Collagen production by macrophages in tumour encapsulation and dormancy

Vaage, Jan; Harlos, J. P.

doi:10.1038/bjc.1991.169

Cited by 28 publications

(16 citation statements)

References 23 publications

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“…The increase in soluble collagen indicates new collagen synthesis which in turn could have contributed to a higher cellematrix interaction and cellecell contact thus leading to the loss of cell death and (Pullan et al, 1996). It has been reported earlier that newly synthesized collagens favor the growth of mammary tumor cells Wicha et al, 1981;Bano et al, 1983), while the maturation of collagen by cross-link formation encased the tumors and prevents proliferation of tumor cells (Kimoto et al, 1988;Vaage and Harlos, 1991). The significance of collagen in tumor development is further emphasized by the fact that administration of cis-hydroxyproline, the collagen synthesis inhibitor, blocked the development of DMBA-and MNU-induced mammary tumors Wicha et al, 1981).…”

Section: Discussionmentioning

confidence: 95%

Influence of estradiol on mammary tumor collagen solubility in DMBA‐induced rat mammary tumors

Lakshmanaswamy

Balasubramanian

Arunakaran

et al. 2006

Cell Biology International

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Estradiol plays a vital role in the growth and development of mammary glands. It is a potent stimulator of metabolic processes in normal and carcinoma breast. A critical factor in determining mammary glandular morphology is the stroma. Collagen is a predominant component of the extracellular matrix and cell-collagen interactions are essential carcinogenesis. The present investigation explored the influence of estradiol on collagen solubility and metabolism in mammary tumors during tumor progression and regression. A single injection of 20 mg of 9,10-dimethyl-1,2-benzanthracene was given to rats at 7 weeks of age. With the appearance of the first palpable mammary tumor, the rats were treated with 0.5 microg estradiol or 50 microg tamoxifen daily for 30 days. The rats were sacrificed 24 h after 30 days of treatment. Estradiol appears to stimulate the synthesis of new collagens and thus contributes to the enlargement of the mammary tumors. This might have created a potential microenvironment by increasing the synthesis of suitable matrix that sustains the growth of the mammary tumors. In short, the present findings emphasize a definite mediatory role for collagen in estradiol promoted mammary tumor growth.

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Section: Discussionmentioning

confidence: 95%

Influence of estradiol on mammary tumor collagen solubility in DMBA‐induced rat mammary tumors

Lakshmanaswamy

Balasubramanian

Arunakaran

et al. 2006

Cell Biology International

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“…This included extensive fibrosis and also the presence of a collagen capsule surrounding tumour cells. The capsule appears to be laid down by infiltrating macrophages (Vaage and Harlos, 1991). The vascular proliferation may have been stimulated by angiogenic growth factors secreted by the infiltrating macrophages (Leek et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Early detection of tumour immune-rejection using magnetic resonance imaging

et al. 2003

Br J Cancer

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Dynamic contrast agent-enhanced magnetic resonance imaging measurements of the perfusion of an immunogenic murine tumour showed that immune rejection was preceded by an increase in the apparent vascular volume of the tumour. This increase in vascularity, which has been observed previously in other tumours undergoing immune rejection, was confirmed by histological analysis of tumour sections obtained postmortem. Magnetic resonance imaging measurements similar to this could be used in the clinic to monitor the early responses of tumours to immunotherapy, before there is any change in tumour growth rate or volume.

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“…These contrasting results are hard to evaluate because of the difficulty of performing experimental tests. One of the few such tests is in the work of Vaage and Harlos [16], who showed that production of collagen by macrophages is responsible for the encapsulation of tumor implants in mice; however, this may be different from the mechanisms involved for naturally arising tumors.…”

Section: Fig 1 the Appearance Of An Encapsulated Hepatocellular Carmentioning

confidence: 99%

“…This explains the wide discrepancies between studies attempting to correlate tumor size and capsule incidence or thickness [12], [17], [13], [6] and argues against the conventional intuition that these should be correlated if the capsule forms without matrix production. The key experimental test of the model would be to study the correlation between capsule density and some measure of the parameter k. This is not possible using pathology data alone but may be possible for animal studies of the encapsulation of tumor implants, of the type performed by Vaage and Harlos [16]. This would involve culturing cells from the implant in vitro and comparing the k value of the cultured cells.…”

Section: Model Extensionmentioning

confidence: 99%

Traveling Wave Solutions of a Mathematical Model for Tumor Encapsulation

Sherratt¹

2000

SIAM J. Appl. Math.

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Abstract. The formation of a capsule of dense, fibrous extracellular matrix around a solid tumor is a key prognostic indicator in a wide range of cancers. However, the cellular mechanisms underlying capsule formation remain unclear. One hypothesized mechanism is the "expansive growth hypothesis," which suggests that a capsule may form by the rearrangement of existing extracellular matrix, without new matrix production. A mathematical model was recently proposed to study the implications of this hypothesis [Perumpanani, Sherratt, and Norbury, Nonlinearity, 10 (1997), pp. 1599-1614. The model consists of conservation equations for tumor cells and extracellular matrix and exhibits traveling wave solutions in which a pulse of extracellular matrix, corresponding to a capsule, moves in parallel with the advancing front of the tumor. In this paper the author presents a detailed study of traveling wave behavior in the model, deriving conditions for the existence of traveling waves and their key properties. Numerical methods for solving the model equations are presented, and numerical simulations suggest that the traveling waves are stable and are the biologically relevant solution form for the model. The analytical results are extended to an improved model, which includes a saturation in the extent of matrix rearrangement per cell. Finally, the author discusses the biological implications of the model results.

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Collagen production by macrophages in tumour encapsulation and dormancy

Cited by 28 publications

References 23 publications

Influence of estradiol on mammary tumor collagen solubility in DMBA‐induced rat mammary tumors

Influence of estradiol on mammary tumor collagen solubility in DMBA‐induced rat mammary tumors

Early detection of tumour immune-rejection using magnetic resonance imaging

Traveling Wave Solutions of a Mathematical Model for Tumor Encapsulation

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