Spontaneous Regression of FDG/PET Positive Lung Adenocarcinoma in an Elderly Man

Miyoshi, Yukari; Takayashiki, Norio; Satoh, Hiroaki

doi:10.5603/arm.a2017.0040

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…All of them concerned patients with hematological malignancies, except for one patient with lung cancer . In this patient with lung cancer, squamous cell carcinoma was confirmed pathologically by surgical resection performed several months after PET/CT scan .…”

Section: Discussionmentioning

confidence: 94%

“…Tumors derived from embryonic stem cells and tumors related to hormonal secretions, the most commonly described of which are adenocarcinoma of the kidney, neuroblastoma, melanoma, and some sarcomas, have a greater capacity for SR. Certain previous studies have reported SR of metastatic lesions following removal of the primary lesion, whereas other studies have reported SR associated with infection . There have been some reports on spontaneous regression of FDG/PET‐positive tumors . All of them concerned patients with hematological malignancies, except for one patient with lung cancer .…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous regression of metastatic squamous cell lung cancer

Ariza‐Prota

Martínez

Casán

2018

Clinical Case Reports

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of metastatic squamous cell lung cancer

Ariza‐Prota

Martínez

Casán

2018

Clinical Case Reports

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LncRNA-135528 inhibits tumor progression by up-regulating CXCL10 through the JAK/STAT pathway

et al. 2018

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Spontaneous tumor regression can be observed in many tumors, however, studies related to the altered expression of lncRNA in spontaneous glioma regression are limited, and the potential contributions of lncRNAs to spontaneous glioma regression remain unknown. To investigate the biological roles of lncRNA-135528 in spontaneous glioma regression. The cDNA fragment of lncRNA-135528 was obtained by rapid-amplification of cDNA ends (RACE) technology and cloned into the plvx-mcmv-zsgreen-puro vector. Additionally, we stably silenced or overexpressed lncRNA-135528 in G422 cells by transfecting with siRNA against lncRNA-135528 or lncRNA-135528 overexpression plasmid. Then, we examined lncRNA-135528 overexpressing and lncRNA-135528 silencing on glioma cells and its effects on CXCL10 and JAK/STAT pathways. The main findings indicated that lncRNA-135528 promoted glioma cell apoptosis, inhibited cell proliferation and arrested cell cycle progression; the up-regulation of lncRNA135528 led to significantly increased CXCL10 levels and the differential expression of mRNA associated with JAK/STAT pathway in glioma cells. lncRNA-135528 can inhibit tumor progression by up-regulating CXCL10 through the JAK/STAT pathway.

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Spontaneous regression of ALK fusion protein-positive non-small cell lung carcinoma: a case report and review of the literature

Walls

Walls²,

James

et al. 2020

BMC Pulm Med

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Background: ALK-rearrangement is observed in < 5% non-small cell lung cancer (NSCLC) cases and prior to the advent of oral tyrosine kinase inhibitors, the natural history of oncogenic NSCLC was typically poor. Literature relating to regression of treatment-naïve NSCLC is limited, and regression without treatment has not been noted in the ALK-rearranged sub-population. Case presentation: A 76 year old 'never smoker' female with an ALK-rearranged left upper lobe T2 N0 NSCLC experienced a stroke following elective DC cardioversion for new atrial fibrillation. Following a good recovery, updated imaging demonstrated complete regression of the left upper lobe lesion and a reduction of the previously documented mediastinal lymph node. Remaining atelectasis was non-avid on repeat PET-CT imaging, 8 months from the baseline PET-CT. When the patient developed new symptoms 6 months later a further PET-CT demonstrated FDG-avid local recurrence. She completed 55 Gy in 20 fractions but at 18 months post-radiotherapy there was radiological progression in the lungs with new pulmonary metastases and effusion and new bone metastases. Owing to poor performance status, she was not considered fit for targeted therapy and died 5 months later. Conclusion: All reported cases of spontaneous regression in lung cancer have been collated within. Documented precipitants of spontaneous regression across tumour types include biopsy and immune reconstitution; stroke has not been reported previously. The favourable response achieved with radical radiotherapy alone in this unusual case of indolent oncogenic NSCLC reinforces the applicability of radiotherapy in locally advanced ALK-rearranged tumours, in cases not behaving aggressively. As a common embolic event affecting the neurological and pulmonary vasculature is less likely, an immune-mediated mechanism may underpin the phenomenon described in this patient, implying that hitherto unharnessed principles of immuno-oncology may have relevance in oncogenic NSCLC. Alternatively, high electrical voltage applied percutaneously adjacent to the tumour during cardioversion in this patient may have induced local tumour cell lethality.

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Spontaneous Regression of FDG/PET Positive Lung Adenocarcinoma in an Elderly Man

Cited by 3 publications

References 12 publications

Spontaneous regression of metastatic squamous cell lung cancer

Spontaneous regression of metastatic squamous cell lung cancer

LncRNA-135528 inhibits tumor progression by up-regulating CXCL10 through the JAK/STAT pathway

Spontaneous regression of ALK fusion protein-positive non-small cell lung carcinoma: a case report and review of the literature

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