Spontaneous platelet aggregation as a predictive risk factor for vascular occlusions in healthy volunteers? Results of the HAPARG Study

Breddin, H. K.; Lippold, Rainer; Bittner, Magaly Rodríguez de; Kirchmaier, C. M.; Krzywanek, H. J.; Michaelis, Jörg

doi:10.1016/s0021-9150(99)00056-8

Cited by 50 publications

(45 citation statements)

References 46 publications

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“…10 Similarly, increased platelet aggregation in response to endothelin could contribute to thrombosis. 11 As a result of activation, platelets change from the normal disc shape to a sphere with long, dendritic extensions that facilitate adhesion.…”

Section: Evidence Of Platelet Activation In Hypertensionmentioning

confidence: 99%

Pharmacological Modulation of Platelet Function in Hypertension

2003

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Abstract-Platelets exert a considerable influence on human morbidity and mortality. The rationale for their study in hypertension follows the observation that the major consequences of hypertension are stroke and myocardial infarction. However, the etiology of these consequences in hypertension is, paradoxically, not hemorrhagic (as might be expected from the effects of high blood pressure), but occlusive, with thrombus being the culprit lesion. Mechanisms of platelet activation include high shear force, activation of the renin-angiotensin system, endothelial changes, and the presence of comorbidity, such as atrial fibrillation. The treatment of high blood pressure brings about a reversal of the changes seen in the cell. This could be in part due to the direct effect of the drug on the megakaryocyte and/or the platelets themselves, or it might simply be due to the reduction in blood pressure. Some drugs, such as calcium channel antagonists and angiotensin II receptor blockers, however, might have direct effects on platelet biochemistry other than reducing blood pressure. Finally, antiplatelet drugs are becoming an important part of the management of high-risk hypertensives, which aim to minimize vascular complications. (Hypertension. 2003;42:1-7.)

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Section: Evidence Of Platelet Activation In Hypertensionmentioning

confidence: 99%

Pharmacological Modulation of Platelet Function in Hypertension

2003

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“…One of the fi rst reports by Wu et al [1] suggested that enhanced platelet aggregation in platelet aggregometry might be an important risk factor for recurrent venous thrombosis. Breddin et al [2] demonstrated a positive correlation between spontaneously enhanced platelet aggregation and vascular occlusions. Similar fi ndings were observed for idiopathic thrombosis in childhood [3] .…”

Section: Introductionmentioning

confidence: 96%

Platelet Activation Markers in Patients with Venous Thromboembolism without Predisposing Factors

Gerdsen¹,

Weber²,

Eifrig³

et al. 2005

Pathophysiol Haemos Thromb

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A constant in vitro hypersensitivity of platelets (adenosine diphosphate) has been suggested as a risk factor for arterial and even venous thrombosis. Our aim was to determine phenotypic and functional alterations of platelets by flow cytometry as potential prothrombotic risk factors in patients with a history of unexplained spontaneous venous thrombosis. Forty-nine patients with a history of spontaneous venous thrombosis and no inherited or acquired thrombophilic risk factors were compared with a reference group of 39 healthy volunteers. Flow cytometry (FACS) was used to analyze the surface expression of CD62 (P-selectin) and CD63 in nonactivated platelets and after in vitro stimulation with adenosine diphosphate and thrombin receptor activator peptide 6. Mean fluorescence intensity of CD62 and CD63 surface expression as well as percentage of CD62 and CD63 positive cells and binding index differed in patients with a history of thrombosis compared with the reference group, but failed to reach statistical significance. Similar results were observed after in vitrostimulation with adenosine diphosphate and thrombin receptor activator peptide 6. In conclusion, the expression of CD62 and CD63 of resting and in vitro activated platelets could not be established as a risk factor for spontaneous venous thromboembolism.

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“…Spontaneous platelet aggregation, defined as formation of small aggregates under constant stirring in the absence of any agonists, is rare in healthy individuals but seen in some cases of von Willebrand disease [132], in some patients with diabetes [133] and in some lipid disorders [134], and may be an indicator of an ongoing active atherosclerotic process [135]. platelets and megakaryocytes is given by Woulfe et al [173].…”

Section: Platelet Aggregometrymentioning

confidence: 99%

State of the Art in Platelet Function Testing

Kehrel

Brodde

2013

Transfus Med Hemother

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Platelets perform many functions in hemostasis but also in other areas of physiology and pathology. Therefore, it is obvious that many different function tests have been developed, each one conceived and standardized for a special purpose. This review will summarize the different fields in which platelet function testing is currently in use; diagnostics of patients with bleeding disorders, monitoring patients' response to anti-platelet therapy, monitoring in transfusion medicine (blood donors, platelet concentrates, and after transfusion), and monitoring in perioperative medicine to predict bleeding tendency. The second part of the review outlines different methods for platelet function testing, spanning bleeding time, and platelet counting as well as determining platelet adhesion, platelet secretion, platelet aggregation, platelet morphology, platelet signal transduction, platelet procoagulant activity, platelet apoptosis, platelet proteomics, and molecular biology.

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Spontaneous platelet aggregation as a predictive risk factor for vascular occlusions in healthy volunteers? Results of the HAPARG Study

Cited by 50 publications

References 46 publications

Pharmacological Modulation of Platelet Function in Hypertension

Pharmacological Modulation of Platelet Function in Hypertension

Platelet Activation Markers in Patients with Venous Thromboembolism without Predisposing Factors

State of the Art in Platelet Function Testing

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