Spontaneous Cutaneous Papillomatosis in Yaks and Detection and Quantification of Bovine Papillomavirus-1 and -2

Bam, Joken; Kumar, Pawan; Leishangthem, Geeta Devi; Saikia, Anjan; Somvanshi, R.

doi:10.1111/j.1865-1682.2012.01361.x

Cited by 17 publications

(19 citation statements)

References 17 publications

(26 reference statements)

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“…Two samples were found to have mixed infection of BPV-1 and -10. The detection of BPV-10 using PCR in the teat warts of Indian cattle is a novel finding as earlier studies detected only BPV-1 and -2 in the cutaneous warts of cattle (Pangty et al 2010;Kumar et al 2013a), buffalo Kumar et al 2013a) and yak (Bam et al 2012). The association of BPV-10 with the teat warts of cattle was also observed in cattle papillomatosis studies of other countries (Hatama et al 2008).…”

Section: Discussionmentioning

confidence: 56%

Co-infection of bovine papillomavirus type-1 and -10 in teat warts of dairy cattle

Kumar¹,

Jangir²,

Saikumar³

et al. 2013

Vet. Med. - Czech

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The present study was carried out to investigate the involvement of different bovine papillomaviruses in the teat warts of cattle. A total of 11 teat wart samples showing rice grain-like and small, sessile elevated greyish or flesh-like growths were collected from dairy cattle. DNA was extracted from these teat wart samples and PCR and real time PCR techniques were applied using specific primers for BPV-1 and -10 to detect the presence of viral nucleic acid. PCR revealed the presence of viral DNA of BPV-1 and -10 in three and seven samples, respectively. Quantification using real time PCR revealed that the copy numbers of the viral DNA of BPV-1 and -10 DNA varied from 1.12E + 04 to 2.99E + 04 and 3.56E + 02 to 5.23E + 06, respectively. From the present study it can be concluded that BPV-1 and -10 are involved in production of rice grain-like and sessile elevated growths on the teats of cattle.

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Section: Discussionmentioning

confidence: 56%

Co-infection of bovine papillomavirus type-1 and -10 in teat warts of dairy cattle

Kumar¹,

Jangir²,

Saikumar³

et al. 2013

Vet. Med. - Czech

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“…These are classified into three different genera such as Xi PVs, which include pure epitheliotropic BPV‐3, ‐4, ‐6, ‐9, ‐10, ‐11 & ‐12; Delta PVs, which include BPV‐1 and ‐2 that are associated with fibropapillomas; and Epsilon papillomavirus comprising BPV‐5, ‐7 & ‐8, whose genome seems to share similarities with the preceding Xi and Delta PVs (De Villiers et al., ; Ogawa et al., ; Tomita et al., ; Hatama et al., , ; Zhu et al., ). In our Indian studies, BPV‐1 and ‐2 were detected in the cutaneous warts in cattle (Leishangthem et al., ; Singh et al., ; Pangty et al., ), buffaloes (Pangty et al., ; Singh and Somvanshi, ; Nagarajan, ) and yak (Bam et al., ). Bovine papillomaviruse‐2 DNA was also demonstrated/quantified in urine and urinary bladder tumours of EBH‐affected hill cattle (Leishangthem et al., ; Pathania et al., ).…”

Section: Introductionmentioning

confidence: 81%

Detection of Bovine Papilloma Viruses in Wart-Like Lesions of Upper Gastrointestinal Tract of Cattle and Buffaloes

Kumar

Nagarajan

Saikumar

et al. 2013

Transbound Emerg Dis

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In present investigation, etiopathological characterization of upper gastrointestinal tract (GIT) tumours of cattle and buffaloes was undertaken. A total of 27 GIT wart-like lesions in rumen, reticulum, mouth and oesophagus of cattle and buffaloes revealed the presence of small nodular to larger spherical or slender growths with thin base present on mucosa and ruminal pillar. Histopathologically, these cases were diagnosed as fibropapilloma/papilloma. This is the first world record on ruminal papillomatosis in buffaloes. Ruminal warts of cattle and buffaloes revealed the presence of BPV-5, -1 & -2, which is the first report of presence of these BPVs in the ruminal warts from India. Quantitative real-time PCR revealed that DNA samples of different GIT wart-like lesions contained varying amount of BPV DNA copy numbers. Immunohistochemistry revealed that the PCNA and Ki67 immunopositivity was present in the basal and spinosum layer of the fibropapilloma/papilloma, indicating these as the cellular proliferation site. In conclusion, the present investigation revealed that BPV-5, -1 & -2 are associated with certain ruminal wart-like lesions/growths in cattle and buffaloes, and the basal and spinosum layer of the ruminal fibropapilloma/papilloma were cellular proliferation sites.

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“…The majority of the strains clustered within the Deltapapillomavirus genus that encompasses the BPV types considered to be etiological agents of papillomatosis in cattle [12,13,17,18], sarcoid disease in horses [4,5,26], as well as urinary bladder in cow [27]. BPVs 1 and 2 are the most common BPV types distributed worldwide and unusually, they have the ability to infect not only bovines but also other species such as equines [4,5,26], yaks [28], and buffalos [27,29]. In Brazil, these BPV types were already described in studies carried out in cattle herds from the Southern, South-East and North-East regions [13,18,30,31], and the present findings reveals that they are also present in the Amazon region of Brazil.…”

Section: Discussionmentioning

confidence: 99%

Genetic characterization of Amazonian bovine papillomavirus reveals the existence of four new putative types

et al. 2015

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Papillomaviruses are small and complex viruses that belong to the Papillomaviridae family, which comprises 39 genera. The bovine papillomavirus (BPV) causes an infectious disease that is characterized by chronic and proliferative benign tumors that affect cattle worldwide. Different genotypes of BPVs can cause distinct skin and mucosal lesions and the immunity they raise has low cross-protection. This report aimed to genotype BPVs in cattle from Northern Brazil based on nucleotide partial sequences of the L1 ORF. Skin wart samples from 39 bovines clinically and histopathologically diagnosed as cutaneous papillomatosis from Acre and Rondônia States were analyzed. The results revealed four already reported BPV types (BPVs 1, 2, 11, and 13), nine putative new BPV subtypes and four putative new BPV types as well as two putative new BPV types that were already reported. To our knowledge, this is the first record of BPVs from the Brazilian Amazon region that identified new possible BPV types and subtypes circulating in this population. These findings point to the great genetic diversity of BPVs that are present in this region and highlight the importance of this knowledge before further studies about vaccination are attempted.

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Spontaneous Cutaneous Papillomatosis in Yaks and Detection and Quantification of Bovine Papillomavirus-1 and -2

Cited by 17 publications

References 17 publications

Co-infection of bovine papillomavirus type-1 and -10 in teat warts of dairy cattle

Co-infection of bovine papillomavirus type-1 and -10 in teat warts of dairy cattle

Detection of Bovine Papilloma Viruses in Wart-Like Lesions of Upper Gastrointestinal Tract of Cattle and Buffaloes

Genetic characterization of Amazonian bovine papillomavirus reveals the existence of four new putative types

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