Sporadic case of eruptive lentiginosis caused by Thr468Met missense mutation in the PTPN11 gene in a Han Chinese patient: first report and systematic literature review

Abstract

COVID-19, regular hand-washing and use of alcoholbased hand sanitizers/gels are part of everyday hygiene guidance for the general public, 2 and therefore, the incidence of hand dermatitis is likely to rise. 3,4 The World Health Organization and the Food and Drugs Administration advises that a minimum alcohol content of 60% is required to inactivate viral particles; however, it is also important to be aware that hand sanitizers/gels may also contain other constituents, including thickeners, humectants (e.g. propylene glycol) and fragrances. 5 We have compiled a table of alcohol-based hand sanitizers/gels and their ingredients, which have recently been independently investigated to confirm their alcohol content or are available in a clinical setting. The ingredients for four sanitizers were not available online. Out of those that listed their ingredients, five out of the seven products include fragrance (Table 1).We would like to highlight to other dermatologists that contact allergy to fragrance and/or other components in hand sanitizer/gels may present acutely with pompholyx, and to consider testing patients with the standard and fragrance series if this is suspected.