Spontaneous (pathologic) rupture of the spleen in previously undiagnosed Hodgkin's disease.Report of a case with survival

Abstract

Spontaneous (pathologic) rupture of the spleen in lymphoma is a rare event. A 38-year-old man with a 6-week history of fever, night sweats, and weight loss, and with known splenomegaly presented in shock as a result of a ruptured spleen. There was no known antecedent trauma. Hodgkin's disease was demonstrated in the spleen and liver. Review of the literature failed to reveal any previous report of spontaneous rupture of the spleen due to undiagnosed Hodgkin's disease. Only one survivor of spontaneous rupture of the lymphomatous spleen has been reported previously.

Simultaneous Rupture of the Liver and Spleen in a Patient on Warfarin Therapy: Report of a Case

“…Hematological cancers such as acute lymphocytic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, Hodgkin's lymphoma, viral infections with Epstein-Barr, hepatitis, human immunodeficiency virus, and bacterial infections such as pneumonia, meningococcemia, endocarditis, tuberculosis, dengue fever, Legionnaire's disease, Q fever, fungal infections, pancreatitis, rheumatologic diseases (such as systemic lupus erythematosus), immune thrombocytopenic purpura, rheumatoid arthritis, polyarteritis nodosum, Wegener's granulomatosis, and pregnancy are included in the wide spectrum of conditions predisposing to SSR. 1,[5][6][7][8] Worldwide, the most common infectious agent associated with SSR is malaria. 1,9 There are also reports describing SSR in patients with amyloidosis.…”

B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure

“…B-cell hepatosplenic lymphoma (BCHSL) is strikingly rare, with only a handful of published cases 11. Splenic rupture is an unusual presenting sign of lymphoma—we only located 29 reported cases12–41 (online supplemental table 1). Given the rarity of BCHSL, it is not surprising that our case is the first report of this lymphoma presenting with splenic rupture and subsequently the Warburg effect.…”

Spontaneous (pathological) rupture of the spleen in non-Hodgkin's lymphoma

“…Spontaneous rupture of 'normal' spleens is al. 1984), and has been reported as a presenting feature of Hodgkin's lymphoma (Beshara 1982;Dobrow 1977).…”

“…Our review of the literature to date has found eight cases of splenic rupture in patients with non-Hodgkin's lymphoma (Dobrow 1977;Littlefield 1946;Papp & Penner 1971;Thomson 1969 Three possible mechanisms which could lead to spontaneous splenic rupture in haematological malignancies have been suggested (Thomson 1969), namely a bleeding diathesis and subcapsular haematoma forrnation, infarction, or direct distension and infiltration of the capsule itself by tumour.…”