Spray congealed lipid microparticles with high protein loading: Preparation and solid state characterisation

The effect of polymer coatings on physicochemical properties of spray-dried liposomes for nasal delivery of BSA

“…The α-helix content of the BSA standard solution was 62.1%, in agreement with the literature (Di Sabatino et al, 2012). The negative control heat treatment at 80 °C for 1h…”

A study on the solid state characteristics of spray-congealed glyceryl dibehenate solid lipid microparticles containing ibuprofen

“…Hydrophilic matrix materials, often used for enhancing drug release, include various grades of polyethylene glycols 25 , poloxamers 26 and gelucires 27 . On the other hand, hydrophobic matrix materials have been used for taste masking and sustaining drug release, and include waxes 28 , glycerides 29 , hydrogenated vegetable oils 30 and fatty acids 31 . Typically, formulations for spray congealing consist of the matrix material, active substance(s) with or without other additives such as those used as release modifiers.…”

Spray congealing as innovative technique for enzyme encapsulation

“…The mean size of the microparticles obtained was 40–55 μm while the average size was found between 25 and 35 μm. The research group of Passerini, which developed a special spray congealing apparatus, obtained particles with a mean diameter of 150–300 μm . The sizes were mainly based on the different diameters of the spraying nozzle, which was 2.0 mm in our study, much smaller than the diameter of 4.5 mm in the studies of Passerini et al .…”