Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease

Fibromyalgia syndrome is a chronic rheumatic disorder characterized by generalized and widespread musculoskeletal pain. It is associated with several secondary symptoms such as psychological and pain-specific distress, which can directly impact daily functioning and quality of life, like anxiety and depression. The Ganoderma lucidum (GL) mushroom seems to be able to improve fibromyalgia symptoms, including depression and pain. The purpose of the study is to evaluate the effects of GL on happiness, depression, satisfaction with life, and health-related quality of life in women with fibromyalgia. A double-blind, randomized placebo pilot trial was carried out, with one group taking 6 g/day of micro-milled GL carpophores for 6 weeks, during which the second group took a placebo. Our results did not show any statistically significant between-group differences, although a distinct trend of improved levels of happiness and satisfaction with life and reduced depression were evident at the end of treatment compared to the baseline in the GL group. However, due to the limitations of the study protocol, additional studies are necessary to confirm these findings.

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“…Our results confirm the safety of GL. The minor side effects we found were in accordance with those encountered in previous studies [ 25 ].…”

Section: Discussionsupporting

confidence: 92%

Ganoderma lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia

et al. 2020

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“…Beside the well‐documented large‐scale clinical studies on the Ginkgo biloba extract Egb761, 225 only a few randomized, placebo controlled trials have been published 226–233 . The majority of (poly)phenol‐rich plant extracts were tested in open‐label trials 234–237 . Moreover, most studies tested effects of (poly)phenol‐rich extracts over a relative short time on only a small number of participants and the studied plant material was often not well characterized, with some exceptions such as human studies on Egb761R or Cistanche tubulosa glycosides (Memoregain R ) 225,235 .…”

Section: Role Of Biofactors In Neurodegenerative Diseasesmentioning

confidence: 99%

The role of biofactors in the prevention and treatment of age‐related diseases

et al. 2021

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The present demographic changes toward an aging society caused a rise in the number of senior citizens and the incidence and burden of age‐related diseases (such as cardiovascular diseases [CVD], cancer, nonalcoholic fatty liver disease [NAFLD], diabetes mellitus, and dementia), of which nearly half is attributable to the population ≥60 years of age. Deficiencies in individual nutrients have been associated with increased risks for age‐related diseases and high intakes and/or blood concentrations with risk reduction. Nutrition in general and the dietary intake of essential and nonessential biofactors is a major determinant of human health, the risk to develop age‐related diseases, and ultimately of mortality in the older population. These biofactors can be a cost‐effective strategy to prevent or, in some cases, even treat age‐related diseases. Examples reviewed herein include omega‐3 fatty acids and dietary fiber for the prevention of CVD, α‐tocopherol (vitamin E) for the treatment of biopsy‐proven nonalcoholic steatohepatitis, vitamin D for the prevention of neurodegenerative diseases, thiamine and α‐lipoic acid for the treatment of diabetic neuropathy, and the role of folate in cancer epigenetics. This list of potentially helpful biofactors in the prevention and treatment of age‐related diseases, however, is not exhaustive and many more examples exist. Furthermore, since there is currently no generally accepted definition of the term biofactors, we here propose a definition that, when adopted by scientists, will enable a harmonization and consistent use of the term in the scientific literature.

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“…G. lucidium (also known as the "mushroom of immortality" or the "longevity mushroom") and its close relative Ganoderma lingzhi (Sheng H. Wu, Y. Cao, and Y. C. Dai), which has been used in traditional Chinese medicine, contains several bioactive compounds for the alleviation of diseases [62]. Because G. lucidium contains numerous bioactive compounds with alleged health benefits without obvious side effects, it has a reputation as an herbal medicine The bioactive compounds and extracts isolated from different parts of G. lucidum include polysaccharides, β-glucans, lectins, amino acids, lignin, mycin, and vitamins, which have potential antioxidant, anti-inflammatory, and neuroprotective effects [62,63]. Ganodermasides A-D (43)(44)(45)(46), the biologically active compounds obtained from different parts of G. lucidum, increase life span and show antiaging properties [64][65][66].…”

Section: Ganoderma Lucidummentioning

confidence: 99%

A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders

Yadav

Jeewon

et al. 2020

Planta Med

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According to the World Health Organization, neurological and neurodegenerative diseases are highly debilitating and pose the greatest threats to public health. Diseases of the nervous system are caused by a particular pathological process that negatively affects the central and peripheral nervous systems. These diseases also lead to the loss of neuronal cell function, which causes alterations in the nervous system structure, resulting in the degeneration or death of nerve cells throughout the body. This causes problems with movement (ataxia) and mental dysfunction (dementia), both of which are commonly observed symptoms in Alzheimerʼs disease, Parkinsonʼs disease, Huntingtonʼs disease, and multiple sclerosis. Medicinal mushrooms are higher fungi with nutraceutical properties and are low in calories and fat. They are also a rich source of nutrients and bioactive compounds such as carbohydrates, proteins, fibers, and vitamins that have been used in the treatment of many ailments. Medicinal mushrooms such as Pleurotus giganteus, Ganoderma lucidium, and Hericium erinaceus are commonly produced worldwide for use as health supplements and medicine. Medicinal mushrooms and their extracts have a large number of bioactive compounds, such as polysaccharide β-glucan, or polysaccharide-protein complexes, like lectins, lactones, terpenoids, alkaloids, antibiotics, and metal-chelating agents. This review will focus on the role of the medicinal properties of different medicinal mushrooms that contain bioactive compounds with a protective effect against neuronal dysfunction. This information will facilitate the development of drugs against neurodegenerative diseases.

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Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease

Cited by 23 publications

References 25 publications

Ganoderma lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia

Ganoderma lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia

The role of biofactors in the prevention and treatment of age‐related diseases

A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders

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