Spontaneous thyroiditis in laboratory rats

Hajdu, A.; Róna, G

doi:10.1007/bf01897529

Cited by 20 publications

(5 citation statements)

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“…As well, marked lymphopenia and monocytopenia were seen at baseline which might contribute to differences in innate and adaptive immunity in Fischer compared with other rat strains. 29,30 Hypoxia also led to thrombocytopenia in both rat strains, although this was more profound in Fischer rats, which is consistent with a recent report describing severe thrombocytopenia in Fischer SuHx rats. 31 While the WGS did not reveal any unique variants within the coding regions of the AK1 gene in Fischer rats, there was a mutation located 1790 base pairs upstream.…”

Section: Discussionsupporting

confidence: 91%

Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics

et al. 2022

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BACKGROUND: We explored the mechanism of maladaptive right ventricular (RV) remodeling in Fischer compared with Sprague-Dawley (SD) rats exposed to pressure overload. METHODS: Pulmonary hypertension was induced by injection of the VEGFR antagonist, SU5416, followed by a 3-week exposure to hypoxia (Sugen chronic hypoxia). In vivo oxidative metabolism was assessed by RV/left ventricle ratio of [ 11 C]acetate positron emission tomography clearance (kmono). Unbiased, global transcriptional and proteomic profiling was performed in Fischer and SD rats at baseline and after Sugen chronic hypoxia. RESULTS: All Fischer rats succumbed to RV failure by 5 weeks, whereas SD rats showed preserved RV function and 88% survival beyond 9 weeks ( P <0.0001). Fischer rats exhibited increased oxidative metabolism at 4 weeks ( P <0.05) and impaired RV efficiency compared with SD (work metabolic index: 52±10 versus 91±27 mmHg·mL/cm 2 , respectively; P <0.05), but no differences in mitochondrial complex activity. AK1 (adenylate kinase 1) was among the top 10 differentially expressed genes between Fischer and SD rats, with markedly lower RV expression in Fischer rats (FC: 3.36, P <0.05), confirmed by proteomic analysis and validated by Western blotting (>10-fold reduction, P <0.001). While whole-genome sequencing failed to reveal any coding region mutations in Fischer rats, there was a unique variant in a highly conserved upstream flanking region likely involved in the regulation of AK1 expression. CONCLUSIONS: Therefore, Fischer rats exhibit profound AK1 deficiency and inefficient cardiac energetics likely related to reduced adenosine triphosphate shuttling from the mitochondria to the contractile fibers. This represents a novel mechanism for RV failure in response to chronic increases in afterload.

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Section: Discussionsupporting

confidence: 91%

Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics

et al. 2022

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“…Cole et al [1968] described the disease in obese-strain chickens. Tucker [ 19621 reported the entity in a group of laboratory beagle dogs, and Haydu and Rona [1969] described the disease in laboratory rats. The original description of this thyroid gland disorder in people, with its distinctive histologic appearance, was presented by Hashimoto [1912].…”

Section: Introductionmentioning

confidence: 99%

The Familial Occurrence of Lymphocytic Thyroiditis in Borzoi dogs

Conaway

Padgett

et al. 1985

Am. J. Med. Genet.

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A group of related borzoi dogs were studied over a 6-year period to ascertain the cause of primary hypothyroidism. Four generations of dogs were analyzed. Two littermates with lymphocytic thyroiditis were mated and the 10 offspring were all diagnosed, on the basis of thyroid biopsy evaluation, as having lymphocytic thyroiditis by age 2.5 years. A wide range of thyroid gland lesions was demonstrated in this litter of dogs. This report documents the occurrence of lymphocytic thyroiditis in three successive generations of an inbred group of borzoi dogs. An autosomal recessive mode of inheritance for the trait in this group of dogs is proposed.

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“…However, spontaneously occurring LT in experimental animals is rare and has been reported only in Beagle dog (Tucher et al, 1962), in obese strain chicken (Coie et al, 1968), in monkey (Biggazi et al, 1975) and in Buffalo strain (BUF) rat (Hajdu et al, 1969). The BB/W rat may thus be valuable in the elucidation of the basic pathogenesis (Colle et al, 1981), prevention (Like et al, 1979;Naji, 1981;Rossini et al, 1984) and treatment of auto-immune thyroidal disease in man.…”

mentioning

confidence: 99%