Spray drying of silica microparticles for sustained release application with a new sol-gel precursor

Wang, Bifeng; Frieß, Wolfgang

doi:10.1016/j.ijpharm.2017.09.016

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…Nano spray drying is also applied as a process to dry preformed NPs, such as SLNs, [157][158][159][160][161] nanoemulsions, 162,163 nanogels, 164,165 self-assembled polymeric micelles, 166 lipid-polymer hybrid NPs, 167 or silica particles formed by sol-gel processing. 168 In many cases, the preformed NPs are mixed with excipients and dispersing agents before nano spray drying to produce fine powders with improved encapsulation efficiency.…”

Section: Nano Spray Drying Of Preformed Npsmentioning

confidence: 99%

“…Wang and Friess used nano spray drying to produce water-soluble silica gel carrier particles based on a new silicate-based precursor. 168 Dextrans with different molecular weights (1, 5, and 60 kDa) were incorporated as model compounds to regulate the release kinetics. A sustained release over 35 days could be achieved using 60 kDa dextran.…”

Section: Nano Spray Drying Of Preformed Npsmentioning

confidence: 99%

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Nano Spray-Dried Drugs for Oral Administration: A Review

Öztürk

Arpagaus

2021

ASSAY and Drug Development Technologies

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Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. The key advantage of nano spray drying is the production of drug-loaded nanosized particles for various drug delivery applications. The recent developments in nano spray dryer technology and the market launch of the Nano Spray Dryer B-90 by Bu ¨chi Labortechnik AG in 2009 enabled the production of submicron spray-dried particles. This review focuses on nanosized drug delivery systems intended for oral administration produced by nano spray drying. First, the nano spray drying concept, the basic technologies implemented in the equipment, and the effects of the various process parameters on the final dry submicron powder properties are presented. Then, the topics of new formulation strategies of oral drugs are highlighted with examples that have entered the research literature in recent years. Next, the subjects of direct conversion of poorly watersoluble drugs, encapsulation of drugs, and drying of preformed nanoparticles are considered. Finally, topics such as morphology, particle size, size distribution, surface analysis, bioavailability, drug release, release kinetics, and solid-state characterization (by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, nuclear magnetic resonance) of oral drug delivery systems produced by nano spray drying are discussed. The review attempts to provide a comprehensive knowledge base with current literature and foresight to researchers working in the field of pharmaceutical technology and nanotechnology and especially in the field of nano spray drying.

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Section: Nano Spray Drying Of Preformed Npsmentioning

confidence: 99%

Section: Nano Spray Drying Of Preformed Npsmentioning

confidence: 99%

Nano Spray-Dried Drugs for Oral Administration: A Review

Öztürk

Arpagaus

2021

ASSAY and Drug Development Technologies

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“…In addition to being used to aid drug solubilization, polymeric micelles can also improve drug stability, control drug release, optimize drug distribution, prolonged blood circulation time, and passively target cancer cells via the EPR effect, thus reducing side effects and improving therapeutic effects. [30][31][32][33][34] Recently, there have been many nano-sized macromolecular anticancer drugs developed based on the EPR effect, such as Genexol-PM ® , which came to market in 2006 and is infused intravenously in clinical use. Genexol-PM ® is a novel polymeric micelle formulated paclitaxel using biodegradable block copolymer.…”

Section: Introductionmentioning

confidence: 99%

<p>Improved Antitumor Outcomes for Colon Cancer Using Nanomicelles Loaded with the Novel Antitumor Agent LA67</p>

Cui¹,

Jin²,

Han³

et al. 2020

IJN

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Background: LA67 is a derivative of triptolide that exhibits strong antitumor activity. This derivative has a better safety profile than triptolide, but is limited by poor aqueous solubility. Aim and Methods: To improve solubility and further increase therapeutic efficacy, we prepared LA67-loaded polymeric micelles (LA67-PMs) using a film hydration method. The physicochemical properties of LA67-PMs were investigated, and the antitumor activity of this formulation against Colon26 (C26) cancer cell line was evaluated in vitro and in vivo with LA67 as a control. Results: Polymeric micelles containing LA67 had a particle size of 17.88 nm and a drug entrapment efficiency of 94.84%. This formulation dispersed completely in aqueous solution and exhibited slow, sustained release of LA67. Cellular uptake assay showed that LA67-PMs delivered LA67 to cancer cells with greater efficiency than free LA67, which resulted in increased LA67 accumulation in cancer cells. Cell counting kit 8 (CCK-8) assay showed that blank polymeric micelles (PMs) exhibited low toxicity and LA67-PMs exerted pronounced antiproliferation effects against C26 cells. Furthermore, LA67-PMs induced apoptosis and repressed migration more effectively than free LA67. In vivo evaluation of antitumor activity showed that LA67-PMs inhibited tumor growth and distant organ metastasis to a greater extent than LA67, which resulted in improved survival rate. The potential mechanisms of these effects may have been induction of apoptosis, inhibition of cell proliferation, and neovascularization. Conclusion: Our study showed that LA67-PMs may be a promising formulation for treatment of colon cancer.

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“…Spray drying of colloidal precursors containing silica particles has been reported by several researchers (Waldron et al, 2014;Dixit et al, 2016). The reported applications of silica particles from spray drying include their use as catalysts and absorbents, as well as in chromatography and drug delivery systems (Bahadur et al, 2011;Wang & Friess, 2017). Iskandar et al (2003) used an aerosol-assisted spray method to produce silica particles, using a commercial colloidal silica suspension as the precursor.…”

Section: Introductionmentioning

confidence: 99%

Volume Fraction Dependent Morphological Transition of Silica Particles Derived from Sodium Silicate

Qomariyah¹,

Widiyastuti²,

Winardi³

et al. 2019

IJTech

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The volume fraction dependent morphological transition of droplets during the evaporation of colloidal silica solution was investigated using the spray-drying method. The colloidal solution was prepared from sodium silicate using the sol-gel method. Spray drying with a tubular reactor was used in the experiment, with the volume fraction of the colloidal silica varying from 15 to 2%. It was demonstrated that a morphological transition from a sphere shape to a donut-like shape takes place at a colloidal volume fraction of between 4% and 2%, even when the drying rate remains moderate and is not extremely fast. A spherical silica particle shape was found at a colloidal volume fraction of between 15% and 8%. The morphological transition depends strongly on the volume fraction of the colloids in the droplets. Further, the ζ-potential of the particles in the droplet also affects the transition by applying an interparticle electrostatic force. The same high surface charge of sol silica provides a repulsive interaction between the sol particles inside the droplet. The transition is hindered when the colloid volume fraction is increased because of the inherent spatial constraint. The Fourier-transform infrared (FT-IR) spectra of both the spherical and donut-like particles confirm the chemical bonding of the powder silica product. Moreover, X-ray diffractometry (XRD) analysis revealed an amorphous phase of the silica particles produced from spray drying. These preliminary results open up a new path for controlling the formation of a wide variety of silica particles using the spray-drying method. In addition, the different silica particle morphologies enable a variety of particle applications.

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Spray drying of silica microparticles for sustained release application with a new sol-gel precursor

Cited by 11 publications

References 28 publications

Nano Spray-Dried Drugs for Oral Administration: A Review

Nano Spray-Dried Drugs for Oral Administration: A Review

<p>Improved Antitumor Outcomes for Colon Cancer Using Nanomicelles Loaded with the Novel Antitumor Agent LA67</p>

Volume Fraction Dependent Morphological Transition of Silica Particles Derived from Sodium Silicate

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