Spontaneous tumors in F344/DuCrj rats from 12 control groups of chronic and oncogenicity studies.

Maita, Keizo; Hirano, Masahiro; Harada, Takanori; Mitsumori, Kunitoshi; Yoshida, Atsuko; Takahashi, Koji; Nakashima, Nobuaki; Kitazawa, Toshiaki; Enomoto, Akiko; Inui, Kosei; Shirasu, Yasuhiko

doi:10.2131/jts.12.111

Cited by 39 publications

(11 citation statements)

References 11 publications

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“…The morphological features of the F344 rat MM are similar to those of human or asbestos-induced murine MM, but they are more uniform and, typically, show a simple papillary growth of epithelial-type cells [10,23,24,31]. Previously, we established cell lines from rat spontaneous mesothelioma [18].…”

Section: Introductionmentioning

confidence: 94%

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Transforming growth factor β production by spontaneous malignant mesothelioma cell lines derived from Fisher 344 rats

Kuwahara¹,

Takeda²,

Takeuchi³

et al. 2001

Virchows Arch

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We investigated whether transforming growth factor beta (TGF-beta) is involved in the growth of malignant mesothelioma (MM) cells in culture. TGF-beta production was examined in two mesothelioma cell lines (MeET-4 and -6) that were established from rat spontaneous MM in our laboratory. TGF-beta bioactivity in conditioned medium of these cell lines was analyzed using a CCL64 mink lung epithelial cell growth inhibition assay and found to be 30-70 times higher than that of normal rat mesothelial cells (MCs). The MM cell lines also showed considerably higher levels of TGF-beta mRNA expression when compared with MCs. The bioactivity and mRNA expression level were greater in MeET-4 than MeET-6. When MeET-4 was treated with antisense TGF-beta1 oligonucleotide (ODN), a significant decrease in both anchorage-dependent and -independent growth was observed. Treatment with exogenous TGF-beta resulted in no effects on the growth pattern of the MM cell lines, while proliferation of the MCs was slightly induced. It is considered that TGF-beta appears to be produced by rat spontaneous MM cells through an autocrine mechanism and could modulate the malignant growth of the tumor cells.

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Section: Introductionmentioning

confidence: 94%

“…In Fisher 344 (F344) rats, abdominal MM is a rather rare spontaneous tumor with an aged male predominance [11,12,23,24]. The morphological features of the F344 rat MM are similar to those of human or asbestos-induced murine MM, but they are more uniform and, typically, show a simple papillary growth of epithelial-type cells [10,23,24,31].…”

Section: Introductionmentioning

confidence: 99%

Transforming growth factor β production by spontaneous malignant mesothelioma cell lines derived from Fisher 344 rats

Kuwahara¹,

Takeda²,

Takeuchi³

et al. 2001

Virchows Arch

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“…It was reported that C-cell tumor developed with a high incidence in Wistar and F344 rats but that it developed with a low incidence in SD rats 8 . Meanwhile, the incidence of C-cell tumor in female Harlan SD rats (25.43%) in the National Toxicology Program (NTP) 9 was far higher than that in the historical control data in female Charles River SD rats (7.21%) 10 and the above data from F344 rats 4 , 5 , 6 , 7 . Therefore, it seems that there are differences in tumor incidence between the substrains of suppliers.…”

Section: Resultsmentioning

confidence: 81%

“…In the historical control data that were published between 1987 and 2011, the incidences of C-cell adenoma in the thyroid of F344 rats were 9.2 to 15.42% in males and 6.7 to 12.14% in females 4 , 5 , 6 , 7 . The incidence in 2005–2009 in the present survey was higher than those data.…”

Section: Resultsmentioning

confidence: 99%

Transition of Historical Control Data for High Incidence Tumors in F344 Rats

et al. 2013

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Historical control data of tumor incidence were collected from the control groups (215 animals of each sex) in four recent carcinogenicity studies that were started between 2005 to 2009 (terminally sacrificed between 2007 and 2011) at BoZo Research Center Inc. (Gotemba, Shizuoka, Japan) using Fischer 344 rats (F344/DuCrlCrlj). These data were compared to the previous historical control data (from 1990 to 2004, previously reported) in the same facility. In the results, the incidence of C-cell adenoma in the thyroid tended to increase in both sexes in recent years (30.8% for males and 24.4% for females in 2005-2009) as compared with the previous data (17.4% and 20.1% for males and 11.5% and 11.8% for females in 1990–1999 and 2000–2004, respectively). In addition, the incidences of pancreatic islet cell adenoma in males and uterine adenocarcinoma tended to increase from around 2000 and remained high in recent years (incidences of islet cell adenoma in males of 10.5%, 17.1% and 20.5% in 1990–1999, 2000–2004 and 2005–2009; incidences of uterine adenocarcinoma of 3.3%, 12.0% and 13.5% in 1990–1999, 2000–2004 and 2005–2009, respectively). There was no apparent difference in the incidence of other tumors.

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“…Although most of the spontaneous pituitary tumors in rats are thought to be benign, malignant tumors are recognized with a low incidence (6,7,10,15,17,18,20). In rats, there is a dearth of information dealing with xenobiotic-induced pituitary carcinomas, including estrogen-induced tumors.…”

Section: Introductionmentioning

confidence: 99%

Invasive Pituitary Tumors in Female F344 Rats Induced by Estradiol Dipropionate

Satoh

Kajimura

Chen³

et al. 1997

Toxicol Pathol

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To clarify the histopathological progression of invasive tumors in the pituitary pars distalis due to estrogen, female Fischer 344 (F344) rats were treated subcutaneously with 5 mg/animal of estradiol dipropionate (ED) once every 2 wk for 13 wk. The animals were killed serially at 2-wk intervals during the investigation. The pituitaries with surrounding tissues were examined light microscopically. At week 7, pituitary cells showed proliferation and atypia with formation of blood-filled spaces. Lesions with these characteristics were diagnosed as adenomas. At week 9 or later, neoplastic cells exhibited extensive proliferation and infiltration into the surrounding tissues, suggesting development of carcinoma. Both proliferating cell nuclear antigen (PCNA) and 5-bromo-2'-deoxyuridine (BrdU) labeling index, markers of cell proliferation, were significantly increased in animals with adenoma or carcinoma. To detect sequential changes in pituitary weight, its signal intensity was periodically monitored in identical rats by using magnetic resonance (MR)

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Spontaneous tumors in F344/DuCrj rats from 12 control groups of chronic and oncogenicity studies.

Cited by 39 publications

References 11 publications

Transforming growth factor β production by spontaneous malignant mesothelioma cell lines derived from Fisher 344 rats

Transforming growth factor β production by spontaneous malignant mesothelioma cell lines derived from Fisher 344 rats

Transition of Historical Control Data for High Incidence Tumors in F344 Rats

Invasive Pituitary Tumors in Female F344 Rats Induced by Estradiol Dipropionate

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