Sports and HDL-Quality Reflected By Serum Amyloid A and Surfactant Protein B

Sponder, Michael; Kopecky, Chantal; Campean, Ioana-Alexandra; Emich, Michael; Fritzer‐Szekeres, Monika; Litschauer, Brigitte; Graf, Senta; Säemann, Marcus D.; Strametz-Juranek, Jeanette

doi:10.7150/ijms.20388

Cited by 6 publications

(6 citation statements)

References 34 publications

(38 reference statements)

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“…However, in a study in which patients with chronic obstructive pulmonary disease (COPD) were treated with aerobic exercise, increase in ApoA1 concentration was observed [ 13 ]. In a study analyzing the effects of long-term physical activity, HDL-C and ApoA1 levels were increased by 10 and 11%, respectively, but no change was observed in the level of SAA component of HDL-C [ 32 ]. Regular exercise enhances cell recovery and antioxidant effects.…”

Section: Introductionmentioning

confidence: 99%

Can Active Aerobic Exercise Reduce the Risk of Cardiovascular Disease in Prehypertensive Elderly Women by Improving HDL Cholesterol and Inflammatory Markers?

Ahn

Kim

2020

IJERPH

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This study aims to verify the efficacy of exercise programs designed to prevent and treat hypertension-induced cardiovascular disease (CVD) by analyzing the effects of a 6-month active aerobic exercise program, administered to prehypertensive elderly women, on reducing the risk of developing CVD by enhancing their physical fitness level and improving the detailed markers of high-density lipoprotein cholesterol (HDL-C) and inflammatory markers. We assigned the elderly women (≥65 years) recruited into normal blood pressure (120–129/80–84; NBP, n = 18) and high-normal blood pressure (130–139/85–89; HNBP, n = 12) groups according to the European guidelines for the management of arterial hypertension. The exercise program was made up of combined workouts of elastic band resistance exercise and aerobics with dance music. The program took place three times a week for six months, with each session lasting 60 min. We measured pre- and post-intervention body composition, blood pressure, physical fitness level, blood lipids profile, HDL-C, SAA, TNF-α, IL-6, IL-4, IL-15, CRP, and HSP70 and calculated the Framingham risk scores for comparison. A significant post-intervention reduction in the mean systolic blood pressure (SBP) was observed in the HNBP group (p < 0.001), with significant increase in HDL-C (p < 0.01) and significant decrease in serum amyloid A (SAA) concentration (p < 0.01). A significant improvement in physical fitness factors such as physical efficiency index (PEI) was also observed in the HNBP group (p < 0.05). The post-intervention TNF-α, IL-6, and SAA concentrations were more significantly lower in the HNBP than in the NBP group (p < 0.05). Compared to the baseline values, a significant decrease in SAA concentration (p < 0.01) and significant increase in HSP70 concentration (p < 0.001) were observed in the HNBP group. The HNBP group’s 10-year CVD risk was also significantly reduced (p < 0.05). The pre–post differences in SBP and DBP were significantly correlated with those in the anti-inflammatory markers IL-4 and IL-15 (p < 0.01). In conclusion, the 6-month active aerobic exercise program of moderate intensity administered to prehypertensive elderly women (≥65 years) had the effect of reducing the 10-year CVD risk through a substantial reduction in SBP, overall physical fitness improvement, increase in HDL-C, decrease in SAA concentration, and substantial decrease in inflammatory biomarkers. It was also confirmed that an increase in anti-inflammatory markers, which showed a small range of increase with respect to the decrease in blood pressure, may have a major effect.

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Section: Introductionmentioning

confidence: 99%

Can Active Aerobic Exercise Reduce the Risk of Cardiovascular Disease in Prehypertensive Elderly Women by Improving HDL Cholesterol and Inflammatory Markers?

Ahn

Kim

2020

IJERPH

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“…There is growing evidence that low sRAGE levels are a valuable predictor of cardiovascular disease. The investigation of the influence of long-term physical activity on biomarkers for calcification processes [ 8 ], inflammation [ 9 ] or the lipid profile [ 10 , 11 ], inter alia by our group, has already delivered important information; however, the impact of long-term physical activity on sRAGE levels is mostly unknown and available data is conflicting [ 12 , 13 ]. Therefore, it was the aim of the present prospective study to investigate the influence of 8 months of increased physical activity on serum sRAGE levels.…”

Section: Introductionmentioning

confidence: 99%

Long-term physical activity leads to a significant increase in serum sRAGE levels: a sign of decreased AGE-mediated inflammation due to physical activity?

et al. 2018

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There is growing evidence that low levels of the circulating soluble receptor of advanced glycation end products (sRAGE) are a valuable predictor of cardiovascular disease (CVD). The aim of this prospective study was to investigate the influence of long-term physical activity on serum sRAGE levels. 109 subjects were recruited, and 98 completed the study. Participants were asked to perform exercise within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period. sRAGE was measured at baseline and after 2/6/8 months by ELISA. Backwards, multiple linear regression analysis was performed to investigate the association of co-variables age, sex, BMI, and performance at baseline, HbA1c, and lipoprotein a with baseline sRAGE levels. We identified BMI and lipoprotein a as significant predictors for baseline sRAGE levels. Compared to subjects with a performance gain ≤ 4.9% subjects with a gain > 5% showed a significant increase in sRAGE levels up to 22%. sRAGE serum levels correlate negatively with lipoprotein a levels and BMI and long-term physical activity leads to a significant increase in serum sRAGE levels (9–22%), whereby the sRAGE increase is most pronounced in subjects with initially low-performance levels, suggesting that in particular, these subject profit the most from increased physical activity. The sport-mediated increase of sRAGE might be a sign of decreased AGE-mediated inflammation and highlight the protective effect of sports on CVD and other disease which are at least partly mediated by an increased inflammation status.Clinical trials registration NCT02097199.

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“…The beneficial effect of regular physical activity on these surrogate parameters has already been reported before, also by our group. 11,12 Our data show that the self -reported moderate training load does not correlate with the objectively measured performance gain. The discrepancy between the reported training load and performance gain was particularly notable in unathletic individuals.…”

Section: Discussionmentioning

confidence: 64%

The monitoring of performance progress due to long-term physical activity by paper-based training diaries: do training diaries reflect training progress?

Schukro

Emich

Fritzer‐Szekeres

et al. 2019

Polish Archives of Internal Medicine

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INTRODUCTION Training diaries are a common tool for training monitoring; however, their correlation with an effective performance gain is unclear. OBJECTIVES The aim of this prospective study was to investigate whether monitoring of training by paper based training diaries reflects the training progress measured by a bicycle stress test in hobby athletes. PATIENTS AND METHODS Out of 109 hobby athletes who were instructed to work out for 8 months with a calculated training pulse, 98 participants completed the study. Training workload (intensity and time) was recorded with special training diaries. To assess the objective performance gain or change, the bicycle stress test was performed at baseline and at the end of the study. Surrogate parameters associ ated with increased physical activity were also recorded. RESULTS Participants who had a performance gain of at least 3% (mean gain of about 12%) in the bicycle stress test worked out between 547 and 576 min/mo with moderate intensity, and between 14 and 187 min/mo with high intensity. Neither moderate nor high intensity training correlated with the performance gain. CONCLUSIONS Paper based training diaries might serve as an additional tool in the monitoring of train ing progress. However, because of the discrepancy between reported training loads and objectively measured training progress, they are not suitable to replace a standard bicycle stress test for an exact determination of performance gain in hobby athletes. New devices, such as fitness trackers or watches, may present better alternatives in the future.

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Sports and HDL-Quality Reflected By Serum Amyloid A and Surfactant Protein B

Cited by 6 publications

References 34 publications

Can Active Aerobic Exercise Reduce the Risk of Cardiovascular Disease in Prehypertensive Elderly Women by Improving HDL Cholesterol and Inflammatory Markers?

Can Active Aerobic Exercise Reduce the Risk of Cardiovascular Disease in Prehypertensive Elderly Women by Improving HDL Cholesterol and Inflammatory Markers?

Long-term physical activity leads to a significant increase in serum sRAGE levels: a sign of decreased AGE-mediated inflammation due to physical activity?

The monitoring of performance progress due to long-term physical activity by paper-based training diaries: do training diaries reflect training progress?

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