Spontaneous hypoglycaemia in a patient with Graves' disease

Paudyal, Buddhi; Shakya, Mila; Basnyat, Buddha

doi:10.1136/bcr-2016-214801

Cited by 3 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is essentially a rare autoimmune disorder caused by the spontaneous production of anti-insulin and anti-insulin receptor antibodies which bind insulin/proinsulin and/or insulin receptors and work as insulin-mimetic leading to predominantly postprandial hyperinsulinemic hypoglycemia [9,72]. Graves' disease is frequently present in Hirata syndrome and appears to be particularly prevalent in Japan [73].…”

Section: Insulin Autoimmune Hypoglycemiamentioning

confidence: 99%

Causes of Hypoglycemia

Abu-Odeh¹,

Alnatour²,

Fino³

2022

Basics of Hypoglycemia

View full text Add to dashboard Cite

Blood glucose levels may vary during the day, when this variation goes below a specific limit, hypoglycemia occurs. Hypoglycemia is often associated with reductions in quality of life and even the risk of death. Moreover, hypoglycemia is correlated with physical and/or psychological morbidity. It is usually a result of the complex interaction between hyperinsulinemia and the compromised physiological and behavioral responses attempting to reduce glucose levels. Nevertheless, several conditions can cause hypoglycemia, both in diabetic and non-diabetic patients. Mutually, diabetic and non-diabetic hypoglycemia is common in terms of several medications, alcohol ingestion, critical illnesses, and non-B cell tumors.

show abstract

Section: Insulin Autoimmune Hypoglycemiamentioning

confidence: 99%

Causes of Hypoglycemia

Abu-Odeh¹,

Alnatour²,

Fino³

2022

Basics of Hypoglycemia

View full text Add to dashboard Cite

show abstract

Glycemic variation in uncontrolled Graves’ disease patients with normal glucose metabolism: Assessment by continuous glucose monitoring

et al. 2018

Endocrine

View full text Add to dashboard Cite

Purpose To observe the glycemic variation (GV) in uncontrolled Graves’ disease (GD) patients with normal glucose metabolism measured by continuous glucose monitoring (CGM). Methods This was a single-center, open-label, observational study. From January 2017 to October 2017, 20 GD patients with normal glucose metabolism and 24 healthy control subjects were recruited. Serum samples were obtained at 0, 30, and 120 min after oral glucose loading for glucose, insulin, and C-peptide level measurements. Fasting plasma fasting free triiodothyronine (FT3), free thyroxin (FT4), and thyroid stimulating hormone concentrations were also detected. All participants were subjected to a 3-day CGM after baseline data were collected. The primary endpoint was the difference in the mean amplitude of the glycemic excursions between the two groups. Results Compared with the healthy subjects, the GD patients had higher mean amplitude of glycemic excursions (MAGE) ( P < 0.01). Multiple linear stepwise regression analysis showed that FT4 level was an independent factor for the MAGE. Interestingly, the GD patients had a significant prolongation in the time to peak glucose, especially after breakfast ( P < 0.01), and the elevation in the incremental area under the curve of glucose after breakfast till 4 hours later. Conclusions Uncontrolled GD patients with normal glucose metabolism had a greater GV, and the FT4 level may contributed to the increased GV.

show abstract

Carbimazole

2016

Reactions Weekly

View full text Add to dashboard Cite

Spontaneous hypoglycaemia in a patient with Graves' disease

Cited by 3 publications

References 11 publications

Causes of Hypoglycemia

Causes of Hypoglycemia

Glycemic variation in uncontrolled Graves’ disease patients with normal glucose metabolism: Assessment by continuous glucose monitoring

Carbimazole

Contact Info

Product

Resources

About