1992
DOI: 10.1293/tox.5.223
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Spontaneous Pituitary Adenomas of The Pars Intermedia in Mice And Rats: Histopathological And Immunocytochemical Studies.

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Cited by 7 publications
(11 citation statements)
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“…However, there were no histological abnormalities such as adrenocortical hyperplasia related to this pars intermedia tumor. As in the case of this animal, it was reported that mice and rats with pars intermedia adenomas had no endocrinological abnormalities in the other organs including the adrenal glands 6 . On the other hand, there are interesting reports of pars intermedia adenoma affecting other organs and causing functional changes in horses and dogs.…”
supporting
confidence: 55%
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“…However, there were no histological abnormalities such as adrenocortical hyperplasia related to this pars intermedia tumor. As in the case of this animal, it was reported that mice and rats with pars intermedia adenomas had no endocrinological abnormalities in the other organs including the adrenal glands 6 . On the other hand, there are interesting reports of pars intermedia adenoma affecting other organs and causing functional changes in horses and dogs.…”
supporting
confidence: 55%
“…For example, the incidences of pars distalis neoplasm in B6C3F1 mice are reported as being approximately 0.2% and 15% for males and females, respectively, in the National Toxicology Program historical control database of the previous 2-year carcinogenicity studies 3 . In contrast, pituitary adenomas of the pars intermedia are uncommon neoplasms 1,5,6 , and pituitary carcinomas of the pars intermedia are extremely rare tumors in aging mice 3,7 . Previous reports have described the criteria for pituitary carcinoma of the pars intermedia as follows: (i) projection into a large cystic space; (ii) abutting against brain or bone without infiltrating brain or bone; (iii) infiltration into the meninges 7 .…”
mentioning
confidence: 99%
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“…The cells were positively stained with anti-a-MSH antibody. Ultrastructurally, these cells contained well-developed RER, Golgi saccules, and small secretory granules that were not seen in the PRL-secreting cells; hence, somewhat similar to these in pituitary adenoma cells of the pars intermedia (3,10 …”
mentioning
confidence: 79%
“…The tumor mass and intact tissue of the lobe were immunohistochemically positive for α-MSH ( Fig. 1H inset) and ACTH (data not shown), whereas the pars distalis was only positive for ACTH, suggesting that tumor cells were derived from the intermediate lobe 12 . In the tumor, enlarged cells with prominent nucleoli and mitoses were frequently observed ( Fig.…”
mentioning
confidence: 92%