Spontaneous Pulmonary Hemangiosarcoma in a Norway Rat (Rattus norvegicus)

Smith, Geary R.; Nemeth, Nicole M.; Howerth, Elizabeth W.; Butler, Abigail M.; Gottdenker, Nicole

doi:10.1053/j.jepm.2013.11.016

Cited by 6 publications

(5 citation statements)

References 22 publications

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“…No histopatológico foram encontradas células com pleomorfismo, anisocitose, anisocariose e basofilia acentuados e nucléolos evidentes, formadas em canais e lacunas estratificadas pouco preenchidas por sangue. Aspecto compatível com hemangiossarcoma pouco diferenciado, características também encontradas por Smith et al (2014) em seu relato de Rattus norvergicus. A quantidade reduzida de hemácias nas estruturas vasculares encontradas na formação também é uma característica vista nos linfangiossarcomas (GROSS et al, 2005).…”

Section: Discussionunclassified

“…Na necrópsia foram visualizadas neoformações em pulmões, metástase comum também relatada por Smith et al (2014). Na cavidade abdominal, moderada quantidade de líquido sanguinolento, característica encontrada neste mesmo estudo, porém o paciente não havia características de coagulação intravascular disseminada como a presença de trombos, por exemplo (SMITH et al, 2014).…”

Section: Discussionunclassified

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Hemangiossarcoma em hamster sírio (Mesocricetus auratus) – relato de caso / Hemangiosarcoma in a syrian hamster (Mesocricetus auratus) – case report

Machado

Salzedas²,

Segala

et al. 2021

BJAER

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RESUMOO hemangiossarcoma (HSA) é uma neoplasia originada do endotélio vascular sanguíneo, de caráter maligno com comportamento agressivo e metastático, apresentando-se principalmente em fígado, baço e pulmões, devido à rápida disseminação celular por via hematogênica. Um hamster sírio (Mesocricetus auratus) fêmea de um ano de idade apresentou uma formação de consistência firme, com dor a palpação, de evolução rápida e progressiva. O animal foi encaminhado para citologia e radiografia onde evidenciou-se neoplasia maligna sendo indicada a retirada da formação. Depois de realizada a cirurgia o tecido foi encaminhado para o histopatológico sugerindo hemangiossarcoma pouco diferenciado, tendo indicação de realizar um exame imunohistoquímico, que não foi realizado devido o animal vir a óbito. Na necrópsia foram encontradas formações metastáticas em fígado, baço e pulmão, com líquido sanguinolento na cavidade devido à ruptura de nódulo em baço o que pode ter levado ao um choque hipovolêmico.

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Section: Discussionunclassified

Hemangiossarcoma em hamster sírio (Mesocricetus auratus) – relato de caso / Hemangiosarcoma in a syrian hamster (Mesocricetus auratus) – case report

Machado

Salzedas²,

Segala

et al. 2021

BJAER

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“…Thoracic lesions due to infectious agents can lead to dyspnea, which is a common cause of presentation of rats to exotic practitioners . Conversely, spontaneous thoracic neoplasms are rare and may be misdiagnosed . Rats are used as model for carcinogen‐induced pulmonary tumors in humans, and the most common primary pulmonary tumors of rats are alveolar adenomas and carcinomas arising from type II pneumocytes and Clara cells .…”

Section: Introductionmentioning

confidence: 99%

“…Rats are used as model for carcinogen‐induced pulmonary tumors in humans, and the most common primary pulmonary tumors of rats are alveolar adenomas and carcinomas arising from type II pneumocytes and Clara cells . Spontaneous pulmonary hemangiosarcoma and thoracic rhabdomyosarcoma have also been described. Secondary thoracic neoplasms of rats include mesotheliomas, lymphomas, histiocytic sarcomas, and metastatic mammary adenocarcinomas among others .…”

Section: Introductionmentioning

confidence: 99%

COMPARISON BETWEEN THORACIC RADIOGRAPHIC FINDINGS AND POSTMORTEM DIAGNOSIS OF THORACIC DISEASES IN DYSPNEIC COMPANION RATS (RATTUS NORVEGICUS)

Fouriez-Lablee

Vergneau‐Grosset

Kass

et al. 2016

Vet Radiology Ultrasound

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Companion rats are often presented to veterinarians for respiratory difficulties. Dyspnea in rats is most commonly due to infectious pneumonia, and thoracic neoplasia can go undiagnosed ante mortem due to a mistaken interpretation of pneumonia. In domestic carnivores, pulmonary nodular patterns have been shown to correlate with lung neoplastic diseases and infectious diseases. The main objective of this retrospective case series study was to determine whether certain radiographic criteria could be correlated with the presence of thoracic infectious disease and neoplastic disease in companion rats. A secondary objective was to determine whether the patient's sex and age were different between rats diagnosed with infectious versus neoplastic disease. Medical records and thoracic radiographs of dyspneic companion rats presented to the University of California at Davis, William R. Pritchard Veterinary Medical Teaching Hospital during the time period from January 2000 to December 2014 were reviewed. Rats with postmortem confirmation of thoracic lesions were included in the study. Thoracic radiographs were evaluated for positioning, lesion distribution, lung lobe involved, pulmonary pattern, mediastinal and pleural lesions by three observers blinded to diagnosis. Thirty rats were included in the study, including 23 rats with an infectious disease and seven with neoplasia. Mediastinal lesions were significantly more prevalent in the group diagnosed with thoracic neoplasia (P = 0.031), in particular cranially (P = 0.048). Although there was an overlap between the two groups, findings indicated that the presence of cranial mediastinal lesions may be helpful for differentiating neoplastic from infectious disease in rats.

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“…There are only a few case reports 8 , 9 on young rats. Although the spleen is reported to be the most frequent site of the primary lesion in rats 7 , the tongue 8 , pancreas 10 , lung 11 , and mesenteric lymph node 12 have also been reported as sites of primary lesions. Metastasis is often present 1 , and cases of distant metastasis have also been reported 8 , 9 .…”

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confidence: 99%

Metastatic hemangiosarcoma of the liver in a young rat

2017

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Spontaneous hemangiosarcoma is generally uncommon in rats. Furthermore, there are only a few case reports in young rats. This report describes a spontaneous hemangiosarcoma in a young 7-week-old rat. At necropsy, no remarkable changes were noted in any organs including the liver. Histopathologically, multifocal small tumors were located mainly in the perilobular region of the liver. The tumors comprised polygonal to short spindle-shaped cells that showed cellular atypia and local infiltration. In the foci, there were blood-filled spaces lined by spindle-shaped cells. Reticular fibers, which were loosely connected together and formed an irregular network within the foci, were noticed with Azan and silver stain. Immunohistochemistry revealed that tumor cells expressed vascular endothelial cell markers: von willebrand factor and CD34, respectively. These features indicate that the tumor originated from vascular endothelial cells. Although the primary lesion was uncertain, the foci were all small and multicentrically located mainly in the perilobular region, indicating that the liver lesion likely formed by hematogenic metastasis. Taken together, we diagnosed this case as a metastatic hemangiosarcoma.

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Spontaneous Pulmonary Hemangiosarcoma in a Norway Rat (Rattus norvegicus)

Cited by 6 publications

References 22 publications

Hemangiossarcoma em hamster sírio (Mesocricetus auratus) – relato de caso / Hemangiosarcoma in a syrian hamster (Mesocricetus auratus) – case report

Hemangiossarcoma em hamster sírio (Mesocricetus auratus) – relato de caso / Hemangiosarcoma in a syrian hamster (Mesocricetus auratus) – case report

COMPARISON BETWEEN THORACIC RADIOGRAPHIC FINDINGS AND POSTMORTEM DIAGNOSIS OF THORACIC DISEASES IN DYSPNEIC COMPANION RATS (RATTUS NORVEGICUS)

Metastatic hemangiosarcoma of the liver in a young rat

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