Metastatic hemangiosarcoma of the liver in a young rat

Abstract

Spontaneous hemangiosarcoma is generally uncommon in rats. Furthermore, there are only a few case reports in young rats. This report describes a spontaneous hemangiosarcoma in a young 7-week-old rat. At necropsy, no remarkable changes were noted in any organs including the liver. Histopathologically, multifocal small tumors were located mainly in the perilobular region of the liver. The tumors comprised polygonal to short spindle-shaped cells that showed cellular atypia and local infiltration. In the foci, there were blood-filled spaces lined by spindle-shaped cells. Reticular fibers, which were loosely connected together and formed an irregular network within the foci, were noticed with Azan and silver stain. Immunohistochemistry revealed that tumor cells expressed vascular endothelial cell markers: von willebrand factor and CD34, respectively. These features indicate that the tumor originated from vascular endothelial cells. Although the primary lesion was uncertain, the foci were all small and multicentrically located mainly in the perilobular region, indicating that the liver lesion likely formed by hematogenic metastasis. Taken together, we diagnosed this case as a metastatic hemangiosarcoma.

Spontaneous hemangiosarcoma in the spleen and liver of a young rat

“…In one report, splenic hemangiosarcoma was observed in a 9-week-old SD rat, comprising a dense sheet of pleomorphic cells frequently observed in undifferentiated tumors and intravascular metastasis to the liver 8 . In another report, similar histological features were observed in metastasized hepatic hemangiosarcoma of a 7-week-old SD rat 9 . The morphological features of these case reports, including this case, reflect the unique characteristics of hemangiosarcoma in young SD rats: extremely undifferentiated histological images without formation of clear vascular structures.…”

“…In addition, it has been reported that spontaneous hemangiosarcoma is commonly found in rats aged 91 weeks or older 6 . Only a few cases have been reported in young rats [7][8][9] . In this report, we elucidate the occurrence of spontaneous hemangiosarcoma in the spleen and liver of young rats and describe the histological, immunohistological, and ultrastructural features of this tumor.…”

Exploiting the synergistic effects of combined carbon‐based materials for rape drug diazepam electrochemical sensing: Application to simulated casework matrices

“…Alprazolam and DZP are among the most abused psychotropic substances. When combined with alcohol, they can potentiate the depressant effect of the central nervous system and are thus used as facilitating drugs for sexual abuse crimes [4, 5]. In instances of suspected misuse or acute intoxication related to BZDs, the toxicological analysis involves a three‐step process: initial screening for substance class identification, utilizing spectroscopic and/or chromatographic techniques for specific substance identification, and subsequent quantification of the BZD molecules [6].…”