Spontaneous Pseudohypopyon Secondary to Diffuse Infiltrating Retinoblastoma

The pathology of ocular cancer

“…A relatively rare (1.5% of cases) growth pattern called diffuse infiltrative retinoblastoma occurs in older children (mean age 6 years). 50 In such cases, the retina is diffusely thickened by tumor, does not form a distinct tumefaction and usually lacks calcification. Tumor cells typically blanket the ciliary body, infiltrate the zonule and seed the anterior chamber forming a pseudohypopyon of tumors cells that may be misinterpreted as inflammation, leading to an inappropriate invasive procedure.…”

Ultrasonic findings in intraocular retinoblastoma and correlation with histopathologic diagnosis

“…These tumors may contain little or no calcium. Diffuse, noncalcified retinoblastomas are frequently associated with clinical signs of inflammation like hypopyon [12,13]. In six of seven patients with diffuse infiltrating retinoblastoma ultrasound examination showed no evidence of an intraocular mass [14].…”

Retinoblastoma

“…3.8). Other presentation is the diffuse infiltrating retinoblastoma where the tumor expands the entire retina without forming a discrete tumor mass and it tends to invade the anterior segment with a pseudohypopyon (McLean et al 1994;Hurwitz et al 2002;Chévez-Barrios et al 2007;Croxatto et al 1983;Shields et al 1988). …”