Spontaneous shedding and antibody induced modulation of histocompatibility antigens on murine lymphomata: Correlation with metastatic capacity

Abstract

Summary.-The lability of cell surface histocompatibility antigens of 2 murine lymphomata was examined. These 2 tumours differ greatly in their capacity to metastasize in syngeneic hosts. Cells of the metastatic lymphoma released histocompatibility antigens in vivo and in vitro at a greater rate than cells of the nonmetastasizing lymphoma. Antigen/antibody complexes formed by the addition of allo-antiserum to intact cells disappeared more rapidly from the surface of cells of the metastatic line. We propose that the instability of surface antigens may be an integral feature of malignant cells and that there may be a quantitative relationship between the lability of membrane components and the capacity of the tumour to metastasize.

Triple Role of T and Tn Antigens in Cancer: as Universal, Clonal Carcinoma Markers, in Cancer Cell Adhesion, and as Autoimmunogens

“…The highly invasive and meta static ESb subline of a murine T lymphoma [69] adheres to syngeneic hepatocytes and lung tissue in vitro, whereas the parent Eb lymphoma, which has low invasive and met astatic potential, does not [70]. We found that the ESb T lymphoma cells had a stronger expression of Tn and T on their outer plasma membranes than did Eb [50,65].…”

Specific Role of T and Tn Tumor‐associated Antigens in Adhesion between a Human Breast Carcinoma Cell Line and a Normal Human Breast Epithelial Cell Line

“…These pan-CA auto-antigens [8][9][10] play a profound role in cancer pathogenesis. 11) Specific adhesion between invasive, metastatic murine Esb T-lymphoma cells and syngeneic hepatocytes has been demonstrated 12,13) ; direct molecular binding of the Esb cells, which were later confirmed to strongly express T and Tn antigens on their cell surfaces, 14) to the corresponding ligands was the first step after the recognition of hepatocyte ligands. Moreover, cultured breast CA DU4475 cells and desialylated, isologous erythrocytes [TRBC] bound specifically to the Gal/GalNAc receptors of rat Kupffer cells and of hepatocytes.…”

Collagen production by macrophages in tumour encapsulation and dormancy

“…Tumour factors such as phenotypic diversity (Weinhold et al, 1979), tumour invasive factors (e.g. collagenase) (Woolley, 1982;Pauli et al, 1983), antigen shedding (Davey et al, 1976), and immunosuppressive factors (Eccles & Alexander, 1975), may be involved when growth resumes.…”