Spontaneous remission following bone marrow necrosis in chronic lymphocytic leukaemia

Hughes, Richard G.M.; Islam, Anwarul; Lewis, S. M.; Catovsky, Daniel

doi:10.1111/j.1365-2257.1981.tb01328.x

Cited by 16 publications

(7 citation statements)

References 14 publications

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“…Bone marrow necrosis was described in the context of lymphoma in 35 patients (15%). 4,7,14,21,23,27,35,39,46,52,[61][62][63][64][65][66][67][68][69][70][71][72][73][74] The association was observed with aggressive lymphoma, with indolent lymphoid malignancies like chronic lymphocytic leukemia 4,65 or hairy cell leukemia, 72 and with moderately aggressive disorders like follicle center lymphoma 69 and multiple myeloma. 66 Furthermore, BMN has been reported in association with Hodgkin disease in five cases.…”

Section: Underlying Disease Associationsmentioning

confidence: 99%

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Bone marrow necrosis

Janssens

Offner

Hove

2000

Cancer

118

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Section: Underlying Disease Associationsmentioning

confidence: 99%

“…This contrasts with the findings of aplastic anemia in which there is only a loss of myeloid tissue and no destruction of the reticular structure. 4 Usually there is no destruction of the spicular architecture as is seen in aseptic necrosis. 5 …”

mentioning

confidence: 98%

Bone marrow necrosis

Janssens

Offner

Hove

2000

Cancer

118

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“…It has been described in different series with frequencies varying between 0.5 to 37% of sequential bone marrow biopsies [1,2]. Varying degrees of BMN have been associated with multiple clinical conditions including: acute myelogenous leukemia [3], chronic myelogenous leukemia [4], acute lymphocytic leukemia [4][5][6][7], chronic lymphocytic leukemia [8], hairy cell leukemia [9], lymphoma [10,11], all-trans retinoic acid therapy [12], fludarabine [13], Escherichia coli sepsis [14], antiphospholipid syndrome [15,16], sickle cell disease [17], primary thrombocythemia [18], adenocarcinoma of unknown primary [19,20], Pseudomonas aerugenosa sepsis [19], mucor infection [21], idiopathic [22], and anorexia nervosa [23]. BMN is most often recognized on post mortem evaluation [11].…”

Section: Introductionmentioning

confidence: 99%

Pancytopenia due to bone marrow necrosis in acute myelogenous leukemia: Role of reactive CD8 cells

Markovic

Phyliky

1998

Am. J. Hematol.

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Bone marrow necrosis is a rare clinical condition often associated with hematological malignancy. The mechanism by which malignant disease causes marrow necrosis is unknown. We present a case of a patient with newly diagnosed pancytopenia with bone marrow biopsy evidence of extensive marrow necrosis. Upon further work-up utilizing Tc bone scan directed bone marrow biopsy, a massive CD8+ T cell marrow infiltrate was discovered engulfing AML-M2 blasts. The role of Tc bone scans in the work-up of bone marrow necrosis as well as the potential mechanism of AML-M2 induced marrow necrosis in the setting of reactive CD8+ T cell infiltration is discussed. Am. J. Hematol. 59:74-78, 1998.

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“…Apoptosis and bone marrow necrosis have been known to be associated with a spontaneous remission of some malignant diseases 3 4. Although the mechanism of such remissions remains unknown, it is thought to be the result of an efficient immune response against malignant cells.…”

Section: Discussionmentioning

confidence: 99%

Intramarrow injection needle: a new technique to treat patients with haematological and non-haematological malignancies by directly injecting therapeutic agents into the bone marrow cavity

Islam

2020

J Clin Pathol

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AimsThe purpose of this report is to describe a new instrument designed for the injection of therapeutic agents directly into the bone marrow cavity as well as to aspirate bone marrow specimens for the diagnostic purposes.MethodsThe instrument consists of three parts: the needle, stilette and an adjustable guard. The overall length of the needle is 76 mm and has uniform external diameter except for the distal penetrating segment, which is sharp but short and safe to use on the sternum. The proximal end of the needle is fitted with a plastic T-bar handle, which is ergonomically designed for firm grip and easy manoeuvrability.ResultsThe instrument has been designed to obtain bone marrow aspirate specimens as well as to inject therapeutic agents into the posterior ilium.ConclusionsThe rationale for the intramedullary injection of therapeutic agents for the treatment of patients with leukaemia, lymphoma and other haematological and non-haematological malignant disorders is described. In an emergency when intravenous therapy becomes difficult due to collapsed veins, this instrument may be used for direct intramarrow infusion of blood and blood products.

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Spontaneous remission following bone marrow necrosis in chronic lymphocytic leukaemia

Cited by 16 publications

References 14 publications

Bone marrow necrosis

Bone marrow necrosis

Pancytopenia due to bone marrow necrosis in acute myelogenous leukemia: Role of reactive CD8 cells

Intramarrow injection needle: a new technique to treat patients with haematological and non-haematological malignancies by directly injecting therapeutic agents into the bone marrow cavity

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