Spray Dried Amorphous Form of Simvastatin: Preparation and Evaluation of the Buccal Tablet

Abstract

Background: The success of a drug primarily depends on its bioavailability. By enhancing the solubility and dissolution properties of drugs that are scarcely water soluble, significantly improves their bioavailability. Methods: This study was aimed to prepare a solid dispersion of the drug simvastatin that is a poorly water-soluble drug, through the spray drying technique. Solid dispersion carrier PVP, adsorbent Aerosil 200 and solvent dichloromethane were used to prepare solid dispersion. The pure simvastatin, solid dispersion and physical mixture were analyzed using FTIR, XRD and DSC studies. IR studies confirmed the possibility of hydrogen bonding in solid dispersion. Results: XRD and DSC studies revealed that the amorphous form of simvastatin was present in the solid dispersion. The spray dried form of simvastatin was formulated into a buccal tablet by using carbopol 934 and HPMC K4M as mucoadhesive polymers. The drug release from buccal tablets indicated that improvement in solubility, the rate of dissolution of poorly water-soluble drug simvastatin. Conclusion: The study shows that the tremendous potential of solid dispersions of simvastatin by using spray drying technique.

Improvement of Osseointegration by Ultraviolet and/or Simvastatin Treatment on Titanium Implants with or without Bone Graft Materials

“…Figure 5 shows the FTIR spectra of the titanium discs. The spectrum of the disc immersed in simvastatin solution resembled that of simvastatin reported in the literature [63,64]. The prominent bands of the OH stretching vibrations (3600-3200 cm −1 ) and the carbonyl C=O stretching vibration (1800-1600 cm −1 ) were observed.…”

“…The spectral analysis confirmed the alteration of the surface of the titanium disc upon simvastatin treatment from a chemical perspective. [63,64]. The prominent bands of the OH stretching vibrations (3600-3 carbonyl C=O stretching vibration (1800-1600 cm −1 ) were observed.…”

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

“…The inclusion of cellulosic or acrylic polymers generally results in rapid and prolonged bioadhesion even with high drug entrapment. Most commonly used hydrogel-based polymers for buccal delivery dosage forms are hydroxyethyl cellulose, carboxymethyl cellulose, HPMC, HPC, chitosan, polyacrylic resins and PVA, polyvinylpyrrolidone, Kollicoat, PROLOC™, maltodextrins, Lycoat NG 73, and pullulan [ 134 , 139 , 140 , 141 ]. Nanocarriers loaded into hydrogels are used for buccal delivery to improve the residence time, bioavailability as well as to protect the drug degradation.…”

Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation

“…Th thickness of the prepared films (F1–F4) at five diverse locations was measured using a digital micrometer (MDH-25M, Mitutoyo, Kawasaki, Japan). The surface pH was measured by randomly selecting three films having a surface area of 1 cm 2 from each prepared batch and permitting them to swell in 5 mL of distilled water for 30 min [ 29 ]. The pH was determined using a Thermo Fischer Benchtop pH meter.…”