Spontaneous familial systemic lupus erythematosus in a canine breeding colony

Hubert, B.; Teichner, M.; Fournel, C.; Monier, J. C.

doi:10.1016/0021-9975(88)90032-1

Cited by 17 publications

(5 citation statements)

References 10 publications

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“…In humans with GDLE, women are affected more often than men (female‐to‐male ratio of 1.5) . Interestingly, and surprisingly, German shepherd dogs, a breed predisposed to develop several forms of LE, such as SLE, localized facial DLE and MCLE, were not represented in this population. This discrepancy may be explained by the German shepherd dog breed not being predisposed to GDLE, by the small size of our study group or by a possible clinical misdiagnosis of this disease as “idiopathic lichenoid dermatoses” based on histopathological identification of a “lichenoid tissue reaction” in dogs .…”

Section: Discussionmentioning

confidence: 88%

Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases)

Banović

Linder

Uri

et al. 2016

Veterinary Dermatology

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Background -Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized.Hypothesis/Objectives -We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE.Methods -Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis). Direct immunofluorescence (IF) and antinuclear antibody serology were investigated whenever possible.Results -Various breeds were affected in their mid-to late adulthood. Selection criteria of generalized multifocal, annular ("discoid") to polycyclic plaques with pigment changes, erythematous margin, adherent scaling, follicular plugging and central alopecia were shown in all dogs. In nine dogs, plaques contained mild to moderate central scarring with depigmentation and/or hyperpigmentation. There were no dogs in which the disease progressed to systemic lupus erythematosus within a median follow-up of 2.5 years. Per inclusion criteria, interface dermatitis occurred with basement membrane zone (BMZ) thickening, suprabasal apoptosis and/or dermal fibrosis in some dogs. Infundibular interface folliculitis was common; it sometimes transitioned to mural folliculitis in lower follicle segments, and occurred with follicular and sebaceous gland atrophy. The direct IF revealed patchy deposition of immunoglobulin IgG and IgM at the BMZ. Lesions responded to a variety of treatments, including ciclosporin, hydroxychloroquine, topical tacrolimus and tetracycline/niacinamide. Relapses were common after medications were tapered.Conclusions and clinical importance -These observations support the existence of a canine homologue of human GDLE.

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Section: Discussionmentioning

confidence: 88%

Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases)

Banović

Linder

Uri

et al. 2016

Veterinary Dermatology

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“…Such a predisposition is also likely for humans with CLE, because there is increasing evidence of the association of CLE with several risk‐associated genes . Interestingly, German shepherd dogs are already known to be predisposed to develop other forms of LE, such as SLE or classic DLE . Our observations further support this breed being uniquely predisposed to develop LE variants that could occur with or without skin or mucosal lesions.…”

Section: Discussionmentioning

confidence: 99%

Mucocutaneous lupus erythematosus in dogs (21 cases)

Olivry

Rossi²,

Banović

et al. 2015

Veterinary Dermatology

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“…Seronegative SLE cases are described in the veterinary literature, 15,19–21 although it is important to note less stringent diagnostic criteria were applied when compared to human guidelines. In one case series, fulfilment of ACR criteria despite a low ANA titre was considered sufficient evidence for a diagnosis of SLE, with the suggestion that a positive titre may not develop until SLE is more advanced 13 . With 5% of cases in people and 17–54% cases in dogs reported with seronegative SLE 15,19–21 it was considered plausible to suggest that, due to the significant classification criteria fulfilled, this patient may have had SLE.…”

Section: Discussionmentioning

confidence: 99%

“…In one case series, fulfilment of ACR criteria despite a low ANA titre was considered sufficient evidence for a diagnosis of SLE, with the suggestion that a positive titre may not develop until SLE is more advanced. 13 With 5% of cases in people and 17-54% cases in dogs reported with seronegative SLE 15,[19][20][21] it was considered plausible to suggest that, due to the significant classification criteria fulfilled, this patient may have had SLE. Adjunctive immunological criteria in humans with SLE include antiphospholipid antibodies and low complement levels.…”

Section: Discussionmentioning

confidence: 99%

“…Trigger factors include ultraviolet light, sex hormones, medications and infectious disease 12 . There is evidence of genetic influence in dogs 13 and both age and breed predispositions have been documented 3,4 . No infectious causes have yet been identified in dogs but an infection could be assumed to trigger a polysystemic autoimmune reaction 14 .…”

Section: Discussionmentioning

confidence: 99%

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Polysystemic autoimmune disease in a Cocker Spaniel with neurological and cardiac manifestations

Bütler¹,

Hall²,

McCallum³

2021

Vet Record Case Reports

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A 6‐year‐old female‐neutered Cocker Spaniel was presented for investigation of a 3‐week history of persistent pyrexia, lethargy, thoracic spinal pain and anorexia. Bloodwork documented marked elevation in C‐reactive protein (CRP) 103.5 mg/L (0‐8.2 mg/L) and haematological changes consistent with marked systemic inflammation. Investigations confirmed non‐erosive immune‐mediated polyarthritis, sterile neutrophilic pericarditis, non‐degenerate neutrophilic inflammation within the cerebrospinal fluid (CSF) consistent with neutrophilic pleocytosis, a small volume pleural effusion, elevated cardiac troponin and proteinuria. Systemic lupus erythematous (SLE) was considered despite a borderline anti‐nuclear antibody titre (1:40). Following initiation of immunosuppressive therapy (2 mg/kg prednisolone q 24 hrs), the patient had rapid resolution of clinical signs with normalisation of proteinuria, CRP and pericardial effusion after 1 month of treatment. This case represents an interesting presentation of polysystemic autoimmune disease in the dog.

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Spontaneous familial systemic lupus erythematosus in a canine breeding colony

Cited by 17 publications

References 10 publications

Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases)

Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases)

Mucocutaneous lupus erythematosus in dogs (21 cases)

Polysystemic autoimmune disease in a Cocker Spaniel with neurological and cardiac manifestations

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