Spontaneous fertility and in vitro fertilization outcome: new evidence of human papillomavirus sperm infection

Garolla, Andrea; Engl, Bruno; Pizzol, Damiano; Ghezzi, Michele; Bertoldo, Alessandro; Bottacin, Alberto; Noventa, Marco; Foresta, Carlo

doi:10.1016/j.fertnstert.2015.09.018

Cited by 86 publications

(104 citation statements)

References 27 publications

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“…Indeed, our data indicated that unvaccinated women with a history of STI/PID had appreciably lower fecundability; those vaccinated with a history of STI/PID had similar fecundability to unvaccinated women without a history of STI/PID. These findings agree with the animal literature demonstrating no adverse effects of HPV vaccination on rat fecundability and with the human literature finding adverse effects of HPV infection on fertility …”

Section: Commentsupporting

confidence: 92%

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The Effect of Vaccination Against Human Papillomavirus on Fecundability

McInerney

Hatch

Wesselink

et al. 2017

Paediatric Perinatal Epid

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Background The human papillomavirus (HPV) vaccine was developed to prevent infection with strains of HPV that cause cervical cancer. While HPV infection has been associated with reduced semen quality and lower pregnancy rates in some, no studies have examined the relationship between HPV vaccination and fecundability. We hypothesize that HPV prevention via vaccination will protect fecundity. Methods We analyzed data from Pregnancy Study Online (PRESTO), a preconception cohort of North American pregnancy planners. Between 2013 and 2017, we followed 3,483 female pregnancy planners and 1,022 of their male partners for 12 months or until reported pregnancy, whichever came first. At baseline, participants reported whether they had been vaccinated against HPV and their age at vaccination. We estimated fecundability ratios (FR) and 95% confidence intervals (CI) using proportional probabilities models adjusted for sociodemographics, smoking, and abnormal Pap test before HPV vaccination (females only). Results HPV vaccination was more prevalent among females (33.9%) than males (5.2%). There was little overall association between female vaccination (FR=0.98, 95% CI: 0.90, 1.08) or male vaccination (FR=1.07, 95% CI: 0.79, 1.46) and fecundability. Among females with a history of sexually transmitted infections or pelvic inflammatory disease (i.e., a group at high risk of exposure to HPV infection), those vaccinated against HPV had higher fecundability than those not vaccinated (FR=1.35, 95% CI: 0.99, 1.86). Conclusion Although HPV vaccination had little effect on fecundability overall, HPV vaccination was positively associated with fecundability among women with a history of sexually transmitted infections.

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Section: Commentsupporting

confidence: 92%

“…Detectable HPV infection among males has been associated with reduced sperm motility, increased antisperm antibodies, and lower pregnancy rates in studies of infertile couples; another study found no effect on semen quality . Among females undergoing intrauterine insemination, 1.9% with detectable HPV infection conceived compared with 11.4% without the virus .…”

mentioning

confidence: 97%

The Effect of Vaccination Against Human Papillomavirus on Fecundability

McInerney

Hatch

Wesselink

et al. 2017

Paediatric Perinatal Epid

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“…After the removal of 10 records as duplicates and screening of 92 through their abstracts, 38 studies were identified as possibly eligible for inclusion and retrieved as full texts. Of these, 24 studies were excluded (Table S1), two studies were ongoing 15,16 , two of those eligible were not used in the meta-analysis owing to a lack of data of interest 17,18 and 10 that met the qualitative and quantitative criteria for inclusion in our meta-analysis were selected 6,7,[19][20][21][22][23][24][25][26] (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Effect of human papilloma virus infection onin‐vitrofertilization outcome: systematic review and meta‐analysis

Siristatidis

Vaidakis

Sertedaki

et al. 2018

Ultrasound in Obstet & Gyne

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“…Men producing sperm within the normal Cap-Score range and failing to generate pregnancy within two IUI cycles might be producing sperm that lack the ability to initiate embryo development (Swann, Saunders, Rogers, & Lai, 2006;Yoon et al, 2008). As yet another alternative, recent evidence suggests that although there is little association between the presence of seminal human papillomavirus and semen analysis parameters (Luttmer et al, 2016), men with this infection have reduced ability to generate pregnancy (Garolla et al, 2016). The infected sperm are still able to gain access to oocytes and fertilize (Foresta et al, 2011), but appear to have an early reduction in embryo viability beyond that event.…”

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confidence: 99%

Cap‐Score™ prospectively predicts probability of pregnancy

Schinfeld

Sharara

Morris³

et al. 2018

Molecular Reproduction Devel

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Semen analysis (SA) poorly predicts male fertility, because it does not assess sperm fertilizing ability. The percentage of capacitated sperm determined by GM1 localization (“Cap‐Score™”), differs between cohorts of fertile and potentially infertile men, and retrospectively, between men conceiving or failing to conceive by intrauterine insemination (IUI). Here, we prospectively tested whether Cap‐Score can predict male fertility with the outcome being clinical pregnancy within ≤3 IUI cycles. Cap‐Score and SA were performed (n = 208) with outcomes initially available for 91 men. Men were predicted to have either low (n = 47) or high (n = 44) chance of generating pregnancy using previously‐defined Cap‐Score reference ranges. Absolute and cumulative pregnancy rates were reduced in men predicted to have low pregnancy rates versus high ([absolute: 10.6% vs. 29.5%; p = 0.04]; [cumulative: 4.3% vs. 18.2%, 9.9% vs. 29.1%, and 14.0% vs. 32.8% for cycles 1–3; n = 91, 64, and 41; p = 0.02]). Only Cap‐Score, not male/female age or SA results, differed significantly between outcome groups. Logistic regression evaluated Cap‐Score and SA results relative to the probability of generating pregnancy (PGP) for men who were successful in, or completed, three IUI cycles (n = 57). Cap‐Score was significantly related to PGP (p = 0.01). The model fit was then tested with 67 additional patients (n = 124; five clinics); the equation changed minimally, but fit improved (p < 0.001; margin of error: 4%). The Akaike Information Criterion found the best model used Cap‐Score as the only predictor. These data show that Cap‐Score provides a practical, predictive assessment of male fertility, with applications in assisted reproduction and treatment of male infertility.

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Spontaneous fertility and in vitro fertilization outcome: new evidence of human papillomavirus sperm infection

Cited by 86 publications

References 27 publications

The Effect of Vaccination Against Human Papillomavirus on Fecundability

The Effect of Vaccination Against Human Papillomavirus on Fecundability

Effect of human papilloma virus infection onin‐vitrofertilization outcome: systematic review and meta‐analysis

Cap‐Score™ prospectively predicts probability of pregnancy

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