Spontaneous dermal abscesses and ulcers as a result of Serratia marcescens

Friedman, N Deborah; Peterson, Neeraja B; Sumner, William T.; Alexander, Barbara D.

doi:10.1067/mjd.2003.312

Cited by 20 publications

(14 citation statements)

References 5 publications

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“…6 In our case there was a rapid evolution from nodules to excavated ulcers, through spontaneous drainage of hematic content. In two recent reports, 7,9 Serratia was the cause of painful nodules with abscess formation in the leg, a clinical presentation with similarities to our case, but without the intensity of the clinical picture that occurred in our patient. In one of these reports 9 the patient had, as in our case, alcohol-induced chronic hepatic disease and venous dermatitis, which are known factors associated with complications in infectious cellulites.…”

Section: Recurrent Serratia Marcescens Cutaneous Infection Manifestinsupporting

confidence: 69%

“…3 S marcescens seems to be a rare cause of skin infections, with only a few reports in the literature, typically occurring in elderly or immunocompromised patients. [4][5][6][7][8][9][10] Clinical presentations include chronic cutaneous granulomatous lesions, 4 cellulitis, 5 necrotizing fasciitis, 10 secondary infection of leg ulcers, 5 hidradenitis, 8 and disseminated papular erosions. 6 In our case there was a rapid evolution from nodules to excavated ulcers, through spontaneous drainage of hematic content.…”

Section: Recurrent Serratia Marcescens Cutaneous Infection Manifestinmentioning

confidence: 99%

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Recurrent Serratia marcescens cutaneous infection manifesting as painful nodules and ulcers

João

Serrano

Cachão

et al. 2008

Journal of the American Academy of Dermatology

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Section: Recurrent Serratia Marcescens Cutaneous Infection Manifestinsupporting

confidence: 69%

Section: Recurrent Serratia Marcescens Cutaneous Infection Manifestinmentioning

confidence: 99%

Recurrent Serratia marcescens cutaneous infection manifesting as painful nodules and ulcers

João

Serrano

Cachão

et al. 2008

Journal of the American Academy of Dermatology

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“…2,[7][8][9] Because of its well-known intrinsic resistance to many antimicrobial agents and the reported outbreaks of extremely resistant strains, such as extended-spectrum b-lactamase-producing and imipenem-resistant strains, S. marcescens has received considerable attention in various clinical settings. [14][15][16][17][18][19] Most cases occur in elderly or immunocompromised patients, producing clinically significant infections. [14][15][16][17][18][19] Most cases occur in elderly or immunocompromised patients, producing clinically significant infections.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Serratia marcescens infections in Korea: A retrospective analysis of 13 patients

Seo

Shin

et al. 2015

The Journal of Dermatology

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Serratia marcescens is a Gram-negative bacillus belonging to the Enterobacteriaceae family. Because of increasing reports of antimicrobial resistance, this bacterium has received considerable attention and has emerged as an important pathogen. In order to reveal clinical and microbiological characteristics of S. marcescens cutaneous infection and to suggest appropriate antibiotic treatment, we retrospectively analyzed 17 strains isolated from wound swabs of Korean patients between November 2005 and March 2014. A total of 13 patients (five men and eight women) were included in our study, with a mean age of 46.3 years (range, 21-82). Based on medical history, seven patients were classified as immunocompromised. Prior predisposing factors for infections were noted in 12 patients, including pre-existing leg ulcers or dermatitis (5/13), preceding cancer surgeries (2/13), plastic surgeries and filler injection (2/13), traumas (2/13) and medical procedures following cutaneous abscess (1/13). Cutaneous infections showed various clinical presentations, including spontaneous dermal abscess, fingernail change, painful nodules and papular erosions. We found that third- and fourth-generation cephalosporins, gentamicin, levofloxacin and meropenem appeared active against all 17 strains in vitro. Clinically, all patients treated with empirical first-generation cephalosporin showed treatment resistance, and oral quinolone monotherapy was the most preferred antibiotic regimen without treatment failure, with an average treatment duration of 25 days (range, 14-42). This study demonstrates the various clinical presentations and treatment responses for cutaneous S. marcescens infection. Moreover, we suggest that initial antibiotic coverage should be broad enough to account for multidrug resistance in this rare pathogen.

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“…S. marcescens is rarely involved in soft tissue infections. Indeed, this agent has been found only in a few cases of dermal abscesses and ulcers and cellulitis, and has been encountered in association with other pathogens 5,6 . Necrotizing fasciitis due to S. marcescens exclusively has been only reported in four cases including ours, summarized in Table 1 7–9 .…”

Section: Necrotizing Fasciitis Due To Serratia Marcescensmentioning

confidence: 72%