Self-Emulsifying Drug Delivery Systems: A Review

Reza, Jamilur

doi:10.3329/ijpls.v2i2.15453

Cited by 4 publications

(1 citation statement)

References 16 publications

(7 reference statements)

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“…The methods to accomplish this depend on the chemical nature of the drug and the type of drug product under consideration. Various techniques are reported to improve the dissolution of poorly soluble drugs, including solid dispersions [ 6 ], crystal engineering [ 7 ], ball milling [ 8 ], complexation [ 9 ], self-emulsifying drug delivery systems [ 10 ], and the use of mesoporous silica carriers [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique

Elkhodairy

El-Saghir

Al-Subayiel

2014

BioMed Research International

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The present study aimed at the formulation of matrix tablets for colon-specific drug delivery (CSDD) system of indomethacin (IDM) by applying liquisolid (LS) technique. A CSDD system based on time-dependent polymethacrylates and enzyme degradable polysaccharides was established. Eudragit RL 100 (E-RL 100) was employed as time-dependent polymer, whereas bacterial degradable polysaccharides were presented as LS systems loaded with the drug. Indomethacin-loaded LS systems were prepared using different polysaccharides, namely, guar gum (GG), pectin (PEC), and chitosan (CH), as carriers separately or in mixtures of different ratios of 1 : 3, 1 : 1, and 3 : 1. Liquisolid systems that displayed promising results concerning drug release rate in both pH 1.2 and pH 6.8 were compressed into tablets after the addition of the calculated amount of E-RL 100 and lubrication with magnesium stearate and talc in the ratio of 1 : 9. It was found that E-RL 100 improved the flowability and compressibility of all LS formulations. The release data revealed that all formulations succeeded to sustain drug release over a period of 24 hours. Stability study indicated that PEC-based LS system as well as its matrix tablets was stable over the period of storage (one year) and could provide a minimum shelf life of two years.

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Section: Introductionmentioning

confidence: 99%

Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique

Elkhodairy

El-Saghir

Al-Subayiel

2014

BioMed Research International

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Polymers as Drug Delivery Systems

Sabaa

2016

Biodegradable and Biobased Polymers for Environmental and Biomedical Applications

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Study of the Composition of Biologically Active Forms of Sea Buckthorn (Hippophae Rhamnoides L.) Leaves by Gc-MS

Trineeva,

Kovaleva

2023

JCPRM

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Hippophae rhamnoides L. is a perennial shrub of the Elaegnaceae family, which has a significant distribution area (both in cultivation and in the wild) and an annually renewable raw material base (fruits and leaves). The leaves of sea buckthorn are characterized by a high accumulation of various groups of biologically active substances. However, the fraction of lipophilic biologically active substances of this type of medicinal plant material remains poorly understood in terms of composition and pharmacological properties. The aim of the work was to study the phytochemical composition of the lipophilic fractions of sea buckthorn leaves by GC/MS with a predictive in silico assessment of promising types of pharmacological activity of the identified compounds for the subsequent targeted development of medicinal herbal preparations based on this medicinal plant material with a certain spectrum of action. The object of the study was the leaves of three phenological phases of plant life collected in the territory of the Voronezh region and dried by the air-shadow method to a residual moisture content of not more than 10% in 2022. On the chromatograms in the leaves harvested in different phenophases of development, the presence of peaks of about 40 compounds is observed – 20 each in the preparations removed from the leaves of phases I and III; 16 – phases II of blanks, of which 14 compounds were identified – 7, 8, and 10 in phenophases I, II, and III, respectively.The greatest number of compounds of the group of sugars, sterols, aliphatic and alicyclic alcohols was typical for the leaves of the phenological phase III – the phase of technical maturity of the fruit, which is due to the accumulation of these biologically active substances in the process of life. However, leaves already in the first phase of harvesting can be considered as a potential source of vitamins and sterols due to their significant accumulation. The results of the in silico study position phytosterols (betulin and γ-sitosterol) as the target group of biologically active substances in the lipophilic fraction of the leaves of the third phase of the harvest due to the large accumulation and the presence of a high probability of hypolipidemic, hypocholesterolemic and hepatoprotective activities. At the same time, the maximum accumulation of this fraction in the leaves during the harvesting period of fruits, the main pharmacopoeial valuable raw material of this plant, contributes to the possibility of waste-free rational use of plant resources.

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Self-Emulsifying Drug Delivery Systems: A Review

Cited by 4 publications

References 16 publications

Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique

Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique

Polymers as Drug Delivery Systems

Study of the Composition of Biologically Active Forms of Sea Buckthorn (Hippophae Rhamnoides L.) Leaves by Gc-MS

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