The effect of polymer coatings on physicochemical properties of spray-dried liposomes for nasal delivery of BSA

Chen, K.H.; Sabatino, Marcello Di; Albertini, Beatrice; Passerini, Nadia; Kett, Vicky L.

doi:10.1016/j.ejps.2013.07.006

Cited by 39 publications

(17 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…46 The in vitro drug release was measured via the dialysis bag diffusion method which is one of the most commonly used dissolution methods for the testing of nanoformulations designed for nasal drug delivery. [47][48][49] SVT-LCN_MaiLab were chosen for testing due to their optimal EE of drug and suitable physicochemical features, and a suspension of simvastatin was used as control. The simvastatin release profile from SVT-LCN_MaiLab can be seen in Figure 6.…”

Section: Simvastatin Release Studiesmentioning

confidence: 99%

The nasal delivery of nanoencapsulated statins – an approach for brain delivery

Clementino¹,

Batger²,

Garrastazu³

et al. 2016

IJN

View full text Add to dashboard Cite

Section: Simvastatin Release Studiesmentioning

confidence: 99%

The nasal delivery of nanoencapsulated statins – an approach for brain delivery

Clementino¹,

Batger²,

Garrastazu³

et al. 2016

IJN

View full text Add to dashboard Cite

“…33,34 Although both powders had respective narrow span values 1.91 and 1.7, F2 showed significantly larger size than F9: volume mean diameter of 2.8 and 1.26 µm, respectively (P0.05), suggesting suitability for nasal delivery. 35 REP was highly incorporated in the SDP, with respective incorporation efficiencies of 93.19% and 94.36%. Sustained REP release after 6 hours, amounting of 61.47% and 68.62%, respectively, from F2 and F9, was found with non-significant difference between them (P0.05) (see profiles in Figure 2).…”

Section: Spray-dried Ncs In Mps Characterizationmentioning

confidence: 98%

Nanocomplexes of an insulinotropic drug: optimization, microparticle formation, and antidiabetic activity in rats

Elmowafy¹,

Osman²,

El-Shamy³

et al. 2014

IJN

View full text Add to dashboard Cite

The aim of the present work was to test the ability of two non-diabetogenic carbohydrates to intranasally deliver the insulinotropic drug repaglinide (REP) for controlling blood glucose level. REP was loaded onto chitosan/alginate nanocomplexes (NCs) suitable for mucosal delivery and uptake. Improved stability and delivery characteristics were obtained by spray drying the selected NCs, yielding microparticles. A statistical experimental design was adopted to investigate the effects of the formulations’ variables on two critical responses: NC size and drug entrapment efficiency. Physicochemical characterizations of the network’s structures were done, and in vitro cytotoxicity and histopathological studies were conducted. The potential of the developed system to prolong the drug effect was tested on diabetic rats. The results showed that to attain particles suitable for nasal delivery, alginate should be used at its lowest level used in this study (0.6 mg/mL). A low level of chitosan (0.5 mg/mL) was needed when the drug was cation-loaded, while the high chitosan level (1 mg/mL) was more suitable when REP was anion-loaded. The best entrapment efficiency was achieved at a theoretical drug loading of 0.025 mg/mL. Discrete NCs could be rapidly recovered from the spray-dried microparticles. The cytotoxicity and histopathological studies indicated that such formulations were well tolerated. The antihyperglycemic activity of the nasally administered formulae was gradual but was significantly sustained over 24 hours, suggesting NC mucosal uptake. Nasal delivery of such dry powders achieved better glycemic control compared with the conventional oral tablets.

show abstract

“…In addition, since the ZY-beads are heavier and available in very small diameters, the number of beads can be increased to gain the aimed bead-bead interactions needed for efficient size reduction, whereas keeping the bead volume constant. However, successful preparation of liposomes by DC was also demonstrated without any mixing aid present [13,33,34].…”

Section: Mixing Aidsmentioning

confidence: 99%

Dual Centrifugation - A Novel “in-vial” Liposome Processing Technique

Massing¹,

Ingebrigtsen²,

Škalko‐Basnet³

et al. 2017

Liposomes

View full text Add to dashboard Cite

Conventional liposome preparation methods bear many limitations, such as poor entrapment efficiencies for hydrophilic drugs, batch size limitations, and limited options for aseptic manufacturing. Liposome preparation by dual centrifugation (DC) is able to overcome most of these limitations. DC differs from normal centrifugation by an additional rotation of the samples during the centrifugation process. Thus, the direction of the centrifugal forces changes continuously in the sample vials. The consequential powerful sample movements inside the vials result in powerful homogenization of the sample. Since this "in-vial" homogenization is optimal for viscous samples, semisolid "vesicular phospholipid gels" (VPGs) are preferred intermediates in the liposome manufacturing by DC. The DC method easily enables aseptic preparation and is gentler as compared to other methods, such as high-pressure homogenization. The method allows very small samples to be prepared, and VPG batches down to 1-5 mg scale have been prepared successfully. VPGs have several applications; they are attractive as depot formulations, or as stable storage intermediates, and can be easily transferred into conventional liposomal formulations by simple dilution. Here, we aim to present the novel DC-liposome technique; the concept, advantages, and limitations; and provide an overview of the experiences of liposome preparation by DC so far.

show abstract

The effect of polymer coatings on physicochemical properties of spray-dried liposomes for nasal delivery of BSA

Cited by 39 publications

References 64 publications

The nasal delivery of nanoencapsulated statins – an approach for brain delivery

The nasal delivery of nanoencapsulated statins – an approach for brain delivery

Nanocomplexes of an insulinotropic drug: optimization, microparticle formation, and antidiabetic activity in rats

Dual Centrifugation - A Novel “in-vial” Liposome Processing Technique

Contact Info

Product

Resources

About

The effect of polymer coatings on physicochemical properties of spray-dried liposomes for nasal delivery of BSA

Cited by 39 publications

References 64 publications

The nasal delivery of nanoencapsulated statins &ndash; an approach for brain delivery

The nasal delivery of nanoencapsulated statins &ndash; an approach for brain delivery

Nanocomplexes of an insulinotropic drug: optimization, microparticle formation, and antidiabetic activity in rats

Dual Centrifugation - A Novel “in-vial” Liposome Processing Technique

Contact Info

Product

Resources

About

The nasal delivery of nanoencapsulated statins – an approach for brain delivery

The nasal delivery of nanoencapsulated statins – an approach for brain delivery