Spontaneous remission of T lymphoblastic lymphoma

Ceesay, M. Mansour; Vadher, Bipin; Tinwell, Brendan; Goderya, Rashida; Sawicka, Ewa

doi:10.1136/jcp.2008.056697

Cited by 9 publications

(7 citation statements)

References 5 publications

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“…This translocation results in the fusion of two genes, AMLl (RUNX1) on chromosome 21 and ETO (RUNX1T1) on chromosome 8, with the formation of a chimeric gene AMLl/ETO on the derivative 8[der (8)] chromosome (17), which carries a relatively favorable prognosis (18). Research on cytogenetic abnormalities and gene mutations will identify patients with no evidence of infection who require no blood transfusions (19).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Remission in Patients with Acute Myeloid Leukemia with t(8;21) or Cutaneous Myeloid Sarcoma: Two Case Reports and a Review of the Literature

et al. 2013

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Spontaneous remission (SR) in patients with acute myeloid leukemia (AML) is rare. We herein present two such cases. The first case was of AML-M2 accompanied by a bone marrow cytogenetic analysis revealing 46, XY, t(8;21)(q22,q22). The second case was of isolated cutaneous myeloid sarcoma (MS) that progressed to AML within seven months. Both of the patients had symptoms of infection and anemia and were therefore treated with antibiotics and transfusions. The SR lasted for two months and one month, respectively. Currently, the mechanisms underlying SR remain ambiguous. Possible underlying mechanisms with a review of the related literature are discussed.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Remission in Patients with Acute Myeloid Leukemia with t(8;21) or Cutaneous Myeloid Sarcoma: Two Case Reports and a Review of the Literature

et al. 2013

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“…However, later there was recurrence of tumor. Whether the pomegranate juice played a role in the patient’s spontaneous remission remains a matter of speculation [84]. …”

Section: Anti-cancer Effects Of Pomegranatementioning

confidence: 99%

Pomegranate Extracts and Cancer Prevention: Molecular and Cellular Activities

Syed¹,

Chamcheu²,

Adhami³

et al. 2013

ACAMC

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There is increased appreciation by the scientific community that dietary phytochemicals can be potential weapons in the fight against cancer. Emerging data has provided new insights into the molecular and cellular framework needed to establish novel mechanism-based strategies for cancer prevention by selective bioactive food components. The unique chemical composition of the pomegranate fruit, rich in antioxidant tannins and flavonoids has drawn the attention of many investigators. Polyphenol rich fractions derived from the pomegranate fruit have been studied for their potential chemopreventive and/or cancer therapeutic effects in several animal models. Although data from in vitro and in vivo studies look convincing, well designed clinical trials in humans are needed to ascertain whether pomegranate can become part of our armamentarium against cancer. This review summarizes the available literature on the effects of pomegranate against various cancers.

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“…All cases experienced a relapse with time ranging from 2 weeks to 14 months with relapsed blast phenotype similar to reported phenotype at presentation. [8][9][10][11][12][13][14][15] All but two patients reached CR after chemotherapy induction, while one was lost to follow-up and the other patient died from unrelated causes. 16 T A B L E 1 Summary of clinical presentation of the nine patients with spontaneous remission.…”

Section: Comprehensive Review Of Literaturementioning

confidence: 98%

“…Our results are concordant with previously reported cases of spontaneous remission of ALL reported in the literature. [8][9][10][11][12][13][14][15] Analysis of nine case reports identified from literature search (Table 3) showed reported age range from 15 months to 50 years (three pediatric cases, and seven adult cases). All reported patients presented with either viral or bacterial infection.…”

Section: Comprehensive Review Of Literaturementioning

confidence: 99%

Spontaneous remission of acute lymphoblastic leukemia: A series of nine cases and a review of literature

Kirtek

Hamdan

Arnam

et al. 2023

Int J Lab Hematology

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Aims To report a series of acute lymphoblastic leukemia (ALL) cases with spontaneous remission and provide presenting clinical and pathologic information and details of clinical course to raise awareness among oncologists and patients. Methods We identified and analyzed nine patients with ALL and spontaneous remission. Review of literature reveals an additional nine previously reported cases with similar clinical course. Results All of these patients, ranging in age from 2 to 12 years of age, presented with inciting signs and symptoms of viral or bacterial infection. All of the patients showed varying percentages of lymphoblasts (.2% to 90%) in diagnostic bone marrow biopsy. All B‐ALL cases shared a similar blast phenotype on flow cytometry with coexpression of CD19, CD10 and TdT and variable CD20 expression. All nine patients achieved spontaneous remission of their leukemia as confirmed by flow cytometry and/or bone marrow biopsy without chemotherapeutic intervention. Time to remission from presentation ranged from 1 to 8 weeks. After remission, all patients redeveloped ALL, and time from remission to reemergence ranged from 2 to 24 weeks. Conclusion Our series of cases and cases identified in literature show that ALL diagnosed with modern methods of flow cytometry and molecular analysis will recur within weeks to months from disappearance, usually with cytopenias, which provides a template for oncologic follow‐up and testing in these patients.

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Spontaneous remission of T lymphoblastic lymphoma

Cited by 9 publications

References 5 publications

Spontaneous Remission in Patients with Acute Myeloid Leukemia with t(8;21) or Cutaneous Myeloid Sarcoma: Two Case Reports and a Review of the Literature

Spontaneous Remission in Patients with Acute Myeloid Leukemia with t(8;21) or Cutaneous Myeloid Sarcoma: Two Case Reports and a Review of the Literature

Pomegranate Extracts and Cancer Prevention: Molecular and Cellular Activities

Spontaneous remission of acute lymphoblastic leukemia: A series of nine cases and a review of literature

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