Spontaneous rupture of malarial spleen: two case reports and review of literature

Yağmur, Yusuf; Kara, İsmail Hamdi; Aldemir, Mustafa; Büyükbayram, Hüseyin; Taçyıldız, İbrahim; Keleş, Celalettin

doi:10.1186/cc713

Cited by 69 publications

(17 citation statements)

References 14 publications

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“…Also, the reference data for waist circumference refer to UK children and it is unclear whether this can be applied to Cameroonian children. In addition, care should be taken in the interpretation of waist circumference findings because studies have shown that an enlarged spleen (which can be asymptomatic) is common in malaria endemic areas [ 33 ]. This study did not carry out any malaria diagnosis; therefore, there is the possibility that some WC readings may have been falsified in children who may have an enlarged spleen as a result of malaria.…”

Section: Discussionmentioning

confidence: 99%

Height-obesity relationship in school children in Sub-Saharan Africa: results of a cross-sectional study in Cameroon

et al. 2015

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BackgroundIn developed nations, taller children exhibit a greater propensity to overweight/obesity. This study investigates whether this height-adiposity relationship holds true for Cameroon children using two parameters of adiposity including body mass index (BMI) and waist circumference (WC).MethodsIn 557 children (287 boys and 270 girls, mean age 9.0 ± 1.8 years) from the North West Region of Cameroon height, weight and WC were measured and BMI calculated. Variables were converted to standard deviation scores (SDS). Participants were divided into quartiles of height SDS, then mean of age and sex-standardized body fat parameters compared across quartiles. The frequency of excess adiposity was calculated within each quartile. Correlation and regression analysis were used to assess height-adiposity relationships.ResultsMultiple comparisons indicated a significant increase in mean BMI (−0.08 to 0.65) and WC (−0.11 to 0.87) SDSs with increasing quartiles of height SDS. Frequency of overweight/obesity and abdominal overweight/obesity was highest among children with highest height SDS (30.2 – 33.1%) and lowest in their shortest peers (0.7 – 5.0%). There was a linear relationship between height SDS and BMI SDS (R2 = 0.087, p < 0.001); height SDS and WC SDS (R2 = 0.356, p < 0.001) among both boys and girls.ConclusionsThis study shows that in Cameroon just as in developed economies a higher height SDS is associated with a higher frequency of overweight/obesity. This is independent of the parameter used to evaluate overweight/obesity (BMI SDS or WC SDS).

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Section: Discussionmentioning

confidence: 99%

Height-obesity relationship in school children in Sub-Saharan Africa: results of a cross-sectional study in Cameroon

et al. 2015

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“…Close monitoring is indispensable, especially for subcapsular hemorrhage. Medical treatments [9], embolization [6], and splenectomy [10] are considered for the treatment of splenic rupture. The treatment should be determined carefully considering the vital signs and bleeding tendency.…”

Section: Discussionmentioning

confidence: 99%

Subcapsular Splenic Hemorrhage in Vivax Malaria

Chung²,

Durey

et al. 2019

Korean J Parasitol

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In malaria, splenic rupture is a serious complication potentially leading to death. Subcapsular hemorrhage of spleen is thought to be an impending sign of splenic rupture; however, the characteristics of subcapsular hemorrhage are not well known. We report 3 cases of subcapsular hemorrhage of the spleen in vivax malaria, with varying degrees of severity. Case 1 showed subcapsular hemorrhage without splenic rupture, was treated by antimalarial drug without any procedure. The healing process of the patient's spleen was monitored through 6 computed tomography follow-up examinations, over 118 days. Case 2 presented subcapsular hemorrhage with splenic rupture, treated only with an antimalarial drug. Case 3 showed subcapsular hemorrhage with splenic rupture and hypotension, treated using splenic artery embolization. They all recovered from subcapsular hemorrhage without any other complications. These 3 cases reveal the process of subcapsular hemorrhage leading to rupture and a potentially fatal outcome. The treatment plan of subcapsular hemorrhage should be determined carefully considering the vital signs, changes in hemoglobin, and bleeding tendency.

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“…These are physical activity-related increase in the intraabdominal pressure and compression applied by vigorously contracting abdominal muscles, increase in the intrasplenic pressure resulting from the cellular congestion, and promoted endothelial fragility by such events as thromboses and infarctions within the spleen. [ 17 18 ]…”

Section: Discussionmentioning

confidence: 99%

Spontaneous splenic rupture due to uremic coagulopathy and mortal sepsis after splenectomy

Gazel¹,

Açikgöz²,

Kasap³

et al. 2015

Int J Crit Illn Inj Sci

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Nontraumatic spontaneous splenic rupture (NSSR) has been encountered much more rarely compared with the traumatic splenic rupture. Although NSSR generally emerges in dialysis patients on account of such causes as the use of heparin during hemodialysis, uremic coagulopathy, infections, and secondary amyloidosis. Herein, we aimed to present a case of spontaneous splenic rupture which had developed soon after the inclusion of the case suffering from end-stage renal disease in routine hemodialysis program in the absence of any trauma or other prespecified risk factors for splenic rupture. A 55-year-old male patient was admitted to our hospital to have the ureteral double J stent removed. The operation was completed without any complication. Complaining an abdominal pain more prominent in the left upper abdominal quadrant in the first postoperative day, the patient underwent a through physical examination which disclosed abdominal distension, widespread tenderness, and rebound and defense positivity. The abdominal tomography depicted 122 × 114 × 95 mm lesion compatible with a hematoma. On the basis of these findings, an emergency exploratory operation was decided to be performed. Following clearance of the retroperitoneal hematoma, splenectomy was implemented. Experiencing progressive deterioration in his clinical status despite antibiotherapy, the patient unfortunately died of sepsis with multiorgan failure on the 25th postoperative day. In conclusion, NSSR is such an entity that may be missed out, can pursue variable clinical courses, and requires emergency therapy upon definitive diagnosis. The possibility of spontaneous bleedings should be kept in mind in any case with the history of hyperuricemia even in the absence of overt trauma, no matter if they are included in routine hemodialysis or not.

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Spontaneous rupture of malarial spleen: two case reports and review of literature

Cited by 69 publications

References 14 publications

Height-obesity relationship in school children in Sub-Saharan Africa: results of a cross-sectional study in Cameroon

Height-obesity relationship in school children in Sub-Saharan Africa: results of a cross-sectional study in Cameroon

Subcapsular Splenic Hemorrhage in Vivax Malaria

Spontaneous splenic rupture due to uremic coagulopathy and mortal sepsis after splenectomy

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