Spontaneous complete regression of multiple Bowen's disease in the web‐spaces of the feet

Treatment of Squamous Cell Carcinoma In Situ: A Review

“…Topical treatments other than imiquimod or 5FU include bleomycin in combination with cryotherapy in a patient with human papillomavirus 16–induced SCCIS; 114 tazarotene; 115 diclofenac; 116,117 and a combination of tazarotene, imiquimod, and 5FU 118 . Finally, although leaving SCCIS untreated is generally not recommended, rare instances of spontaneous regression have been noted 119,120 …”

“…118 Finally, although leaving SCCIS untreated is generally not recommended, rare instances of spontaneous regression have been noted. 119,120…”

Interdigital Bowen’s Disease: An Unusual Localization and Literature Review

“…In their case spontaneous complete regression was achieved. They stated that HPV-infected keratinocytes undergo Fas-induced apoptosis in the event of spontaneous regression of HPVrelated Bowen's disease [5]. Wong et al reported four patients with BD on the digits, two patients had on the fingers and two on the toes, treated with photodynamic therapy and suggested that photodynamic therapy is an effective and noninvasive method to treat digital BD [6].…”

Clinical Manifestations of the Human Papillomavirus

“…This complication should be suspected when a rapidly growing tumor is present in a previous scaly lesion. Complete or partial regression has been described in Bowen´s disease [37] but this is not a common phenomenon. Some authors proposed that Bowen´s disease was considered a marker of an internal malignancy; however a later meta-analysis showed that this association was inconsistent [38].…”