Spray drying modelling based on advanced droplet drying kinetics

Mezhericher, Maksim; Levy, Avi; Borde, I.

doi:10.1016/j.cep.2010.09.002

Cited by 88 publications

(41 citation statements)

References 18 publications

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“…Several papers have been published on the development of a spray dryer model to facilitate a shift from trial-and-error to quality-by-design [3]–[6]. Unfortunately, the models that are presented in these studies are often either based on very complex computational fluid dynamics (CFD) [7] or they are developed in expensive and specialized software [3]. Although these models are useful for many applications, the details of the models and the complexity of the software far exceeds that required for standard pharmaceutical product development.…”

Section: Introductionmentioning

confidence: 99%

A User-Friendly Model for Spray Drying to Aid Pharmaceutical Product Development

et al. 2013

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The aim of this study was to develop a user-friendly model for spray drying that can aid in the development of a pharmaceutical product, by shifting from a trial-and-error towards a quality-by-design approach. To achieve this, a spray dryer model was developed in commercial and open source spreadsheet software. The output of the model was first fitted to the experimental output of a Büchi B-290 spray dryer and subsequently validated. The predicted outlet temperatures of the spray dryer model matched the experimental values very well over the entire range of spray dryer settings that were tested. Finally, the model was applied to produce glassy sugars by spray drying, an often used excipient in formulations of biopharmaceuticals. For the production of glassy sugars, the model was extended to predict the relative humidity at the outlet, which is not measured in the spray dryer by default. This extended model was then successfully used to predict whether specific settings were suitable for producing glassy trehalose and inulin by spray drying. In conclusion, a spray dryer model was developed that is able to predict the output parameters of the spray drying process. The model can aid the development of spray dried pharmaceutical products by shifting from a trial-and-error towards a quality-by-design approach.

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Section: Introductionmentioning

confidence: 99%

A User-Friendly Model for Spray Drying to Aid Pharmaceutical Product Development

et al. 2013

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“…At the inlet temperatures were 180 °C and 190 °C have produced microcapsules rough surface and wrinkled. This happens because, at low temperatures, the drying rate would decrease so that the solidification process of microcapsules would take longer [44,45]. Wrinkles microcapsules could be caused by the diffusion of oleoresin from the microcapsules because of slow drying rate.…”

Section: Encapsulation Efficiencymentioning

confidence: 99%

Encapsulation of Red Ginger Oleoresin (Zingiber Officinale Var Rubrum) With Chitosan as Wall Material

Jayanudin

Rochmadi

2017

Int J Pharm Pharm Sci

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Objective: This research aims to determine the effect of the spray drying condition against encapsulation efficiency and characterization microcapsules of red ginger oleoresin. Methods:Preparation of encapsulation begun with the formation of emulsions by mixing red ginger oleoresin with chitosan solution which was dissolved with acetic acid 2% (v/v). The weight ratio of chitosan with red ginger oleoresin was 1: 1, 2: 1 and 3: 1 and then stirred using a homogenizer while added 2 ml tween 80 for 10 min. The size of emulsion droplet was measured using nanoparticle analyzer (NPA). The emulsion is formed and then inserted into the feed tank of a spray dryer. Inlet temperature of the spray dryer used in the 180 °C, 190 °C and 200 °C; and the spray dryer outlet temperature was 85 °C, feed rate at 2 L/h. The microcapsules formed were then analyzed Results: Based on the research that has been done, the smallest effective diameter of the emulsion droplets encapsulation efficiency and characterization using scanning electron microscopy (SEM) and fourier transform infrared spectroscopy (FTIR).

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“…As a first step in the development of this new model, a spray sub-model is needed that describes the generation, the motion and the heat and mass transfer of the droplets in the coating process. Spray models have been widely investigated for decades and can be found in the literature for a broad range of applications: fuel vaporisation in combustion engines (Furuhata et al, 1997), evaporative cooling of droplets in cooling towers (Fisenko et al, 2002) and spray drying processes (Mezhericher et al, 2010). Most of the spray models encountered in the literature are based on the two-phase flow Eulerian-Lagrangian approach in which all the droplets in the spray are considered.…”

Section: Introductionmentioning

confidence: 99%