Spontaneous Pituitary Adenomas of The Pars Intermedia in Mice And Rats: Histopathological And Immunocytochemical Studies.

Oishi, Yuji; Matsumoto, Masahiro; Yoshizawa, Katsuhiko; Fujihira, Shiro; Tsubura, Airo; Morii, Sotokichi

doi:10.1293/tox.5.223

Cited by 7 publications

(11 citation statements)

References 19 publications

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“…However, there were no histological abnormalities such as adrenocortical hyperplasia related to this pars intermedia tumor. As in the case of this animal, it was reported that mice and rats with pars intermedia adenomas had no endocrinological abnormalities in the other organs including the adrenal glands 6 . On the other hand, there are interesting reports of pars intermedia adenoma affecting other organs and causing functional changes in horses and dogs.…”

supporting

confidence: 55%

“…For example, the incidences of pars distalis neoplasm in B6C3F1 mice are reported as being approximately 0.2% and 15% for males and females, respectively, in the National Toxicology Program historical control database of the previous 2-year carcinogenicity studies 3 . In contrast, pituitary adenomas of the pars intermedia are uncommon neoplasms 1,5,6 , and pituitary carcinomas of the pars intermedia are extremely rare tumors in aging mice 3,7 . Previous reports have described the criteria for pituitary carcinoma of the pars intermedia as follows: (i) projection into a large cystic space; (ii) abutting against brain or bone without infiltrating brain or bone; (iii) infiltration into the meninges 7 .…”

mentioning

confidence: 99%

“…We chose these antibodies because the relevant hormones, except prolactin and PCNA, are proopiomelanocortin (POMC)-derived peptides 9 . Furthermore, the intermediate lobe of the pituitary gland is a major part of the POMC system in mice and rats 6 . The white nodule grossly resembled a tumor arising from the brain because the nodule adhered to and merged into the brain tissue.…”

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confidence: 99%

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Spontaneous Pituitary Carcinoma of the Pars Intermedia in a B6C3F1 Mouse

et al. 2008

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Abstract:We encountered one pituitary carcinoma derived from the pars intermedia in an untreated female B6C3F1 mouse in a carcinogenicity study. A white nodule (6 × 5 × 3 mm) was observed in the base of the brain at necropsy. Tumor cells were histologically arranged in a solid sheet or nest-like structures, and had round or oval nuclei and pale eosinophilic granular cytoplasm. Sporadic mitotic figures were seen in the tumor while necrosis was a prominent feature. In addition, distinct infiltration into the brain parenchyma was observed. Immunohistochemically, tumor cells were positive for α-melanocyte stimulating hormone (α-MSH), γ-melanocyte stimulating hormone (γ-MSH), β-endorphin and adenocorticotropic hormone (ACTH), but were negative for prolactin. However, there were no histological abnormalities such as adrenocortical hyperplasia related to the pars intermedia tumor. These results suggest that the tumor cells might not have actively secreted proopiomelanocortin (POMC)-derived peptides. The present report provides additional histopathological evidence of pituitary carcinoma of the pars intermedia in aging mice. (J Toxicol Pathol 2008; 21: 105-108)

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confidence: 99%

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Spontaneous Pituitary Carcinoma of the Pars Intermedia in a B6C3F1 Mouse

et al. 2008

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“…The cells were positively stained with anti-a-MSH antibody. Ultrastructurally, these cells contained well-developed RER, Golgi saccules, and small secretory granules that were not seen in the PRL-secreting cells; hence, somewhat similar to these in pituitary adenoma cells of the pars intermedia (3,10 …”

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confidence: 79%

A Case Report of Invasive Pituitary Tumors Containing Alpha-Melanocyte-Stimulating Hormone Arising from the Pars Distalis in F344 Rats

Satoh¹,

Kajimura²,

Yoshikawa³

2000

Toxicol Pathol

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Readers are invited to submit their own diagnostic challenges or unusual findings or to voice opinions and comments about the current lesion diagnosis or explanation. Cases for the "Tox Path Forum" should be sent to the Editorial Office with the following information: 1) species, sex, and age; 2) the nature/class of the test article (if any); 3) brief description and diagnosis; and 4) photographs or data. The information should not exceed two pages (including photographs). Submit both a hard copy and a diskette (Macintosh or PC) indicating version, to expedite rapid review and publication. Submissions will be reviewed for clarity and relevance to the journal readership. Comments (3,6,8,9,11 For immunohistochemical detection of a-MSH, prolactin (PRL), and proliferating cell nuclear antigen (PCNA), selected tissue sections were processed by a labeled streptavidin-biotin (LSAB) method. In brief, the paraffin section was deparaffinized, treated sequentially with rabbit anti-a-MSH antibody (1:500, Biogenesis, Inc, NH), rabbit anti-rat prolactin antibody (1:1,000, Chemicon International Co, Ltd, CA), or mouse anti-PCNA antibody (1:100, DAKO Japan Co., Ltd., Tokyo, Japan) as the primary antibody, followed by staining with an LSAB kit (DAKO Japan Co, Ltd

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“…The tumor mass and intact tissue of the lobe were immunohistochemically positive for α-MSH ( Fig. 1H inset) and ACTH (data not shown), whereas the pars distalis was only positive for ACTH, suggesting that tumor cells were derived from the intermediate lobe 12 . In the tumor, enlarged cells with prominent nucleoli and mitoses were frequently observed ( Fig.…”

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confidence: 92%

A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats

et al. 2020

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Histopathological information about spontaneous lesions in aged Hannover Wistar rats is limited. In this study, we describe spontaneous lesions found in 39 male RccHan:WIST rats used as a control in a carcinogenicity study. Neoplastic lesions were frequently seen in the endocrine system, such as pituitary adenomas in the pars distalis. This strain exhibited a high incidence of thymoma (10.3%), compared to other strains. We encountered an oligodendroglioma, a pituitary adenoma of the pars intermedia, and a prostate adenocarcinoma, which are comparatively rare in rats. While the variety and incidence of non-neoplastic lesions were similar to those in other strains, several interesting lesions occurred with relatively high incidence, including "harderianization" of the extraorbital lacrimal gland, common bile duct ectasia, and hyperplasia of pulmonary endocrine cells in the lung. Furthermore, comparative analyses demonstrated that the severity of chronic progressive nephropathy and murine progressive cardiomyopathy in RccHan:WIST rats was less than that in F344 rats. (

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Spontaneous Pituitary Adenomas of The Pars Intermedia in Mice And Rats: Histopathological And Immunocytochemical Studies.

Cited by 7 publications

References 19 publications

Spontaneous Pituitary Carcinoma of the Pars Intermedia in a B6C3F1 Mouse

Spontaneous Pituitary Carcinoma of the Pars Intermedia in a B6C3F1 Mouse

A Case Report of Invasive Pituitary Tumors Containing Alpha-Melanocyte-Stimulating Hormone Arising from the Pars Distalis in F344 Rats

A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats

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