Spontaneous reactivation of chronic hepatitis B virus infection

Determinants of the clinical outcome of patients with severe acute exacerbation of chronic hepatitis B virus infection

“…Up to 30% of patients with CHB infection experience reactivation of hepatitis every year [5,6], while some patients develop acute exacerbation with jaundice and coagulopathy, a severe lifethreatening condition with high mortality [9,12]. It is important to determine the predicting factors of progression to liver decompensation in patients with acute exacerbation.…”

“…Other complications of HBV infection include fulminant hepatitis and acute liver failure [3,4]. Acute exacerbation (AE) in HBV carriers occurs either through a natural course [5,6] or following intensive chemotherapy or immunosuppressive therapy [7,8]. Some abrupt flares may be so severe that decompensation or even fulminant hepatic failure may occur [9][10][11].…”

Nucleoside Analogue Can Improve the Long-Term Prognosis of Patients with Hepatitis B Virus Infection-Associated Acute on Chronic Liver Failure

“…Based on cumulating experience of ACLF, many findings suggest that excessive activation of a patient's immune function by Fas and tumor necrosis factor (TNF) receptors in the liver plays an essential role in development of the ACLF caused by hepatitis B virus infection [7,8]. On the other hand, recent literature has shown that it is probably caused by recurrence of HBV replication, and has been associated with decompensation of liver disease [9][10][11].…”

A Study Into the Risk of Exacerbation of Chronic Hepatitis B After Liver Resection for Hepatocellular Carcinoma

“…In the natural disease course of chronic HBV infection, evidence of HBV replication characterized by high HBV DNA load and HBeAg positive status would often precede a hepatitis flare 10 . We did not observe HBeAg positive status, high preoperative ALT level, or high HBV DNA level to be significant risk factors for ECHB postsurgery.…”