Spontaneous Supracondylar Femoral Fracture in an HIV Patient in Lotus Position

Neto, Lauro F.S. Pinto; Eis, Sérgio Ragi; Miranda, Angélica Espinosa

doi:10.1016/j.jocd.2010.11.002

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Another factor which could result in ill effects of yoga practice is an existing condition which may predispose the practitioner to deformity or illness (Cramer et al, 2013). A case study reported that sitting in the lotus pose during a meditation session resulted in a spontaneous supracondylar femoral fracture in a 58 year old Buddhist monk who was human immunodeficiency virus (HIV) positive (Pinto Neto et al, 2011). Patients with the HIV virus have compromised bone density due to the use of antiretroviral therapies which are associated with bone loss and fractures (Puthanakit et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Yoga as a Holistic Treatment for Chronic Illnesses: Minimizing Adverse Events and Safety Concerns

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Yoga as a Holistic Treatment for Chronic Illnesses: Minimizing Adverse Events and Safety Concerns

et al. 2019

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“…HIV-infected patients show bone loss and osteopenia/osteoporosis during the course of the disease [17–22]. The mechanisms underlying this degenerative process are largely unclear, and it has yet to be determined how bone dysfunction is linked to HIV- 1-mediated direct and/or indirect effects on osteoblasts/osteoclasts and their cross-talk regulation.…”

Section: Introductionmentioning

confidence: 99%

Hemin activation of innate cellular response blocks human immunodeficiency virus type-1-induced osteoclastogenesis

Takeda

Adhikari

Yamada

et al. 2015

Biochemical and Biophysical Research Communications

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The normal skeletal developmental and homeostatic process termed osteoclastogenesis is exacerbated in numerous pathological conditions and causes excess bone loss. In cancer and HIV-1-infected patients, this disruption of homeostasis results in osteopenia and eventual osteoporesis. Counteracting the factors responsible for these metabolic disorders remains a challenge for preventing or minimizing this comorbidity associated with these diseases. In this report, we demonstrate that a hemin-induced host protection mechanism not only suppresses HIV-1 associated osteoclastogenesis, but it also exhibits anti-osteoclastogenic activity for non-infected cells. Since the mode of action of hemin is both physiological and pharmacological through induction of heme oxygenase-1 (HO-1), an endogenous host protective response to an FDA-licensed therapeutic used to treat another disease, our study suggests an approach to developing novel, safe and effective therapeutic strategies for treating bone disorders, because hemin administration in humans has previously met required FDA safety standards.

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Spontaneous Supracondylar Femoral Fracture in an HIV Patient in Lotus Position

Cited by 2 publications

References 10 publications

Yoga as a Holistic Treatment for Chronic Illnesses: Minimizing Adverse Events and Safety Concerns

Yoga as a Holistic Treatment for Chronic Illnesses: Minimizing Adverse Events and Safety Concerns

Hemin activation of innate cellular response blocks human immunodeficiency virus type-1-induced osteoclastogenesis

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