Spontaneous (pathological) rupture of the spleen in non-Hodgkin's lymphoma

Matt, Morgan; Deeble, T J

doi:10.1111/j.1365-2257.1989.tb00199.x

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…The spleen may also rupture without any obvious trauma; pathological conditions that pre-dispose to this include infections, including infectious mononucleosis [6], and tropical diseases like malaria [7]. The spleen may also rupture as a complication of haematological malignancy [13] and as a result of its increased friability after sepsis [4,5] and pneumonia [3,5,14]. Rupture may also be associated with rheumatoid conditions [15] and anticoagulation with warfarin or heparin, thrombolysis with streptokinase [16] and even prophylactic heparin use [17].…”

Section: Discussionmentioning

confidence: 99%

Occult splenic rupture with cardiovascular collapse: a report of three cases in critically ill patients

Kandasamy

Thomas

Reeve

2002

Intensive Care Medicine

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Three cases of splenic rupture causing cardiovascular collapse in critically ill patients are discussed. The first patient had received cardiopulmonary resuscitation (CPR) in the days before the collapse, the second patient was recovering from severe sepsis and the third patient was recovering from severe sepsis, had received CPR and had undergone percutaneous endoscopic gastrostomy (PEG). The diagnosis was made at post mortem in two of the patients, the third patient, who bled following PEG, survived after prompt surgical intervention. Splenic rupture should be considered as part of the differential diagnosis of unexpected cardiovascular collapse in patients who have received CPR or who are recovering from sepsis.

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Section: Discussionmentioning

confidence: 99%

Occult splenic rupture with cardiovascular collapse: a report of three cases in critically ill patients

Kandasamy

Thomas

Reeve

2002

Intensive Care Medicine

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Pathologic rupture of the spleen in hematologic malignancies: two additional cases

Giagounidis

Burk

Meckenstock

et al. 1996

Annals of Hematology

107

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Pathologic rupture of the spleen in hematologic malignancies is rare. We present two cases of splenic rupture which occurred in a man with a secondary high-grade non-Hodgkin's lymphoma and a woman with chronic lymphocytic leukemia (CLL). In a review of the literature, we have been able to identify 136 cases of pathologic splenic rupture since 1861; 34% have occurred in acute leukemias, 34% in non-Hodgkin's lymphomas, and 18% in chronic myelogenous leukemia (CML). We find a male-to-female ratio of 3:1, with considerable differences for the specific diseases encountered. Pathologic rupture of the spleen has happened almost exclusively in adults and the ruptured spleens are generally moderately to severely enlarged. It seems that, apart from splenic infiltration by a hematologic disease, splenic infarcts and coagulation disorders (which have previously been advanced as the most important pathophysiologic factors leading to rupture), male sex, adulthood, severe splenomegaly, and cytoreductive chemotherapy may increase the risk for pathologic splenic rupture. We briefly discuss symptoms preceding the event, diagnostic possibilities, and the outcome with operative and conservative approaches.

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Spontaneous (pathological) rupture of the spleen in non-Hodgkin's lymphoma

Cited by 2 publications

References 16 publications

Occult splenic rupture with cardiovascular collapse: a report of three cases in critically ill patients

Occult splenic rupture with cardiovascular collapse: a report of three cases in critically ill patients

Pathologic rupture of the spleen in hematologic malignancies: two additional cases

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