Spontaneous Emulsification of Oils Containing Hydrocarbon, Nonionic Surfactant, and Oleyl Alcohol

Rang, Moon-Jeong; Miller, Clarence A.

doi:10.1006/jcis.1998.5865

Cited by 115 publications

(69 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For self-emulsifying system, when the oil phase is introduced into the aqueous phase with gentle agitation, the aqueous phase will penetrate through the interface into oil phase until the interface of the two phases is disrupted. Consequently, oil droplets are formed resulting in emulsification (Rang & Miller, 1999). The emulsification time of formulations containing Tween 80 was found to be less than 1 min while for Cremophor EL it lies between 1-2 min.…”

Section: Time For Self-nanoemulsificationmentioning

confidence: 95%

Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization,in vitroandin vivoevaluation

et al. 2014

View full text Add to dashboard Cite

(2015) Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization, invitro and invivo evaluation, Drug Delivery, 22:4, 552-561, DOI: 10.3109/10717544.2013 Abstract Naringenin (NRG), predominant flavanone in grapefruits, possesses anti-inflammatory, anti-carcinogenic, hepato-protective and anti-lipid peroxidation effects. Slow dissolution after oral ingestion due to its poor solubility in water, as well as low bioavailability following oral administration, restricts its therapeutic application. The study is an attempt to improve the solubility and bioavailability of NRG by employing self-nanoemulsifying drug delivery technique. Preliminary screening was carried out to select oil, surfactant and co-surfactant, based on solubilization and emulsification efficiency of the components. Pseudo ternary phase diagrams were constructed to identify the area of nanoemulsification. The developed selfnanoemulsifying drug delivery systems (SNEDDS) were evaluated in term of goluble size, globule size distribution, zeta potential, and surface morphology of nanoemulsions so obtained. The TEM analysis proves that nanoemulsion shows a droplet size less than 50 nm. Freeze thaw cycling and centrifugation studies were carried out to confirm the stability of the developed SNEDDS. In vitro drug release from SNEDDS was significantly higher (p50.005) than pure drug. Furthermore, area under the drug concentration time-curve (AUC 0-24 ) of NRG from SNEDDS formulation revealed a significant increase (p50.005) in NRG absorption compared to NRG alone. The increase in drug release and bioavailability as compared to drug suspension from SNEDDS formulation may be attributed to the nanosized droplets and enhanced solubility of NRG in the SNEDDS.

show abstract

Section: Time For Self-nanoemulsificationmentioning

confidence: 95%

Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization,in vitroandin vivoevaluation

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Studies showed that nanoemulsions with very small droplet sizes can be obtained through low-energy methods if, during the emulsification process, the oil is completely dissolved in a single phase, like a bicontinuous microemulsion or a lamellar crystalline phase (Mohlin et al, 2003;Rang & Miller, 1999).The further evolution of the system led to the dislocation of this continuous phase into small nanodroplets. For instance, in the EIP method, the addition of water to a system of water/oil/surfactant forming a lamellar phase increases the hydratation degree of the surfactant polar head thereby increasing its spontaneous curvature.…”

Section: Nanoparticles By Emulsion Inversion Point (Eip) Methodsmentioning

confidence: 99%

Low Energy Emulsification Methods for Nanoparticles Synthesis

Sadtler¹,

Galindo-Alvarez²,

Bégué³

2012

The Delivery of Nanoparticles

View full text Add to dashboard Cite

“…14 The ease of emulsification has been suggested to be related to the ease of water penetration into various liquid crystals or gel phases formed on the surface of the droplet. 15,16 The interface between the oil and aqueous continuous phases is formed upon addition of a binary mixture (oil/non-ionic surfactant) to water. 15 This is followed by solubilization within the oil phase, as a result of aqueous penetration through the interface.…”

Section: …………Eqmentioning

confidence: 99%

Self-Emulsifying Drug Delivery Systems: A Review

Reza

2013

Int. J. Pharma Life Sci.

View full text Add to dashboard Cite

Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble or lipophilic drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro-or nanoemulsions containing the solubilized drug. Owing to its miniscule globule size, the micro/nanoemulsified drug can easily be absorbed through lymphatic pathways, bypassing the hepatic first-pass effect. But it has drawbacks as formulation development, quality control, stability etc. These liquid SEDDS can be converted into solid dosage form without affecting drug release property. After administering the drug gets released and self emulsify in the GI tract. Generally solid SEDDS are formed with mono, di or triglycrides of fatty acid, non ionic surfactants and solidifying agents with diluents such as microcrystalline cellulose, lactose etc.

show abstract

Spontaneous Emulsification of Oils Containing Hydrocarbon, Nonionic Surfactant, and Oleyl Alcohol

Cited by 115 publications

References 13 publications

Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization,in vitroandin vivoevaluation

Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization,in vitroandin vivoevaluation

Low Energy Emulsification Methods for Nanoparticles Synthesis

Self-Emulsifying Drug Delivery Systems: A Review

Contact Info

Product

Resources

About