Spontaneous Spinal Epidural Hematoma with Associated Platelet Dysfunction from Excessive Garlic Ingestion: A Case Report

Abstract

The authors report a case of spontaneous spinal epidural hematoma causing paraplegia secondary to a qualitative platelet disorder from excessive garlic ingestion. The case also demonstrates satisfactory recovery from thoracic spinal epidural hematoma in a nonagenarian. Recovery from severe spinal cord compression can occur even in the very elderly.

Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation

“…18 Two case reports suggest a possible increase in the risk of bleeding with garlic use. 20,21 Prior trials of St. John's wort present conflicting and confusing evidence, but the herb is likely effective for the treatment of mild-to-moderate depression. 22,23 Two recent studies found it to be ineffective for patients with severe depression.…”

Herbal remedies affecting coagulation: A review

“…It is of great importance to validate in vitro results in animal studies, as there is always the chance that absorption, metabolism, or excretion may lead to significant changes in the herbals effect on coagulation. Many phytochemicals, such as coumarins, thiosulfinates, adenosine, paraffinic polysulfides and ajoene) Srivastava, 1986;Rose et al, 1990;Basila & Yuan, 2005;Beckert et al, 2007 (Continued) polyphenolis, saponins, and salicylates, were elucidated as potent inhibitors, but the concentrations of these may be of such insignificant levels that they pose no threat. Also, depending on manufacturing and processing procedure concentrations and activity of extracts might differ (Chukwumah et al, 2007).…”

Safety, Efficacy, Regulations and Bioethics in Herbal Medicines Research and Practice

“…However, it is associated with gastro intestinal discomfort and bad garlic breath [34]. It has also been associated with increased danger of bleeding after use of garlic [36,37].…”