Herbal remedies affecting coagulation: A review

Cordier, Werner; Steenkamp, Vanessa

doi:10.3109/13880209.2011.611145

Cited by 68 publications

(37 citation statements)

References 77 publications

(41 reference statements)

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“…Conversely, many nonprescription medications and herbal supplements may pose potential risk of bleeding or drug interaction. 19,20 Over-the-counter medications and supplements should be stopped before surgery, unless there is specific reason to continue them (eg, aspirin in certain patients with cardiac conditions). The exact timing will depend on the medication or supplement involved.…”

Section: Medicationsmentioning

confidence: 99%

The Pediatrician’s Role in the Evaluation and Preparation of Pediatric Patients Undergoing Anesthesia

Goldschneider¹,

Cravero²,

Anderson³

et al. 2014

Pediatrics

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Pediatricians play a key role in helping prepare patients and families for anesthesia and surgery. The questions to be answered by the pediatrician fall into 2 categories. The first involves preparation: is the patient in optimal medical condition for surgery, and are the patient and family emotionally and cognitively ready for surgery? The second category concerns logistics: what communication and organizational needs are necessary to enable safe passage through the perioperative process? This revised statement updates the recommendations for the pediatrician' s role in the preoperative preparation of patients. Pediatrics 2014;134:634-641 INTRODUCTIONPrimary care providers, including pediatricians, are frequently called on to evaluate and psychologically prepare patients and families before a child undergoes a procedure requiring anesthesia or sedation. This policy statement identifies that primary care provider' s preoperative goals of care are as follows: to clearly define the child' s medical issue; to delineate the physiologic effects and limitations imposed by each condition; and to optimize the management of any comorbid conditions. Furthermore, the policy recommends that pediatricians facilitate essential communication about the historical, physical, and laboratory findings in children with unusual or complex medical histories with the anesthesiologist and/or surgeon to ensure safe perioperative care.The objectives of the present statement were twofold:1. to describe to pediatricians the issues of concern to anesthesiologists and surgeons to improve the effectiveness of medical consultations in preparing pediatric patients and families for the perioperative period; and 2. to present information that will encourage and facilitate communication among surgeons, anesthesiologists, medical subspecialists, pediatricians, and other primary care providers.

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Section: Medicationsmentioning

confidence: 99%

The Pediatrician’s Role in the Evaluation and Preparation of Pediatric Patients Undergoing Anesthesia

Goldschneider¹,

Cravero²,

Anderson³

et al. 2014

Pediatrics

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“…1 Accordingly, the screening of platelet and the coagulation activation may be a useful tool to explore antithrombotic agents. 7,9 In this study, anticoagulant assays showed that AME could significantly prolong coagulation parameters, PT, APTT and TT, indicating its ability to inhibit both extrinsic, intrinsic, and the common pathways of the coagulation cascades. Moreover, our results revealed that the active compounds responsible for these activities may be the flavonoid compounds, which showed stronger activities than coumarins for all anticoagulant assays.…”

Section: Discussionmentioning

confidence: 95%

“…An exploratory trial toward identifying new anticoagulants and antiplatelet from medicinal plants is worthwhile. 9 The perennial herb Angelica shikokiana (Apiaceae) is a Japanese medicinal plant known as Inutouki or Yamaninjin and is used as a substitute drug for ginseng roots. 10 Traditionally, soluble preparations from stems and leaves are used for several complications of cardiovascular diseases such as hyperlipidemia, diabetes, atherosclerosis, and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Antiplatelet and Anticoagulant Activities ofAngelica shikokianaExtract and Its Isolated Compounds

Mira

Alkhiary

Shimizu

2016

Clin Appl Thromb Hemost

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Angelica shikokiana is a Japanese medicinal plant that is used traditionally in several ailments of cardiovascular diseases. However, there is no report regarding its anticoagulant or antiplatelet activities. So this study was designed to screen for such activities (anticoagulant by prothrombin time [PT], activated partial thromboplastin time, and thrombin time assays and antiplatelet activities against adenosine 5'-diphosphate [ADP] and arachidonic acid-induced platelet aggregations) for the methanol extract of the aerial part (Angelica methanol extract [AME]), its isolated coumarins, flavonoids, and flavonoid metabolites. The AME had potent anticoagulant and antiplatelet activities, and the flavonoid compounds were evidenced to be responsible for such activities. Among coumarins compounds, hyuganin C showed significant prolongation of only PT, while other coumarins were inactive. Similarly, hyuganin C and bergapten were the only active coumarins against ADP-induced platelet aggregation. Compared to the parent compounds, colonic metabolites of the flavonoids had similar anticoagulant and antiplatelet activities, while glucuronides showed sharp decreases in all studied activities. This is the first report showing that the medicinal plant A shikokiana has potent antiplatelet and anticoagulant activities.

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“…Special attention to prescription (oral anticoagulant) and nonprescription medication is important. A recent comprehensive review by Cordier and Steenkamp [9] identified 65 herbal medications with effects on platelet function and the coagulation cascade. These substances should be discontinued for at least 1 week prior to FESS.…”

Section: Preoperative Considerationsmentioning

confidence: 99%