Spontaneous Formation of Highly Concentrated Oil-in-Water Emulsions

Ozawa, Kazuyo; Solans, Conxita; Kunieda, H.

doi:10.1006/jcis.1997.4761

Cited by 35 publications

(19 citation statements)

References 16 publications

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“…However, it has been shown that the emulsions are very unstable and coalescence rate is extremely fast (Figure 3). If the temperature of the system is quickly moved away from the PIT by a rapid cooling or heating, kinetically stable o/w or w/o emulsions, respectively, can be produced 23,41,44,45 . During this fast cooling process, the surfactant molecules rapidly migrate from the oil phase into the aqueous phase, resulting in the spontaneous formation of small oil droplets due to the increase in interfacial area and turbulent flow generated 16 .…”

Section: Formation Principlementioning

confidence: 99%

“…In the fast cooling process, the mixture is rapid cooled either by immersing into an ice bath 44,[46][47][48][49] or by diluting with cold water 17,27,34,43,50 . The influences of the formation parameters (i.e., preparation temperature, electrolytes, temperature cycling process and cooling rate) and composition parameters (i.e., oil type and surfactant concentration) have been investigated and reported.…”

Section: Preparation Conditionsmentioning

confidence: 99%

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Preparation of nanoemulsions by phase inversion temperature (PIT)

Jintapattanakit¹

2018

Pharm Sci Asia

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Section: Formation Principlementioning

confidence: 99%

Section: Preparation Conditionsmentioning

confidence: 99%

Preparation of nanoemulsions by phase inversion temperature (PIT)

Jintapattanakit¹

2018

Pharm Sci Asia

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“…Although commonly used in industry for decades, emulsions are still the object of fundamental research activity. Efforts have, in particular, been devoted to understand the role of solid particles in Ramsden–Pickering emulsions − to address stability properties of emulsified dispersions , and to the development of low energy processes for nanoemulsion production. , In this context, intense activity has also been devoted to the description of microemulsions and spontaneous emulsification (SE) mechanisms. − The latter are known to stimulate mass transport phenomena that find applications in a wide range of industrial processes. − …”

Section: Introductionmentioning

confidence: 99%

Spontaneous Microstructure Formation at Water/Paraffin Oil Interfaces

et al. 2017

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An experimental investigation of spontaneous emulsification is proposed with a water drop pendant in a paraffin oil (PO) solution loaded with a surfactant (SPAN80). Optical microscopy in a transmission mode is employed for high-spatial-resolution image recording. The kinetics of spontaneous emulsification is studied. It is shown to generate a darkening of the drops because of interface modification with a characteristic time that depends upon the SPAN80 concentration. For low concentrations, spontaneous emulsification is slow and produces micrometer-sized droplets, whereas for large concentrations, it is fast and bush-like microstructures are observed. These microstructures increase in size and progressively invade the complete water/PO interfaces, detach, and finally migrate into the PO phase. This transport phenomenon withdraws water from the drops and leads to a gradual shrinking of their volume. At the end of this process, they appear as deformed objects surrounded by a loose membrane.

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“…These emulsions can be prepared by a method based on the phase inversion temperature (PIT) (31). Low-energy emulsification methods like PIT, make use of the phase transitions taking place during the emulsification process to produce highly concentrated emulsions almost spontaneously (32)(33)(34). PIT method is based on solubility changes, with temperature, of polyoxyethylene-type nonionic surfactants.…”

Section: Introductionmentioning

confidence: 99%

Drug Delivery Properties of Macroporous Polystyrene Solid Foams

Canal

Aparicio²,

Vílchez³

et al. 2012

J Pharm Pharm Sci

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Purpose. Polymeric porous foams have been evaluated as possible new pharmaceutical dosage forms. Methods. These materials were obtained by polymerization in the continuous phase of highly concentrated emulsions prepared by the phase inversion temperature method. Their porosity, specific surface and surface topography were characterized, and the incorporation and release of active principles was studied using ketoprofen as model lipophilic molecule. Results. Solid foams with very high pore volume, mainly inside macropores, were obtained by this method. The pore morphology of the materials was characterized, and very rough topography was observed, which contributed to their nearly superhydrophobic properties. These solid foams could be used as delivery systems for active principles with pharmaceutical interest, and in the present work ketoprofen was used as a model lipophilic molecule. Conclusions. Drug incorporation and release was studied from solid foam disks, using different concentrations of the loading solutions, achieving a delayed release with short lag-time. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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Spontaneous Formation of Highly Concentrated Oil-in-Water Emulsions

Cited by 35 publications

References 16 publications

Preparation of nanoemulsions by phase inversion temperature (PIT)

Preparation of nanoemulsions by phase inversion temperature (PIT)

Spontaneous Microstructure Formation at Water/Paraffin Oil Interfaces

Drug Delivery Properties of Macroporous Polystyrene Solid Foams

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