“…Adverse development of the media and alterations of the vasa vasorum, severe atherosclerosis, and blood flow shear stress may be pathogeny. Malignant hypertension, fibromuscular dysplasia (15), strenuous exercise (including sexual) (17), taking medication (18,19), Marfan syndrome (20), and Ehlers-Danlos syndromes ( 4) are all possible risk factors. In our two case studies, we found that both of the patients had a long history of smoking, which was similar to the reports by other researchers (6,11,21).…”