Spray Drying for the Preparation of Nanoparticle-Based Drug Formulations as Dry Powders for Inhalation

Malamatari, Maria; Charisi, Anastasia; Malamataris, S.; Kachrimanis, Kyriakos; Nikolakakis, Ioannis

doi:10.3390/pr8070788

Cited by 89 publications

(57 citation statements)

References 110 publications

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“…Nowadays, there is a wide range of the available classical DPIs in the markets, and the number will keep increasing. The main differences among these DPIs lie in their design, airflow resistances, formulations’ type and excipients, and dry powder production techniques and dispersion methods [ 76 , 77 ]. These mentioned device and formulations related-variables, in addition to the patient-related variations such as the patient’s respiratory health and performance, may significantly affect the performance of these devices and lead to some variations in their drug deposition efficiencies into the lungs [ 78 ].…”

Section: Devices For the Pulmonary Drug Delivery Of Anticancer Drug-loaded Lipid-based Nanocarriersmentioning

confidence: 99%

Pulmonary Delivery of Anticancer Drugs via Lipid-Based Nanocarriers for the Treatment of Lung Cancer: An Update

et al. 2021

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Lung cancer (LC) is the leading cause of cancer-related deaths, responsible for approximately 18.4% of all cancer mortalities in both sexes combined. The use of systemic therapeutics remains one of the primary treatments for LC. However, the therapeutic efficacy of these agents is limited due to their associated severe adverse effects, systemic toxicity and poor selectivity. In contrast, pulmonary delivery of anticancer drugs can provide many advantages over conventional routes. The inhalation route allows the direct delivery of chemotherapeutic agents to the target LC cells with high local concertation that may enhance the antitumor activity and lead to lower dosing and fewer systemic toxicities. Nevertheless, this route faces by many physiological barriers and technological challenges that may significantly affect the lung deposition, retention, and efficacy of anticancer drugs. The use of lipid-based nanocarriers could potentially overcome these problems owing to their unique characteristics, such as the ability to entrap drugs with various physicochemical properties, and their enhanced permeability and retention (EPR) effect for passive targeting. Besides, they can be functionalized with different targeting moieties for active targeting. This article highlights the physiological, physicochemical, and technological considerations for efficient inhalable anticancer delivery using lipid-based nanocarriers and their cutting-edge role in LC treatment.

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Section: Devices For the Pulmonary Drug Delivery Of Anticancer Drug-loaded Lipid-based Nanocarriersmentioning

confidence: 99%

Pulmonary Delivery of Anticancer Drugs via Lipid-Based Nanocarriers for the Treatment of Lung Cancer: An Update

et al. 2021

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“…The lower density of DPI particles could offer better flowability and improved deposition within the deeper airways. Thanks to the additives, the density was reduced to under 0.3 g/cm 3 . The usual density of DPIs is about 1 g/cm 3 , so our samples can be considered as low-density formulation.…”

Section: Powder Rheologymentioning

confidence: 99%

“…Thanks to the additives, the density was reduced to under 0.3 g/cm 3 . The usual density of DPIs is about 1 g/cm 3 , so our samples can be considered as low-density formulation. The lower the tap density (0.04-0.25 g/cm 3 ), the greater the respirable fraction [43].…”

Section: Powder Rheologymentioning

confidence: 99%

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Formulation and In Vitro and In Silico Characterization of “Nano-in-Micro” Dry Powder Inhalers Containing Meloxicam

et al. 2021

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Pulmonary delivery has high bioavailability, a large surface area for absorption, and limited drug degradation. Particle engineering is important to develop inhalable formulations to improve the therapeutic effect. In our work, the poorly water-soluble meloxicam (MX) was used as an active ingredient, which could be useful for the treatment of non-small cell lung cancer, cystic fibrosis, and chronic obstructive pulmonary disease. We aimed to produce inhalable “nano-in-micro” dry powder inhalers (DPIs) containing MX and additives (poly-vinyl-alcohol, leucine). We targeted the respiratory zone with the microcomposites and reached a higher drug concentration with the nanonized active ingredient. We did the following investigations: particle size analysis, morphology, density, interparticular interactions, crystallinity, in vitro dissolution, in vitro permeability, in vitro aerodynamics (Andersen cascade impactor), and in silico aerodynamics (stochastic lung model). We worked out a preparation method by combining wet milling and spray-drying. We produced spherical, 3–4 µm sized particles built up by MX nanoparticles. The increased surface area and amorphization improved the dissolution and diffusion of the MX. The formulations showed appropriate aerodynamical properties: 1.5–2.4 µm MMAD and 72–76% fine particle fraction (FPF) values. The in silico measurements proved the deposition in the deeper airways. The samples were suitable for the treatment of local lung diseases.

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“…Surprisingly, different geometric shapes of Ag particles, such as polyhedron and cylinder-like, adhered to the Si film (Figure 5C,D). This action was possibly due to the agglomeration and cohesion of grains during the curing process [84]. A change in chemical reaction and interconnection between the Ag grains promoted the tightly packed and oversized grain particles.…”

Section: Morphological Analysis Of Si-ag Thin Filmsmentioning

confidence: 99%

Synthesis, Characterisation and Antibacterial Properties of Silicone–Silver Thin Film for the Potential of Medical Device Applications

et al. 2021

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Silver (Ag) particles have sparked considerable interest in industry and academia, particularly for health and medical applications. Here, we present the “green” and simple synthesis of an Ag particle-based silicone (Si) thin film for medical device applications. Drop-casting and peel-off techniques were used to create an Si thin film containing 10–50% (v/v) of Ag particles. Electro impedance spectroscopy (EIS), X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), and tensile tests were used to demonstrate the electrical conductivity, crystallinity, morphology-elemental, and mechanical properties, respectively. The oriented crystalline structure and excellent electronic migration explained the highest conductivity value (1.40 × 10−5 S cm−1) of the 50% Ag–Si thin film. The findings regarding the evolution of the conductive network were supported by the diameter and distribution of Ag particles in the Si film. However, the larger size of the Ag particles in the Si film resulted in a lower tensile stress of 68.23% and an elongation rate of 68.25% compared to the pristine Si film. The antibacterial activity of the Ag–Si film against methicillin-resistant Staphylococcus aureus (MRSA), Bacillus cereus (B. cereus), Klebsiella pneumoniae (K. pneumoniae), and Pseudomonas aeruginosa (P. aeruginosa) was investigated. These findings support Si–Ag thin films’ ability to avoid infection in any medical device application.

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Spray Drying for the Preparation of Nanoparticle-Based Drug Formulations as Dry Powders for Inhalation

Cited by 89 publications

References 110 publications

Pulmonary Delivery of Anticancer Drugs via Lipid-Based Nanocarriers for the Treatment of Lung Cancer: An Update

Pulmonary Delivery of Anticancer Drugs via Lipid-Based Nanocarriers for the Treatment of Lung Cancer: An Update

Formulation and In Vitro and In Silico Characterization of “Nano-in-Micro” Dry Powder Inhalers Containing Meloxicam

Synthesis, Characterisation and Antibacterial Properties of Silicone–Silver Thin Film for the Potential of Medical Device Applications

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