Effect of human papilloma virus infection on<i>in‐vitro</i>fertilization outcome: systematic review and meta‐analysis

Siristatidis, Charalambos; Vaidakis, Dennis; Sertedaki, Eleni; Martins, Wellington P.

doi:10.1002/uog.17550

Cited by 21 publications

(25 citation statements)

References 39 publications

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“…Including all the relative publications concerning HPV and ART outcome, it was found that there is no enough evidence to draw solid conclusions regarding the impact of HPV infection in women on assisted reproductive outcomes. Further to the above founding, it was also reported that when HPV infection is present in the male partner, it appears that there is a negative effect on live birth/ongoing pregnancy rate and an increase in the miscarriage rate [ 51 ]. Lastly, following the previous novel meta-analysis, Xiong and colleagues [ 52 ], performed another meta-analysis relating the HPV risk with spontaneous abortion and spontaneous preterm birth (sPTB).…”

Section: Hpv and Assisted Reproductive Technology (Art)mentioning

confidence: 87%

“…A recent novel meta-analysis performed by Siristatidis and colleagues [ 51 ] is the first one that complexes the HPV infection and ART outcome. Including all the relative publications concerning HPV and ART outcome, it was found that there is no enough evidence to draw solid conclusions regarding the impact of HPV infection in women on assisted reproductive outcomes.…”

Section: Hpv and Assisted Reproductive Technology (Art)mentioning

confidence: 99%

See 1 more Smart Citation

Human Papilloma Virus (HPV) and Fertilization: A Mini Review

et al. 2018

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Human papilloma virus (HPV) is one of the most prevalent viral sexually transmitted diseases. The ability of HPV to induce malignancy in the anogenital tract and stomato-pharyngeal cavity is well documented. Moreover, HPV infection may also affect reproductive health and fertility. Although, the impact of HPV on female fertility has not been thoroughly studied it has been found also to have an impact on semen parameters. Relative information can be obtained from studies investigating the relationship between HPV and pregnancy success. Furthermore, there is an ongoing debate whether HPV alters the efficacy of assisted reproductive technologies. An association between HPV and assisted reproductive technologies (ART) programs has been reported. Nevertheless, due to conflicting data and the small number of existing studies further research is required. It remains to be clarified whether HPV detection and genotyping could be included in the diagnostic procedures in couples undergoing in vitro fertilization (IVF)/intrauterine insemination (IUI) treatments. Vaccination of both genders against HPV can reduce the prevalence of HPV infection and eliminate its implications on human fertility. The aim of the present mini-review is to reiterate the association between HPV and human fertility through a systematic literature review.

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Section: Hpv and Assisted Reproductive Technology (Art)mentioning

confidence: 87%

Section: Hpv and Assisted Reproductive Technology (Art)mentioning

confidence: 99%

Human Papilloma Virus (HPV) and Fertilization: A Mini Review

et al. 2018

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“…Although previous meta-analyses have established an association between HPV infection and both male infertility (Lyu et al, 2017) and the outcomes of natural or IVF/ICSI pregnancies (Siristatidis et al, 2018;Xiong et al, 2018), little is known regarding its role in female infertility. This is thought to be the first meta-analysis of studies comparing the prevalence of HPV infection in the infertile and general female population.…”

Section: Discussionmentioning

confidence: 99%

“…Xiong et al (2018) found that infection with the indiscriminate HPV genotype increased the risk of spontaneous abortion, and HR-HPV infection was a risk factor for spontaneous preterm birth. However, there is not enough evidence to indicate an association between HPV infections and the pregnancy or spontaneous abortion rates of ART (Siristatidis et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection and female infertility: a systematic review and meta-analysis

Yuan

Qiu

et al. 2020

Reproductive BioMedicine Online

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“…Though studies have established an association between HPV infection and both male infertility [24][25][26][27] and assisted reproductive technology (ART) outcomes [28][29][30], the mechanism by which HPV infection decreases female fertility remains unclear. However, Yuan et al performed a meta-analysis on HPV infection and female infertility which showed a significant association between HR-HPV and female infertility (odds ratio 2.33, 95% CI 1.42-3.83, p = 0.0008) but surmised that HR-HPV is more likely a trigger factor rather than an independent cause [31].…”

Section: Discussionmentioning

confidence: 99%

Female Human Papillomavirus Infection Associated with Increased Risk of Infertility: A Nationwide Population-Based Cohort Study

Hsu

Tsui

Wei

et al. 2020

IJERPH

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Objective. This study investigated whether women with a history of human papillomavirus (HPV) infection have an increased risk of infertility. Material and Methods. All patients with an HPV infection (n = 11,198) in Taiwan’s National Health Insurance Research Database (2000–2012) were propensity score matched with control subjects (n = 11,198) without an HPV infection by age, sex, index year, and relevant co-morbidities. Both groups were tracked until a diagnosis of infertility was recorded. The Chi-square test was used to analyze the distribution of demographic characteristics in the HPV group and non-HPV group. A Cox proportional hazards regression was used to estimate the hazard ratios (HRs) for the development of infertility, adjusting for age, sex, and co-morbidities. The Kaplan–Meier method was used to plot the cumulative incidence curves. We also performed negative controls to test for possible unmeasured confounding. Results. The HPV cohort had a higher risk of infertility. The adjusted HR (aHR) was found to be 1.39 (95% CI = 1.19–1.63) after adjusting for demographic characteristics and relevant co-morbidities. In the age subgroup analysis, patients with an HPV infection had an increased risk of infertility compared to the non-HPV cohort in the group aged 26 to 35 years (aHR, 1.53; 95% CI = 1.24–1.88). As we used propensity score matching to treat measurable confounders and negative controls to access unmeasured confounders, the findings of the study are robust. Conclusions. Among females of reproductive age, HPV infection is a potential risk factor that predisposes individuals to subsequent infertility.

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Effect of human papilloma virus infection onin‐vitrofertilization outcome: systematic review and meta‐analysis

Cited by 21 publications

References 39 publications

Human Papilloma Virus (HPV) and Fertilization: A Mini Review

Human Papilloma Virus (HPV) and Fertilization: A Mini Review

Human papillomavirus infection and female infertility: a systematic review and meta-analysis

Female Human Papillomavirus Infection Associated with Increased Risk of Infertility: A Nationwide Population-Based Cohort Study

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