatography/mass spectroscopy measurements and the wettability of samples was characterized by contact angle measurement. The pharmaceutical performance of the three dispersion type, evaluated by dissolution tests, proved to be very similar. According to XRPD and DSC analyses, made after the production, all the solid dispersions were free of any API crystal clusters but about 10 wt% drug crystallinity was observed after three months of storage in the case of the SD samples in contrast to the samples produced by ES and EB in which the polymer matrix preserved the API in amorphous state.

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Spray Drying Technique. I: Hardware and Process Parameters

Cited by 302 publications

References 23 publications

Spray Drying: An Overview

Spray Drying: An Overview

Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet

Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions

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