Sport and Children with Immune Thrombocytopenia: Never Give Up

Abstract

In blu la sigla o la definizione ricorrente nel testo, in grigio l'esplicitazione inglese della sigla, in nero la corrispondente spiegazione in italiano AIEOP Associazione Italiana di Ematologia ed Oncologia Pediatrica AIHA Auto-Immune Hemolytic Anemia, anemia emolitica autoimmune ALPS Autoimmune LymphoProliferative Syndrome, Sindrome Linfoproliferativa Autoimmune ANA Anti-nuclear antibody, anticorpi anti nucleo Anti-D Immunoglobuline anti-D ASH American Society of Hematology CFS chronic fatigue syndrome, sindrome da affaticamento cronico DAT direct antiglobulin test, test di Coombs diretto DTP difterite tetano pertosse e.v. endo-vena Fab Fragment Antigen Binding, frammento legante l'antigene FDA Food and Drug Administration, Agenzia per gli Alimenti e i Medicinali GdL Gruppo di Lavoro "Difetti della Coagulazione" HD DXM desametazone ad alte dosi Hp Helicobacter pylori ICIS Intercontinental Cooperative ITP Study Group ITP Immune ThrombocytoPenia , TrombocitoPenia Immune IVIG Immunoglobuline endo-vena IWG International Working Group LES lupus eritematoso sistemico MMF micofenolato mofetile MMR measles mumps rubella, morbillo, parotite, rosolia m-PDN metil-prednisolone mTOR mammalian target of rapamicin MYH9 Myosin heavy chain 9, NTDT Non-transfusion-dependent thalassaemia, talassemia non trasfusione dipendente OPSI overwhelming post splenectomy infection, infezioni gravi post-splenectomia OR Odds Ratio PCR Polymerase Chain Reaction, Reazione a Catena della Polimerasi QoL Quality of life, qualità di vita RC risposta completa RP risposta parziale TCR T-cell receptor, recettore delle cellule T TPO trombopoietina T-reg regulatory T cells, cellule T regolatorie la gestione sarà presa dal curante alla luce dei dati personali del paziente e degli strumenti diagnostici e terapeutici disponibili.

“CHildren with Inherited Platelet disorders Surveillance” (CHIPS) retrospective and prospective observational cohort study by Italian Association of Pediatric Hematology and Oncology (AIEOP)

“…Although further investigations are required to identify the genetic variations responsible for thrombocytopenia, the benefit of distinguishing ITs from acquired forms could become a critical step in improving patient clinical management and follow-up (63)(64)(65)(66). Close monitoring including periodic clinical and laboratory examination could provide clinicians with greater knowledge of forms of thrombocytopenia without genetic identification.…”

Use of Eltrombopag in Children With Chronic Immune Thrombocytopenia (ITP): A Real Life Retrospective Multicenter Experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP)

“…Several individual patient's characteristics such as the bleeding risk that may influence therapeutic choices are unknown. Eltrombopag could have a promising role as second line treatment in ITP to improve HRQoL in pediatric patients (39). Moreover, further prospective studies on decision making, HRQoL, and bleeding symptoms are critically needed.…”

How Physical Activity across the Lifespan Can Reduce the Impact of Bone Ageing: A Literature Review

“…The modifiable factors, such as a balanced diet and exercise, have an important role already in childhood. In particular, regular physical activity has a key role in bone strengthening, not only in healthy children, but also in those suffering from chronic diseases [15][16][17].…”